| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Marley & Me | $171,175 | -27.5% | 65 | +1 | $2,633 | $485,845 | 2 | NuMetro Distribution | false | false |
| 2 | - | Race to Witch Mountain | $109,144 | - | 55 | - | $1,984 | $109,144 | 1 | Ster-Kinekor Pictures | true | false |
| 3 | 3 | Confessions of a Shopaholic | $66,143 | +0.8% | 51 | - | $1,296 | $302,285 | 3 | Ster-Kinekor Pictures | false | false |
| 4 | 2 | Slumdog Millionaire | $61,787 | -28.7% | 20 | - | $3,089 | $559,925 | 4 | Ster-Kinekor Pictures | false | false |
| 5 | - | Underworld: Rise of the Lycans | $55,130 | - | 35 | - | $1,575 | $55,130 | 1 | Ster-Kinekor Pictures | true | false |
| 6 | - | Gran Torino | $43,830 | - | 40 | - | $1,095 | $43,830 | 1 | NuMetro Distribution | true | false |
| 7 | 4 | The Pink Panther 2 | $37,329 | -25.8% | 62 | -7 | $602 | $513,625 | 5 | Ster-Kinekor Pictures | false | false |
| 8 | 5 | The Curious Case of Benjamin Button | $32,139 | -25.3% | 54 | +11 | $595 | $503,297 | 5 | NuMetro Distribution | false | false |
| 9 | 7 | He's Just Not That Into You | $31,218 | -8.6% | 47 | -3 | $664 | $734,836 | 7 | NuMetro Distribution | false | false |
| 10 | - | The Reader | $29,104 | - | 10 | - | $2,910 | $29,104 | 1 | Ster-Kinekor Pictures | true | false |
| 11 | 6 | Watchmen | $22,720 | -44.3% | 40 | -19 | $568 | $340,144 | 4 | Ster-Kinekor Pictures | false | false |
| 12 | 9 | Bedtime Stories | $19,162 | -11.9% | 34 | -1 | $563 | $622,079 | 9 | Ster-Kinekor Pictures | false | false |
| 13 | 8 | Paul Blart: Mall Cop | $17,470 | -31.8% | 20 | -5 | $873 | $99,965 | 3 | Ster-Kinekor Pictures | false | false |
| 14 | 15 | Friday the 13th | $7,967 | -11.8% | 8 | -2 | $995 | $38,477 | 3 | United International Pictures | false | false |
| 15 | 12 | Defiance | $7,318 | -44.5% | 10 | - | $731 | $27,002 | 2 | United International Pictures | false | false |
| 16 | 11 | Rachel Getting Married | $5,832 | -56.4% | 9 | -1 | $648 | $47,346 | 3 | Ster-Kinekor Pictures | false | false |
| 17 | - | Aa Dekhen Zara | $5,665 | - | 3 | - | $1,888 | $5,665 | 1 | NuMetro Distribution | true | false |
| 18 | 13 | Seven Pounds | $5,605 | -52.9% | 15 | -5 | $373 | $300,511 | 7 | Ster-Kinekor Pictures | false | false |
| 19 | 19 | Notorious | $5,599 | -16.1% | 14 | -2 | $399 | $141,099 | 6 | NuMetro Distribution | false | false |
| 20 | 20 | The Secret Life of Bees | $5,444 | -6.7% | 13 | -6 | $418 | $180,752 | 8 | NuMetro Distribution | false | false |
| 21 | 14 | New in Town | $5,098 | -49.3% | 15 | -16 | $339 | $141,072 | 4 | NuMetro Distribution | false | false |
| 22 | 17 | Changeling | $4,752 | -40.2% | 8 | -4 | $594 | $183,718 | 6 | United International Pictures | false | false |
| 23 | - | Fanboys | $3,474 | - | 15 | - | $231 | $14,223 | 2 | Ster-Kinekor Pictures | false | false |
| 24 | 18 | Inkheart | $2,782 | -62.7% | 18 | - | $154 | $167,905 | 6 | NuMetro Distribution | false | false |
| 25 | - | Mr. Bones 2: Back from the Past | $1,599 | - | 7 | - | $228 | $3,655,844 | 18 | United International Pictures | false | false |
| 26 | 23 | Vicky Cristina Barcelona | $1,328 | -34.7% | 3 | - | $442 | $205,273 | 13 | United International Pictures | false | false |
| 27 | 24 | Revolutionary Road | $1,082 | -36.7% | 5 | -1 | $216 | $204,300 | 10 | United International Pictures | false | false |
| 28 | 22 | Transporter 3 | $928 | -55.5% | 4 | -5 | $232 | $769,016 | 11 | United International Pictures | false | false |
| 29 | 28 | Four Christmases | $159 | -15.4% | 1 | - | $159 | $508,332 | 12 | NuMetro Distribution | false | false |
| 30 | 29 | Burn After Reading | $101 | -33.1% | 1 | - | $101 | $277,773 | 12 | Ster-Kinekor Pictures | false | false |
| 31 | 30 | Appaloosa | $48 | -66.2% | 1 | - | $48 | $21,470 | 7 | NuMetro Distribution | false | false |
