| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Bedtime Stories | $53,213 | -22.8% | 33 | -3 | $1,612 | $876,626 | 6 | Walt Disney Pictures | false | false |
| 2 | 1 | Underworld: Rise of the Lycans | $46,509 | -38% | 30 | -1 | $1,550 | $143,649 | 2 | Sony Pictures Releasing | false | false |
| 3 | 3 | Gran Torino | $40,188 | -30% | 11 | -4 | $3,653 | $122,031 | 2 | Warner Bros. | false | false |
| 4 | 4 | Slumdog Millionaire | $35,090 | -34.1% | 19 | -2 | $1,846 | $549,932 | 6 | Bazuca Films | false | false |
| 5 | 5 | Changeling | $27,975 | -35% | 30 | -3 | $932 | $163,973 | 3 | United International Pictures | false | false |
| 6 | - | Confessions of a Shopaholic | $26,874 | - | 21 | - | $1,279 | $26,874 | 1 | Walt Disney Pictures | true | false |
| 7 | 8 | Impy's Island | $19,844 | +3.1% | 15 | - | $1,322 | $102,270 | 4 | Bazuca Films | false | false |
| 8 | 9 | Jonas Brothers: The 3D Concert Experience | $12,516 | -32.3% | 9 | +1 | $1,390 | $117,892 | 4 | Walt Disney Pictures | false | false |
| 9 | - | Reincarnation 2009 Re-release | $11,203 | - | 7 | - | $1,600 | $11,203 | 1 | Andes Films | true | false |
| 10 | 10 | He's Just Not That Into You | $10,998 | -28.7% | 7 | -2 | $1,571 | $229,679 | 7 | Warner Bros. | false | false |
| 11 | 6 | Valkyrie | $9,749 | -55.9% | 20 | -11 | $487 | $740,153 | 7 | 20th Century Fox International | false | false |
| 12 | - | Milk | $9,555 | - | 6 | - | $1,592 | $9,555 | 1 | United International Pictures | true | false |
| 13 | 14 | Friday the 13th | $9,024 | +2.7% | 22 | +9 | $410 | $241,112 | 7 | United International Pictures | false | false |
| 14 | 7 | Watchmen | $9,024 | -56.1% | 22 | -14 | $410 | $193,679 | 4 | United International Pictures | false | false |
| 15 | 12 | Doubt | $7,406 | -23% | 6 | - | $1,234 | $104,350 | 5 | Walt Disney Pictures | false | false |
| 16 | - | Planet Terror | $6,811 | - | 10 | - | $681 | $6,811 | 1 | Bazuca Films | true | false |
| 17 | 13 | The Curious Case of Benjamin Button | $6,588 | -30.6% | 12 | -2 | $549 | $1,051,062 | 10 | Warner Bros. | false | false |
| 18 | 16 | Hotel for Dogs | $5,571 | -9% | 8 | -1 | $696 | $254,380 | 10 | United International Pictures | false | false |
| 19 | 11 | Descendents | $4,127 | -72% | 16 | -5 | $257 | $23,478 | 2 | N/A | false | false |
| 20 | 17 | Righteous Kill | $3,552 | -28.7% | 8 | -1 | $444 | $65,678 | 4 | CDI Films | false | false |
| 21 | 18 | The Duchess | $2,806 | -23.5% | 2 | -1 | $1,403 | $64,867 | 6 | United International Pictures | false | false |
| 22 | 20 | Coraline | $2,331 | -22.8% | 8 | -1 | $291 | $317,434 | 8 | United International Pictures | false | false |
| 23 | - | Four Minutes | $2,263 | - | 2 | - | $1,131 | $2,263 | 1 | Transeuropa | true | false |
| 24 | 15 | Deception | $1,850 | -72.4% | 6 | -2 | $308 | $10,820 | 2 | Bazuca Films | false | false |
| 25 | 19 | Seven Pounds | $1,638 | -51.3% | 4 | -1 | $409 | $92,662 | 6 | Sony Pictures Releasing | false | false |
| 26 | 23 | Inkheart | $1,454 | -17.8% | 4 | -1 | $363 | $351,812 | 8 | Warner Bros. | false | false |
| 27 | 26 | Bolt | $1,003 | -31.3% | 3 | -6 | $334 | $1,707,167 | 14 | Walt Disney Pictures | false | false |
| 28 | 24 | The Strangers | $918 | -47.8% | 3 | -2 | $306 | $108,908 | 10 | Bazuca Films | false | false |
| 29 | 22 | The Boy in the Striped Pajamas | $727 | -63.5% | 2 | -2 | $363 | $247,813 | 11 | Walt Disney Pictures | false | false |
| 30 | 28 | Che: Part One | $585 | -52% | 2 | +1 | $292 | $122,577 | 9 | Bazuca Films | false | false |
| 31 | 33 | Family Hero | $485 | +70.2% | 2 | +1 | $242 | $27,335 | 7 | Andes Films | false | false |
| 32 | 27 | Yes Man | $420 | -70.2% | 1 | -1 | $420 | $929,148 | 11 | Warner Bros. | false | false |
| 33 | 31 | Beverly Hills Chihuahua | $371 | -0.8% | 3 | +1 | $123 | $553,710 | 12 | Walt Disney Pictures | false | false |
| 34 | - | Bride Wars | $342 | - | 1 | - | $342 | $146,672 | 9 | 20th Century Fox International | false | false |
| 35 | 21 | The Bank Job | $317 | -86.7% | 1 | -4 | $317 | $51,751 | 5 | Transeuropa | false | false |
| 36 | 30 | The Tale of Despereaux | $287 | -44.2% | 2 | - | $143 | $161,292 | 9 | United International Pictures | false | false |
| 37 | 34 | Twilight | $162 | -27.4% | 1 | - | $162 | $1,290,455 | 13 | Bazuca Films | false | false |
| 38 | 29 | Flawless | $160 | -69.9% | 1 | -2 | $160 | $23,553 | 5 | Bazuca Films | false | false |
