| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Knowing | $514,687 | - | 58 | - | $8,873 | $522,099 | 1 | Belga Films | true | false |
| 2 | - | Monsters vs. Aliens | $224,809 | - | 96 | - | $2,341 | $282,369 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 1 | Duplicity | $140,677 | -49.5% | 37 | - | $3,802 | $484,538 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 5 | Slumdog Millionaire | $124,497 | -17.9% | 39 | - | $3,192 | $2,837,893 | 12 | Cinéart | false | false |
| 5 | - | Beverly Hills Chihuahua | $113,606 | - | 52 | - | $2,184 | $114,179 | 1 | Walt Disney Pictures | true | false |
| 6 | - | Safari | $100,447 | - | 18 | - | $5,580 | $100,447 | 1 | Alternative Films | true | false |
| 7 | 4 | Confessions of a Shopaholic | $98,182 | -36% | 47 | -5 | $2,088 | $617,263 | 3 | Walt Disney Pictures | false | false |
| 8 | 2 | Coco | $95,694 | -49.8% | 21 | - | $4,556 | $687,560 | 3 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | S&M Judge | $93,346 | -33.6% | 19 | - | $4,912 | $637,750 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 10 | 3 | Marley & Me | $75,963 | -51.5% | 50 | - | $1,519 | $899,573 | 4 | 20th Century Fox International | false | false |
| 11 | 8 | District 13: Ultimatum | $58,417 | -44.4% | 13 | - | $4,493 | $192,027 | 2 | Belga Films | false | false |
| 12 | 7 | Red Cliff | $57,093 | -48.2% | 20 | -3 | $2,854 | $198,461 | 2 | Belga Films | false | false |
| 13 | 14 | The Reader | $38,646 | -39.2% | 20 | -5 | $1,932 | $620,626 | 5 | Benelux Film Distributors | false | false |
| 14 | 11 | Gran Torino | $35,882 | -53.8% | 25 | - | $1,435 | $927,078 | 6 | Warner Bros. | false | false |
| 15 | 10 | Watchmen | $32,567 | -64.9% | 35 | -12 | $930 | $1,125,969 | 5 | Universal Pictures International (UPI) | false | false |
| 16 | 13 | The Unborn | $29,124 | -55.3% | 15 | -2 | $1,941 | $226,669 | 3 | Universal Pictures International (UPI) | false | false |
| 17 | 17 | Welcome | $25,575 | -27.9% | 11 | - | $2,325 | $77,264 | 2 | Cinéart | false | false |
| 18 | 9 | Bolt | $25,275 | -73.8% | 70 | -4 | $361 | $2,870,857 | 8 | Walt Disney Pictures | false | false |
| 19 | 15 | The Curious Case of Benjamin Button | $20,747 | -59.7% | 29 | -13 | $715 | $3,231,444 | 9 | Warner Bros. | false | false |
| 20 | - | Katanga Business | $18,567 | - | 7 | - | $2,652 | $22,911 | 1 | Cinéart | true | false |
| 21 | 16 | The International | $16,426 | -63.5% | 21 | -9 | $782 | $322,608 | 4 | Sony Pictures Releasing | false | false |
| 22 | 12 | Hotel for Dogs | $16,049 | -76.5% | 39 | +3 | $411 | $1,106,958 | 7 | Universal Pictures International (UPI) | false | false |
| 23 | 18 | Milk | $14,569 | -43.1% | 12 | -3 | $1,214 | $313,905 | 6 | A-Film Distribution | false | false |
| 24 | 19 | The Burning Plain | $13,852 | -44.5% | 8 | -5 | $1,731 | $93,302 | 3 | Cinéart | false | false |
| 25 | - | The True Story of Puss'N Boots | $8,364 | - | 19 | - | $440 | $21,920 | 1 | N/A | true | false |
| 26 | 20 | Underworld: Rise of the Lycans | $7,321 | -67.8% | 3 | -2 | $2,440 | $65,935 | 3 | Sony Pictures Releasing | false | false |
| 27 | 23 | Loft | $6,729 | -46.3% | 23 | +4 | $292 | $9,671,439 | 24 | Independent Films | false | false |
| 28 | 25 | Defiance | $6,242 | -46.1% | 6 | -6 | $1,040 | $217,333 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 29 | - | Lemo | $6,197 | - | 23 | - | $269 | $6,197 | 1 | N/A | true | false |
| 30 | 27 | Seraphine | $5,700 | -43.9% | 9 | - | $633 | $268,313 | 24 | Cinéart | false | false |
| 31 | 21 | LOL (Laughing Out Loud) | $4,901 | -76.4% | 15 | -6 | $326 | $1,081,304 | 9 | Alternative Films | false | false |
| 32 | 22 | The Tale of Despereaux | $4,584 | -77.8% | 27 | -4 | $169 | $393,936 | 6 | Universal Pictures International (UPI) | false | false |
| 33 | 34 | The Beaches of Agnès | $3,658 | -27.5% | 2 | - | $1,829 | $35,220 | 4 | Cinéart | false | false |
| 34 | 26 | The Girl on the Train | $2,451 | -77.5% | 7 | -5 | $350 | $41,948 | 3 | Benelux Film Distributors | false | false |
| 35 | 32 | The Three Investigators and the Secret of Skeleton Island 2009 Re-release | $1,948 | -63.6% | 5 | - | $389 | $13,813 | 3 | Walt Disney Pictures | false | false |
| 36 | 36 | Princess Lillifee | $1,932 | -51.6% | 4 | - | $483 | $6,477 | 2 | Walt Disney Pictures | false | false |
| 37 | 24 | Le code a changé | $1,840 | -84.2% | 13 | -4 | $141 | $515,366 | 7 | Universal Pictures International (UPI) | false | false |
| 38 | 39 | Zack and Miri Make a Porno | $1,774 | -37.8% | 1 | -3 | $1,774 | $286,845 | 7 | Benelux Film Distributors | false | false |
| 39 | 38 | 24 City | $1,650 | -45.1% | 1 | - | $1,650 | $5,799 | 2 | Cinéart | false | false |
| 40 | 45 | Doubt | $1,600 | -17.4% | 4 | -3 | $400 | $323,776 | 8 | Walt Disney Pictures | false | false |
| 41 | 51 | The Secret of Kells | $1,267 | -18.1% | 3 | -5 | $422 | $43,323 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 42 | 46 | Tulpan | $1,216 | -28.3% | 2 | -4 | $608 | $15,662 | 5 | Benelux Film Distributors | false | false |
| 43 | 44 | Leonera | $1,067 | -45.3% | 4 | - | $266 | $6,424 | 2 | A-Film Distribution | false | false |
| 44 | 49 | Delta | $1,014 | -36% | 3 | - | $338 | $8,038 | 4 | Benelux Film Distributors | false | false |
| 45 | 31 | Twilight | $1,008 | -81.2% | 6 | -3 | $168 | $3,329,765 | 19 | Belga Films | false | false |
| 46 | 47 | The Fall | $957 | -42% | 1 | -2 | $957 | $8,731 | 4 | Paradiso Entertainment | false | false |
| 47 | 48 | Lilly the Witch: The Dragon and the Magic Book | $884 | -45.4% | 5 | - | $176 | $49,500 | 7 | Kinepolis Film Distribution (KFD) | false | false |
| 48 | 29 | Push | $616 | -91.7% | 1 | -3 | $616 | $144,030 | 5 | Belga Films | false | false |
| 49 | - | Igor | $550 | - | 4 | - | $137 | $550 | 1 | Kinepolis Film Distribution (KFD) | true | false |
| 50 | 56 | The Baader Meinhof Complex | $382 | -55.5% | 2 | -2 | $191 | $34,428 | 10 | A-Film Distribution | false | false |
| 51 | 61 | Dirty Mind | $309 | -44.5% | 7 | +4 | $44 | $204,933 | 10 | Kinepolis Film Distribution (KFD) | false | false |
| 52 | 30 | What Just Happened | $262 | -95.6% | 2 | -4 | $131 | $15,770 | 2 | Paradiso Entertainment | false | false |
| 53 | - | Enfances | $201 | - | 1 | - | $201 | $201 | 1 | N/A | true | false |
| 54 | 28 | Madagascar: Escape 2 Africa | $152 | -98.1% | 1 | -8 | $152 | $6,565,460 | 18 | Universal Pictures International (UPI) | false | false |
| 55 | 50 | The Secret of Moonacre | $146 | -90.6% | 3 | -2 | $48 | $69,920 | 7 | Kinepolis Film Distribution (KFD) | false | false |
| 56 | 57 | Mia and the Migoo | $142 | -82.3% | 3 | - | $47 | $14,399 | 7 | Benelux Film Distributors | false | false |
| 57 | 52 | Moscow, Belgium | $9 | -99.4% | 2 | - | $4 | $1,898,002 | 62 | Kinepolis Film Distribution (KFD) | false | false |
