| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Slumdog Millionaire | $108,876 | -19.3% | 20 | - | $5,443 | $315,360 | 2 | Ster-Kinekor Pictures | false | false |
| 2 | - | Confessions of a Shopaholic | $106,829 | - | 50 | - | $2,136 | $106,829 | 1 | Ster-Kinekor Pictures | true | false |
| 3 | 3 | The Pink Panther 2 | $67,837 | -29.5% | 69 | -6 | $983 | $379,929 | 3 | Ster-Kinekor Pictures | false | false |
| 4 | 2 | Watchmen | $67,232 | -39.2% | 62 | - | $1,084 | $222,747 | 2 | Ster-Kinekor Pictures | false | false |
| 5 | 4 | The Curious Case of Benjamin Button | $59,506 | -24.8% | 55 | - | $1,081 | $372,220 | 3 | NuMetro Distribution | false | false |
| 6 | 5 | He's Just Not That Into You | $45,910 | -21.6% | 51 | +1 | $900 | $612,326 | 5 | NuMetro Distribution | false | false |
| 7 | - | Paul Blart: Mall Cop | $35,998 | - | 25 | - | $1,439 | $35,998 | 1 | Ster-Kinekor Pictures | true | false |
| 8 | 7 | Bedtime Stories | $30,867 | -23.4% | 42 | -9 | $734 | $545,506 | 7 | Ster-Kinekor Pictures | false | false |
| 9 | 6 | New in Town | $29,734 | -40.2% | 53 | +3 | $561 | $103,349 | 2 | NuMetro Distribution | false | false |
| 10 | 11 | Seven Pounds | $17,465 | -4.3% | 20 | -14 | $873 | $275,999 | 5 | Ster-Kinekor Pictures | false | false |
| 11 | - | Rachel Getting Married | $16,987 | - | 10 | - | $1,698 | $16,987 | 1 | Ster-Kinekor Pictures | true | false |
| 12 | - | Friday the 13th | $13,269 | - | 10 | - | $1,326 | $13,269 | 1 | United International Pictures | true | false |
| 13 | 10 | Changeling | $13,174 | -31.2% | 20 | -6 | $658 | $154,961 | 4 | United International Pictures | false | false |
| 14 | 9 | Inkheart | $12,357 | -40.2% | 24 | -10 | $514 | $151,147 | 4 | NuMetro Distribution | false | false |
| 15 | 8 | Bride Wars | $11,260 | -54.2% | 29 | -18 | $388 | $785,479 | 8 | NuMetro Distribution | false | false |
| 16 | - | Passengers | $10,323 | - | 10 | - | $1,032 | $10,323 | 1 | NuMetro Distribution | true | false |
| 17 | 12 | Notorious | $8,018 | -44.5% | 16 | -6 | $501 | $115,031 | 4 | NuMetro Distribution | false | false |
| 18 | 14 | The Secret Life of Bees | $7,470 | -15.6% | 17 | -3 | $439 | $155,381 | 6 | NuMetro Distribution | false | false |
| 19 | 17 | Jonas Brothers: The 3D Concert Experience | $6,204 | -24.1% | 9 | - | $689 | $15,708 | 2 | Ster-Kinekor Pictures | false | false |
| 20 | 16 | The Longshots | $5,058 | -41.3% | 10 | -7 | $505 | $33,851 | 3 | Ster-Kinekor Pictures | false | false |
| 21 | 13 | Transporter 3 | $4,601 | -54% | 14 | -11 | $328 | $732,647 | 9 | United International Pictures | false | false |
| 22 | 18 | Role Models | $4,011 | -46.3% | 11 | -6 | $364 | $211,436 | 6 | United International Pictures | false | false |
| 23 | 23 | Revolutionary Road | $3,951 | -5.5% | 15 | +5 | $263 | $50,784 | 8 | United International Pictures | false | false |
| 24 | 21 | The Wrestler | $3,040 | -40% | 9 | +1 | $337 | $49,872 | 4 | United International Pictures | false | false |
| 25 | 15 | Mr. Bones 2: Back from the Past | $2,665 | -69.6% | 11 | -23 | $242 | $3,650,120 | 16 | United International Pictures | false | false |
| 26 | 25 | Frost/Nixon | $1,117 | -8.9% | 2 | - | $558 | $44,366 | 7 | United International Pictures | false | false |
