| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Gran Torino | $319,005 | -23.9% | 52 | +2 | $6,134 | $1,222,930 | 3 | Warner Bros. | false | false |
| 2 | 1 | Marley & Me | $300,706 | -36.6% | 83 | -5 | $3,622 | $853,400 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | Slumdog Millionaire | $285,394 | -20% | 36 | - | $7,927 | $3,438,408 | 10 | Pathé | false | false |
| 4 | 4 | The Reader | $210,592 | -17.8% | 30 | - | $7,019 | $568,051 | 4 | Ascot Elite Entertainment Group | false | false |
| 5 | - | Confessions of a Shopaholic | $165,671 | - | 44 | - | $3,765 | $213,223 | 3 | Walt Disney Pictures | false | false |
| 6 | 5 | Watchmen | $144,264 | -41.3% | 53 | +1 | $2,721 | $430,406 | 2 | N/A | false | false |
| 7 | - | The Unborn | $116,071 | - | 25 | - | $4,642 | $116,071 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 22 | The Pink Panther 2 | $105,683 | +579.2% | 4 | -3 | $26,420 | $195,718 | 4 | Walt Disney Pictures | false | false |
| 9 | 6 | Milk | $83,653 | -34.3% | 32 | - | $2,614 | $618,920 | 8 | Ascot Elite Entertainment Group | false | false |
| 10 | 7 | Yes Man | $78,414 | -36.6% | 24 | -5 | $3,267 | $1,205,794 | 10 | Warner Bros. | false | false |
| 11 | 8 | The Curious Case of Benjamin Button | $61,448 | -46.2% | 31 | -7 | $1,982 | $2,889,540 | 7 | Warner Bros. | false | false |
| 12 | 11 | Hotel for Dogs | $58,148 | -32.9% | 49 | +2 | $1,186 | $825,485 | 6 | Universal Pictures International (UPI) | false | false |
| 13 | 9 | Twilight | $58,127 | -42.9% | 32 | -7 | $1,816 | $2,841,467 | 17 | Ascot Elite Entertainment Group | false | false |
| 14 | 17 | The International | $52,599 | +37.5% | 16 | - | $3,287 | $623,776 | 5 | Walt Disney Pictures | false | false |
| 15 | 10 | He's Just Not That Into You | $51,434 | -43.3% | 22 | -7 | $2,337 | $790,131 | 5 | Warner Bros. | false | false |
| 16 | 12 | Lilly the Witch: The Dragon and the Magic Book | $50,563 | -37% | 42 | -3 | $1,203 | $404,139 | 4 | Walt Disney Pictures | false | false |
| 17 | 15 | Home | $49,065 | +1.9% | 15 | +3 | $3,271 | $808,467 | 22 | Filmcoopi | false | false |
| 18 | - | Mid-August Lunch | $42,602 | - | 6 | - | $7,100 | $96,104 | 15 | Xenix Filmdistribution | false | false |
| 19 | 16 | Revolutionary Road | $35,840 | -11% | 24 | +1 | $1,493 | $2,202,210 | 9 | Universal Pictures International (UPI) | false | false |
| 20 | 14 | The Wrestler | $31,001 | -40.8% | 15 | -5 | $2,066 | $262,176 | 4 | Frenetic Films | false | false |
| 21 | 24 | Frost/Nixon | $5,832 | -32.6% | 3 | -1 | $1,944 | $171,578 | 5 | Universal Pictures International (UPI) | false | false |
| 22 | - | Friday the 13th | $5,497 | - | 8 | - | $687 | $312,741 | 5 | Universal Pictures International (UPI) | false | false |
| 23 | 25 | The Tale of Despereaux | $4,099 | -51.8% | 12 | - | $341 | $87,732 | 5 | Universal Pictures International (UPI) | false | false |
| 24 | 19 | Role Models | $3,735 | -87.6% | 13 | -14 | $287 | $125,482 | 3 | Universal Pictures International (UPI) | false | false |
| 25 | 27 | Fly Me to the Moon 3D | $3,205 | -11.1% | 1 | - | $3,205 | $119,047 | 20 | N/A | false | false |
| 26 | 23 | Changeling | $2,497 | -78.9% | 8 | -3 | $312 | $1,456,690 | 18 | Universal Pictures International (UPI) | false | false |
| 27 | 26 | Madagascar: Escape 2 Africa | $2,158 | -71.8% | 4 | -9 | $539 | $11,010,678 | 15 | Universal Pictures International (UPI) | false | false |
