| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Slumdog Millionaire | $29,494 | -4.4% | 6 | +5 | $4,915 | $131,421 | 3 | N/A | false | false |
| 2 | - | Seven Pounds | $14,748 | - | 6 | - | $2,458 | $14,748 | 1 | N/A | true | false |
| 3 | 3 | The Curious Case of Benjamin Button | $6,925 | -54.6% | 5 | -2 | $1,385 | $177,483 | 6 | N/A | false | false |
| 4 | 2 | The Pink Panther 2 | $6,925 | -68% | 5 | -5 | $1,385 | $69,842 | 3 | Sony Pictures Releasing | false | false |
| 5 | 4 | Bedtime Stories | $6,040 | -53% | 6 | - | $1,006 | $113,874 | 5 | N/A | false | false |
| 6 | 5 | Vicky Cristina Barcelona | $5,215 | -47.8% | 7 | - | $745 | $197,407 | 5 | N/A | false | false |
| 7 | 13 | Milk | $4,905 | +45.3% | 6 | +1 | $817 | $36,909 | 4 | N/A | false | false |
| 8 | 6 | Marley & Me | $4,330 | -55.2% | 4 | - | $1,082 | $84,842 | 4 | N/A | false | false |
| 9 | 8 | The Wrestler | $2,821 | -59.5% | 3 | - | $940 | $13,732 | 2 | N/A | false | false |
| 10 | 11 | U2 3D | $2,634 | -30% | 1 | - | $2,634 | $30,937 | 4 | N/A | false | false |
| 11 | 14 | In Bruges | $2,261 | -27.6% | 2 | - | $1,130 | $25,038 | 4 | N/A | false | false |
| 12 | 12 | Bolt | $2,114 | -37.9% | 3 | -1 | $704 | $154,519 | 9 | N/A | false | false |
| 13 | 9 | Yes Man | $2,045 | -60% | 3 | - | $681 | $143,458 | 7 | N/A | false | false |
| 14 | 7 | The Tale of Despereaux | $1,765 | -75.2% | 6 | - | $294 | $12,807 | 2 | N/A | false | false |
| 15 | 15 | Changeling | $1,675 | -37.6% | 2 | -1 | $837 | $123,419 | 7 | N/A | false | false |
| 16 | 10 | Valkyrie | $1,463 | -62.4% | 3 | - | $487 | $84,840 | 6 | N/A | false | false |
| 17 | 18 | Doubt | $1,108 | -39% | 2 | - | $554 | $45,339 | 7 | N/A | false | false |
| 18 | 20 | Revolutionary Road | $1,052 | -22.1% | 1 | - | $1,052 | $40,759 | 5 | N/A | false | false |
| 19 | 19 | Madagascar: Escape 2 Africa | $691 | -60.9% | 3 | - | $230 | $277,264 | 13 | Paramount Pictures International | false | false |
| 20 | 22 | Twilight | $571 | -47.6% | 3 | - | $190 | $106,674 | 9 | N/A | false | false |
| 21 | 21 | Che: Part One | $420 | -62.1% | 1 | -1 | $420 | $29,963 | 6 | N/A | false | false |
| 22 | 23 | Tonky y Otros Amigos | $410 | -59.1% | 3 | - | $136 | $1,956 | 2 | N/A | false | false |
| 23 | 25 | My Brother is an Only Child | $315 | -0.6% | 1 | - | $315 | $17,254 | 13 | N/A | false | false |
| 24 | 16 | Frost/Nixon | $250 | -90.3% | 1 | -2 | $250 | $7,612 | 3 | N/A | false | false |
| 25 | 24 | The Bank Job | $244 | -59.5% | 1 | -1 | $244 | $42,105 | 8 | N/A | false | false |
| 26 | 26 | Frozen River | $194 | -5.8% | 1 | - | $194 | $2,278 | 4 | N/A | false | false |
| 27 | 27 | Space Chimps | $135 | +15.4% | 2 | - | $67 | $3,052 | 5 | N/A | false | false |
