| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 5 | Slumdog Millionaire | $219,746 | +38.8% | 44 | +3 | $4,994 | $652,531 | 3 | Distribution Company | false | false |
| 2 | 2 | Bedtime Stories | $171,634 | -42.6% | 76 | +8 | $2,258 | $1,682,089 | 4 | Walt Disney Pictures | false | false |
| 3 | 1 | The Curious Case of Benjamin Button | $159,514 | -48.1% | 60 | -5 | $2,658 | $1,670,355 | 4 | Warner Bros. | false | false |
| 4 | - | Bride Wars | $106,676 | - | 42 | - | $2,539 | $106,676 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | Hotel for Dogs | $96,247 | -51.4% | 43 | +3 | $2,238 | $365,974 | 2 | Paramount Pictures International | false | false |
| 6 | 4 | Valkyrie | $89,656 | -50.6% | 66 | +7 | $1,358 | $607,702 | 3 | 20th Century Fox International | false | false |
| 7 | 6 | Vicky Cristina Barcelona | $80,449 | -25.7% | 39 | +5 | $2,062 | $605,520 | 4 | Pachamama Cine | false | false |
| 8 | - | Seven Pounds | $71,096 | - | 28 | - | $2,539 | $71,096 | 1 | Sony Pictures Releasing | true | false |
| 9 | 9 | The Pink Panther 2 | $45,163 | -44.3% | 25 | -2 | $1,806 | $152,029 | 2 | Sony Pictures Releasing | false | false |
| 10 | 10 | Friday the 13th | $35,684 | -53.5% | 31 | +1 | $1,151 | $268,830 | 3 | Paramount Pictures International | false | false |
| 11 | 12 | Changeling | $35,651 | -33.9% | 47 | +3 | $758 | $884,184 | 6 | Universal Pictures International (UPI) | false | false |
| 12 | 14 | Milk | $34,981 | -9.6% | 32 | +5 | $1,093 | $176,657 | 3 | Universal Pictures International (UPI) | false | false |
| 13 | 7 | The Wrestler | $34,838 | -62% | 30 | - | $1,161 | $151,505 | 2 | Distribution Company | false | false |
| 14 | 11 | Yes Man | $34,359 | -50.8% | 54 | - | $636 | $1,302,870 | 7 | Warner Bros. | false | false |
| 15 | 13 | Underworld: Rise of the Lycans | $25,141 | -52.5% | 21 | -9 | $1,197 | $349,629 | 4 | Sony Pictures Releasing | false | false |
| 16 | - | Death Proof | $18,807 | - | 14 | - | $1,343 | $18,807 | 1 | Pachamama Cine | true | false |
| 17 | 15 | Doubt | $17,791 | -47.5% | 23 | - | $773 | $529,531 | 7 | Walt Disney Pictures | false | false |
| 18 | 8 | Bolt | $15,226 | -83.4% | 67 | -17 | $227 | $2,242,034 | 7 | Walt Disney Pictures | false | false |
| 19 | 16 | Revolutionary Road | $12,788 | -48.7% | 27 | +4 | $473 | $288,722 | 5 | Paramount Pictures International | false | false |
| 20 | 19 | The Tale of Despereaux | $7,398 | -48.6% | 37 | - | $199 | $181,810 | 4 | United International Pictures | false | false |
| 21 | - | L'année suivante | $6,190 | - | 2 | - | $3,095 | $6,190 | 1 | Zeta Films | true | false |
| 22 | 18 | Marley & Me | $5,438 | -73.1% | 26 | -24 | $209 | $655,450 | 6 | 20th Century Fox International | false | false |
| 23 | 17 | Frost/Nixon | $5,171 | -78% | 7 | -8 | $738 | $37,454 | 2 | United International Pictures | false | false |
| 24 | 21 | Inkheart | $3,779 | -58.7% | 31 | -1 | $121 | $371,314 | 5 | Distribution Company | false | false |
| 25 | 20 | Australia | $3,400 | -73.6% | 15 | -17 | $226 | $841,639 | 8 | 20th Century Fox International | false | false |
| 26 | - | Am Ende kommen Touristen | $3,249 | - | 4 | - | $812 | $11,491 | 2 | Alfa Films | false | false |
| 27 | 22 | Twilight | $1,931 | -71.9% | 12 | -3 | $160 | $1,879,884 | 9 | Alfa Films | false | false |
| 28 | - | Journey to the Center of the Earth | $1,568 | - | 1 | - | $1,568 | $1,308,100 | 33 | Distribution Company | false | false |
| 29 | 26 | The Day the Earth Stood Still | $1,014 | -25.5% | 11 | +2 | $92 | $1,955,094 | 9 | 20th Century Fox International | false | false |
| 30 | 24 | Madagascar: Escape 2 Africa | $930 | -76% | 12 | -2 | $77 | $5,391,878 | 13 | Paramount Pictures International | false | false |
| 31 | 35 | U2 3D | $920 | +98.7% | 1 | - | $920 | $140,764 | 49 | IMAX | false | false |
| 32 | 28 | Aniceto | $791 | -40.8% | 2 | -1 | $395 | $137,656 | 38 | Primer Plano Film Group | false | false |
| 33 | 30 | The Duchess | $654 | -25.9% | 5 | - | $130 | $261,574 | 12 | United International Pictures | false | false |
| 34 | 32 | Che: Part One | $625 | -18.3% | 5 | +2 | $125 | $668,975 | 16 | Alfa Films | false | false |
| 35 | 39 | Blame it on Fidel | $550 | +75.2% | 2 | +1 | $275 | $36,095 | 6 | Zeta Films | false | false |
| 36 | 27 | El ratón Pérez 2 | $402 | -70.4% | 5 | -1 | $80 | $724,384 | 9 | Walt Disney Pictures | false | false |
| 37 | 31 | Emma's Bliss | $387 | -54.4% | 2 | -1 | $193 | $26,620 | 5 | Primer Plano Film Group | false | false |
| 38 | 49 | Righteous Kill | $355 | +211.4% | 1 | - | $355 | $580,788 | 15 | CDI Films | false | false |
| 39 | 36 | The Camera Obscura 2008 Re-release | $336 | -21.9% | 1 | - | $336 | $64,271 | 20 | Distribution Company | false | false |
| 40 | 34 | La próxima estación | $331 | -30.6% | 2 | - | $165 | $120,249 | 26 | Primer Plano Film Group | false | false |
| 41 | - | The Spirit | $256 | - | 3 | - | $85 | $99,706 | 6 | Sony Pictures Releasing | false | false |
| 42 | 25 | Body of Lies | $241 | -91.1% | 1 | -5 | $241 | $929,392 | 14 | Warner Bros. | false | false |
| 43 | 48 | Late Bloomers | $150 | +5.6% | 1 | - | $150 | $77,898 | 14 | Primer Plano Film Group | false | false |
| 44 | - | Fly Me to the Moon 3D | $145 | - | 2 | - | $72 | $128,266 | 11 | Distribution Company | false | false |
| 45 | 43 | Café de los maestros | $144 | -35.1% | 1 | - | $144 | $94,126 | 36 | Alfa Films | false | false |
| 46 | 38 | W. | $140 | -65.3% | 3 | - | $46 | $67,336 | 7 | Impacto Cine | false | false |
| 47 | - | The Paranoids | $122 | - | 1 | - | $122 | $38,597 | 19 | Primer Plano Film Group | false | false |
| 48 | 40 | The Pope's Toilet | $111 | -61.3% | 1 | -1 | $111 | $28,180 | 9 | Primer Plano Film Group | false | false |
| 49 | 29 | Rudo y Cursi | $109 | -87.7% | 2 | -2 | $54 | $310,389 | 8 | United International Pictures | false | false |
| 50 | - | La leyenda | $101 | - | 1 | - | $101 | $206,591 | 15 | United International Pictures | false | false |
| 51 | 37 | Four Christmases | $76 | -82.1% | 1 | - | $76 | $419,584 | 11 | Distribution Company | false | false |
| 52 | 23 | Bangkok Dangerous | $69 | -98.5% | 1 | -8 | $69 | $125,330 | 7 | Distribution Company | false | false |
| 53 | 45 | Death Defying Acts | $47 | -76.8% | 1 | - | $47 | $115,845 | 14 | Alfa Films | false | false |
| 54 | 53 | Saw V | $34 | -12.8% | 2 | +1 | $17 | $1,076,655 | 18 | Walt Disney Pictures | false | false |
| 55 | 33 | RocknRolla | $31 | -94.6% | 1 | - | $31 | $92,024 | 12 | Warner Bros. | false | false |
