| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 3 | Slumdog Millionaire | $416,498 | +58.2% | 35 | +4 | $11,899 | $2,546,935 | 8 | Pathé | false | false |
| 2 | - | Gran Torino | $295,924 | - | 23 | - | $12,866 | $295,924 | 1 | Warner Bros. | true | false |
| 3 | 1 | The Curious Case of Benjamin Button | $230,436 | -34% | 57 | -9 | $4,042 | $2,632,053 | 5 | Warner Bros. | false | false |
| 4 | 2 | Yes Man | $212,460 | -27.2% | 43 | -9 | $4,940 | $946,217 | 8 | Warner Bros. | false | false |
| 5 | 4 | Twilight | $153,157 | -35.8% | 63 | -10 | $2,431 | $2,629,309 | 15 | Ascot Elite Entertainment Group | false | false |
| 6 | 6 | He's Just Not That Into You | $142,066 | +1.1% | 36 | +4 | $3,946 | $579,940 | 3 | Warner Bros. | false | false |
| 7 | 9 | Milk | $107,074 | -18.2% | 24 | +1 | $4,461 | $320,809 | 6 | Ascot Elite Entertainment Group | false | false |
| 8 | 5 | Bolt | $106,908 | -30.3% | 60 | -8 | $1,781 | $1,643,417 | 14 | Walt Disney Pictures | false | false |
| 9 | 7 | Hotel for Dogs | $85,036 | -37.3% | 38 | -11 | $2,237 | $665,096 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 11 | Lilly the Witch: The Dragon and the Magic Book | $82,187 | -24.8% | 44 | +1 | $1,867 | $232,944 | 2 | Walt Disney Pictures | false | false |
| 11 | 8 | The International | $80,751 | -39.7% | 28 | -8 | $2,883 | $506,931 | 3 | Walt Disney Pictures | false | false |
| 12 | 20 | The Wrestler | $80,549 | +72.4% | 20 | +13 | $4,027 | $135,147 | 2 | Frenetic Films | false | false |
| 13 | - | Role Models | $78,875 | - | 29 | - | $2,719 | $78,875 | 1 | Universal Pictures International (UPI) | true | false |
| 14 | - | Killing is My Business, Honey | $75,259 | - | 22 | - | $3,420 | $75,259 | 1 | Warner Bros. | true | false |
| 15 | 10 | Revolutionary Road | $63,488 | -42.1% | 33 | -7 | $1,923 | $2,058,941 | 7 | Universal Pictures International (UPI) | false | false |
| 16 | - | Defiance | $47,511 | - | 18 | - | $2,639 | $61,600 | 6 | Ascot Elite Entertainment Group | false | false |
| 17 | 15 | Home | $46,216 | -33.2% | 9 | -3 | $5,135 | $670,328 | 20 | Filmcoopi | false | false |
| 18 | - | Marcello Marcello | $40,845 | - | 12 | - | $3,403 | $355,123 | 28 | Filmcoopi | false | false |
| 19 | 16 | Australia | $38,327 | -39.4% | 17 | -5 | $2,254 | $5,182,524 | 10 | 20th Century Fox International | false | false |
| 20 | 18 | Transporter 3 | $33,955 | -31.8% | 13 | -1 | $2,611 | $642,210 | 9 | JMH Distribution | false | false |
| 21 | 14 | Friday the 13th | $30,027 | -57.5% | 23 | -4 | $1,305 | $291,662 | 3 | Universal Pictures International (UPI) | false | false |
| 22 | 21 | Frost/Nixon | $23,844 | -45.4% | 15 | -10 | $1,589 | $149,294 | 3 | Universal Pictures International (UPI) | false | false |
| 23 | 22 | The Pink Panther 2 | $22,594 | -48.2% | 13 | -1 | $1,738 | $72,175 | 2 | Walt Disney Pictures | false | false |
| 24 | 26 | The Tale of Despereaux | $16,173 | -21.9% | 16 | - | $1,010 | $74,492 | 3 | Universal Pictures International (UPI) | false | false |
| 25 | 23 | Changeling | $16,140 | -46.7% | 10 | -4 | $1,614 | $1,434,910 | 16 | Universal Pictures International (UPI) | false | false |
| 26 | 29 | The Reader | $5,344 | +15.2% | 1 | - | $5,344 | $12,505 | 2 | Ascot Elite Entertainment Group | false | false |
| 27 | 30 | Fly Me to the Moon 3D | $2,474 | -12.4% | 1 | - | $2,474 | $108,462 | 18 | N/A | false | false |
| 28 | 27 | Seven Pounds | $2,394 | -80% | 4 | -6 | $598 | $1,666,823 | 8 | Sony Pictures Releasing | false | false |
| 29 | 31 | Burn After Reading | $1,910 | -30.8% | 2 | - | $955 | $3,019,270 | 24 | Ascot Elite Entertainment Group | false | false |
