| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $349,162 | -25.4% | 66 | -12 | $5,290 | $2,335,243 | 4 | Warner Bros. | false | false |
| 2 | 20 | Yes Man | $291,955 | +768.3% | 52 | +40 | $5,614 | $679,893 | 7 | Warner Bros. | false | false |
| 3 | 3 | Slumdog Millionaire | $263,292 | +3.6% | 31 | - | $8,493 | $1,991,963 | 7 | Pathé | false | false |
| 4 | 2 | Twilight | $238,678 | -33.7% | 73 | -9 | $3,269 | $2,441,731 | 14 | Ascot Elite Entertainment Group | false | false |
| 5 | 5 | Bolt | $153,383 | -19.7% | 68 | -5 | $2,255 | $1,501,761 | 13 | Walt Disney Pictures | false | false |
| 6 | 6 | He's Just Not That Into You | $140,517 | -26.2% | 32 | -1 | $4,391 | $388,112 | 2 | Warner Bros. | false | false |
| 7 | 9 | Hotel for Dogs | $135,601 | -13.6% | 49 | +4 | $2,767 | $540,431 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | 4 | The International | $133,915 | -37.4% | 36 | - | $3,719 | $393,607 | 2 | Walt Disney Pictures | false | false |
| 9 | 26 | Milk | $130,890 | +8,539.6% | 23 | +22 | $5,690 | $167,633 | 5 | Ascot Elite Entertainment Group | false | false |
| 10 | 8 | Revolutionary Road | $109,740 | -32.9% | 40 | - | $2,743 | $1,983,460 | 6 | Universal Pictures International (UPI) | false | false |
| 11 | - | Lilly the Witch: The Dragon and the Magic Book | $109,323 | - | 43 | - | $2,542 | $109,323 | 1 | Walt Disney Pictures | true | false |
| 12 | 10 | Bride Wars | $82,513 | -33.3% | 32 | -6 | $2,578 | $473,983 | 3 | 20th Century Fox International | false | false |
| 13 | - | Le code a changé | $81,556 | - | 8 | - | $10,194 | $81,556 | 1 | Frenetic Films | true | false |
| 14 | 7 | Friday the 13th | $70,619 | -57.3% | 27 | +2 | $2,615 | $257,613 | 2 | Universal Pictures International (UPI) | false | false |
| 15 | - | Home | $69,237 | - | 12 | - | $5,769 | $608,021 | 19 | Filmcoopi | false | false |
| 16 | 12 | Australia | $63,260 | -32.4% | 22 | -11 | $2,875 | $5,187,873 | 9 | 20th Century Fox International | false | false |
| 17 | 14 | Doubt | $55,333 | -26.9% | 17 | +1 | $3,254 | $252,857 | 4 | Walt Disney Pictures | false | false |
| 18 | 13 | Transporter 3 | $49,751 | -37.1% | 14 | +2 | $3,553 | $602,394 | 8 | JMH Distribution | false | false |
| 19 | - | District 13: Ultimatum | $48,645 | - | 5 | - | $9,729 | $48,645 | 1 | Pathé | true | false |
| 20 | - | The Wrestler | $46,729 | - | 7 | - | $6,675 | $46,729 | 1 | Frenetic Films | true | false |
| 21 | 16 | Frost/Nixon | $43,710 | -13.9% | 25 | +6 | $1,748 | $115,368 | 2 | Universal Pictures International (UPI) | false | false |
| 22 | - | The Pink Panther 2 | $43,601 | - | 14 | - | $3,114 | $43,601 | 1 | Walt Disney Pictures | true | false |
| 23 | 15 | Changeling | $30,281 | -43.6% | 14 | -10 | $2,162 | $1,411,990 | 15 | Universal Pictures International (UPI) | false | false |
| 24 | 17 | Madagascar: Escape 2 Africa | $28,580 | -34.9% | 33 | -11 | $866 | $10,981,399 | 12 | Universal Pictures International (UPI) | false | false |
| 25 | 11 | Valkyrie | $23,837 | -75.6% | 10 | -35 | $2,383 | $1,170,916 | 5 | 20th Century Fox International | false | false |
| 26 | 21 | The Tale of Despereaux | $20,719 | -21.8% | 16 | +2 | $1,294 | $53,388 | 2 | Universal Pictures International (UPI) | false | false |
| 27 | 22 | Seven Pounds | $11,942 | -42.8% | 10 | -3 | $1,194 | $1,636,760 | 7 | Sony Pictures Releasing | false | false |
| 28 | 23 | The Spirit | $4,833 | -69.2% | 8 | -7 | $604 | $177,514 | 9 | Walt Disney Pictures | false | false |
| 29 | - | The Reader | $4,637 | - | 1 | - | $4,637 | $4,637 | 1 | Ascot Elite Entertainment Group | true | false |
| 30 | 25 | Fly Me to the Moon 3D | $2,825 | +4.1% | 1 | - | $2,825 | $101,366 | 17 | N/A | false | false |
| 31 | 24 | Burn After Reading | $2,762 | -44.7% | 2 | -2 | $1,381 | $3,017,097 | 23 | Ascot Elite Entertainment Group | false | false |
