| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Bedtime Stories | $90,118 | -20.5% | 55 | - | $1,638 | $237,997 | 2 | Ster-Kinekor Pictures | false | false |
| 2 | 2 | Bride Wars | $80,511 | -26.1% | 60 | - | $1,341 | $492,070 | 3 | NuMetro Distribution | false | false |
| 3 | 3 | Valkyrie | $63,892 | -28.1% | 49 | -1 | $1,303 | $203,710 | 2 | NuMetro Distribution | false | false |
| 4 | - | Role Models | $53,783 | - | 44 | - | $1,222 | $53,783 | 1 | United International Pictures | true | false |
| 5 | 4 | Transporter 3 | $53,683 | -24.5% | 69 | - | $778 | $594,225 | 4 | United International Pictures | false | false |
| 6 | - | The Secret Life of Bees | $36,779 | - | 25 | - | $1,471 | $36,779 | 1 | NuMetro Distribution | true | false |
| 7 | 5 | Yes Man | $30,319 | -27% | 54 | -4 | $561 | $855,960 | 6 | NuMetro Distribution | false | false |
| 8 | 10 | The Duchess | $21,391 | -11.7% | 12 | - | $1,782 | $61,934 | 2 | Ster-Kinekor Pictures | false | false |
| 9 | 9 | Twilight | $21,010 | -23% | 38 | -3 | $552 | $809,976 | 8 | NuMetro Distribution | false | false |
| 10 | 8 | Revolutionary Road | $20,811 | -24.7% | 18 | - | $1,156 | $134,579 | 3 | United International Pictures | false | false |
| 11 | 6 | Mr. Bones 2: Back from the Past | $19,608 | -36% | 40 | -10 | $490 | $3,581,271 | 11 | United International Pictures | false | false |
| 12 | 7 | Four Christmases | $18,446 | -33.4% | 37 | -2 | $498 | $467,792 | 5 | NuMetro Distribution | false | false |
| 13 | - | My Bloody Valentine | $17,785 | - | 9 | - | $1,976 | $17,785 | 1 | NuMetro Distribution | true | false |
| 14 | - | Doubt | $17,689 | - | 10 | - | $1,768 | $17,689 | 1 | Ster-Kinekor Pictures | true | false |
| 15 | 11 | Burn After Reading | $16,447 | -27.2% | 22 | - | $747 | $277,155 | 5 | Ster-Kinekor Pictures | false | false |
| 16 | 13 | RocknRolla | $13,406 | -23% | 19 | -1 | $705 | $50,552 | 2 | NuMetro Distribution | false | false |
| 17 | - | Happy-Go-Lucky | $9,214 | - | 10 | - | $921 | $9,214 | 1 | United International Pictures | true | false |
| 18 | 17 | Frost/Nixon | $8,301 | -10.2% | 10 | - | $830 | $23,179 | 2 | United International Pictures | false | false |
| 19 | 15 | Saw V | $7,257 | -34.7% | 19 | -1 | $381 | $117,400 | 4 | Ster-Kinekor Pictures | false | false |
| 20 | 18 | Vicky Cristina Barcelona | $7,030 | -21.5% | 10 | -3 | $703 | $169,098 | 6 | United International Pictures | false | false |
| 21 | 19 | Madagascar: Escape 2 Africa | $6,878 | -16.1% | 15 | -6 | $458 | $2,171,880 | 10 | United International Pictures | false | false |
| 22 | 12 | Bolt | $5,957 | -66.1% | 19 | -13 | $313 | $956,629 | 7 | Ster-Kinekor Pictures | false | false |
| 23 | 22 | Ghost Town | $4,139 | -20.4% | 10 | - | $413 | $12,430 | 2 | United International Pictures | false | false |
| 24 | 21 | Igor | $4,024 | -26.6% | 13 | -7 | $309 | $26,728 | 3 | Ster-Kinekor Pictures | false | false |
| 25 | 16 | Killshot | $3,085 | -71.4% | 13 | -12 | $237 | $54,977 | 3 | Ster-Kinekor Pictures | false | false |
| 26 | 24 | Pride and Glory | $2,115 | -28.5% | 14 | - | $151 | $215,527 | 6 | NuMetro Distribution | false | false |
| 27 | - | In Bruges | $107 | - | 1 | - | $107 | $154,120 | 21 | Ster-Kinekor Pictures | false | false |
