| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Yes Man | $340,864 | -30.3% | 60 | - | $5,681 | $1,923,265 | 3 | Warner Bros. | false | false |
| 2 | - | The Curious Case of Benjamin Button | $289,042 | - | 41 | - | $7,049 | $289,058 | 1 | N/A | true | false |
| 3 | - | Bride Wars | $234,097 | - | 41 | - | $5,709 | $234,097 | 1 | N/A | true | false |
| 4 | 2 | Hotel for Dogs | $147,116 | -38.3% | 45 | +2 | $3,269 | $843,419 | 3 | N/A | false | false |
| 5 | 3 | Seven Pounds | $103,468 | -37% | 35 | +1 | $2,956 | $1,087,389 | 4 | N/A | false | false |
| 6 | 4 | Marley & Me | $55,937 | -59.7% | 27 | -13 | $2,071 | $1,059,626 | 4 | N/A | false | false |
| 7 | - | The Spirit | $55,194 | - | 25 | - | $2,207 | $55,194 | 1 | N/A | true | false |
| 8 | 5 | Revolutionary Road | $38,122 | -39.4% | 18 | +2 | $2,117 | $163,855 | 2 | N/A | false | false |
| 9 | 6 | Mad Money | $33,800 | -45.4% | 15 | - | $2,253 | $137,693 | 2 | N/A | false | false |
| 10 | 8 | Changeling | $32,780 | -35.6% | 21 | -1 | $1,560 | $254,197 | 3 | N/A | false | false |
| 11 | 7 | Quarantine | $21,015 | -63.8% | 18 | -2 | $1,167 | $237,332 | 3 | N/A | false | false |
| 12 | 9 | Twilight | $20,919 | -58.4% | 16 | -10 | $1,307 | $2,742,817 | 8 | N/A | false | false |
| 13 | 11 | Bolt | $18,975 | -53.9% | 27 | -5 | $702 | $2,213,873 | 8 | N/A | false | false |
| 14 | 12 | Lonely Hearts | $15,262 | -57% | 11 | -1 | $1,387 | $84,081 | 2 | N/A | false | false |
| 15 | 13 | The Abandoned | $14,618 | -56.3% | 10 | -2 | $1,461 | $341,956 | 5 | N/A | false | false |
| 16 | 10 | Free Style | $14,250 | -66.9% | 17 | -2 | $838 | $86,491 | 2 | N/A | false | false |
| 17 | 14 | The Marsh | $11,693 | -56.5% | 7 | -3 | $1,670 | $299,925 | 5 | N/A | false | false |
| 18 | 16 | Bangkok Dangerous | $8,544 | -57.6% | 11 | +1 | $776 | $340,444 | 4 | N/A | false | false |
| 19 | 15 | Madagascar: Escape 2 Africa | $8,050 | -64.3% | 22 | -8 | $365 | $5,435,728 | 9 | N/A | false | false |
| 20 | 17 | Bella | $7,642 | -22.4% | 5 | +1 | $1,528 | $30,491 | 2 | N/A | false | false |
| 21 | 18 | A mi me gusta | $3,428 | -62.4% | 2 | -3 | $1,714 | $575,696 | 9 | N/A | false | false |
| 22 | 19 | The Tale of Despereaux | $2,260 | -69.1% | 9 | -5 | $251 | $756,777 | 6 | N/A | false | false |
| 23 | 21 | Burn After Reading | $1,269 | -60.5% | 2 | -4 | $634 | $371,749 | 5 | N/A | false | false |
| 24 | 24 | Four Christmases | $1,150 | +371.3% | 1 | -3 | $1,150 | $1,231,687 | 7 | N/A | false | false |
| 25 | 26 | Max Payne | $672 | +903% | 1 | - | $672 | $620,977 | 6 | N/A | false | false |
| 26 | - | Silent Light | $309 | - | 1 | - | $309 | $309 | 1 | N/A | true | false |
