| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $631,450 | -7.1% | 89 | +1 | $7,094 | $1,528,362 | 2 | Warner Bros. | false | false |
| 2 | 2 | Valkyrie | $469,026 | -28.9% | 97 | +1 | $4,835 | $2,408,798 | 3 | Warner Bros. | false | false |
| 3 | - | Spy of Orange | $434,754 | - | 107 | - | $4,063 | $434,754 | 1 | A-Film Distribution | true | false |
| 4 | 3 | Yes Man | $268,399 | -25.3% | 84 | -4 | $3,195 | $3,097,431 | 5 | Warner Bros. | false | false |
| 5 | - | The Tale of Despereaux | $242,080 | - | 69 | - | $3,508 | $299,890 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 5 | Australia | $150,123 | -24.3% | 87 | -9 | $1,725 | $3,912,899 | 8 | Warner Bros. | false | false |
| 7 | 4 | Winter in Wartime | $139,036 | -31.1% | 96 | -4 | $1,448 | $7,183,234 | 11 | Benelux Film Distributors | false | false |
| 8 | - | Make It Happen | $113,045 | - | 15 | - | $7,536 | $118,128 | 1 | Benelux Film Distributors | true | false |
| 9 | 8 | Gomorrah | $109,545 | -6.6% | 24 | +1 | $4,564 | $280,545 | 2 | Cinemien | false | false |
| 10 | 6 | Revolutionary Road | $99,991 | -24.2% | 42 | -2 | $2,380 | $529,834 | 3 | Universal Pictures International (UPI) | false | false |
| 11 | 7 | Madagascar: Escape 2 Africa | $89,436 | -29.3% | 108 | -3 | $828 | $8,083,811 | 12 | Universal Pictures International (UPI) | false | false |
| 12 | - | Doubt | $71,035 | - | 33 | - | $2,152 | $73,913 | 1 | Walt Disney Pictures | true | false |
| 13 | 13 | Milk | $52,903 | +1.1% | 21 | - | $2,519 | $222,278 | 3 | A-Film Distribution | false | false |
| 14 | 9 | Seven Pounds | $52,590 | -45.6% | 35 | -6 | $1,502 | $704,113 | 4 | Sony Pictures Releasing | false | false |
| 15 | 10 | The Silent Army | $50,604 | -42.2% | 65 | -15 | $778 | $2,775,642 | 9 | Independent Films | false | false |
| 16 | 11 | High School Musical 3: Senior Year | $44,514 | -36.4% | 79 | -19 | $563 | $2,735,772 | 9 | Walt Disney Pictures | false | false |
| 17 | 15 | Vicky Cristina Barcelona | $39,565 | -1.7% | 24 | +2 | $1,648 | $1,034,367 | 9 | Cinéart | false | false |
| 18 | 14 | Righteous Kill | $22,852 | -48.7% | 13 | -6 | $1,757 | $464,482 | 5 | Moonlight Films | false | false |
| 19 | 12 | Zack and Miri Make a Porno | $20,367 | -64% | 20 | -35 | $1,018 | $250,980 | 3 | Benelux Film Distributors | false | false |
| 20 | - | The Class | $17,218 | - | 18 | - | $956 | $642,726 | 11 | Cinéart | false | false |
| 21 | 22 | Quantum of Solace | $3,172 | -61.3% | 5 | -4 | $634 | $8,891,362 | 14 | Sony Pictures Releasing | false | false |
