| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bedtime Stories | $113,287 | - | 55 | - | $2,059 | $113,287 | 1 | Ster-Kinekor Pictures | true | false |
| 2 | 1 | Bride Wars | $109,003 | -39% | 60 | - | $1,816 | $341,020 | 2 | NuMetro Distribution | false | false |
| 3 | - | Valkyrie | $88,817 | - | 50 | - | $1,776 | $88,817 | 1 | NuMetro Distribution | true | false |
| 4 | 2 | Transporter 3 | $71,127 | -34.2% | 69 | - | $1,030 | $480,166 | 3 | United International Pictures | false | false |
| 5 | 3 | Yes Man | $41,524 | -18.5% | 58 | -2 | $715 | $755,762 | 5 | NuMetro Distribution | false | false |
| 6 | 5 | Mr. Bones 2: Back from the Past | $30,631 | -29.6% | 50 | -18 | $612 | $3,327,527 | 10 | United International Pictures | false | false |
| 7 | 6 | Four Christmases | $27,701 | -35.2% | 39 | -11 | $710 | $409,491 | 4 | NuMetro Distribution | false | false |
| 8 | 4 | Revolutionary Road | $27,641 | -37.2% | 18 | - | $1,535 | $94,115 | 2 | United International Pictures | false | false |
| 9 | 7 | Twilight | $27,279 | -15% | 41 | -4 | $665 | $727,323 | 7 | NuMetro Distribution | false | false |
| 10 | - | The Duchess | $24,217 | - | 12 | - | $2,018 | $24,217 | 1 | Ster-Kinekor Pictures | true | false |
| 11 | 8 | Burn After Reading | $22,589 | -26.5% | 22 | - | $1,026 | $233,134 | 4 | Ster-Kinekor Pictures | false | false |
| 12 | 9 | Bolt | $17,582 | -38.1% | 32 | -12 | $549 | $887,384 | 6 | Ster-Kinekor Pictures | false | false |
| 13 | - | RocknRolla | $17,400 | - | 20 | - | $870 | $17,400 | 1 | NuMetro Distribution | true | false |
| 14 | 11 | Australia | $12,133 | -45.9% | 28 | -15 | $433 | $520,585 | 6 | NuMetro Distribution | false | false |
| 15 | 12 | Saw V | $11,121 | -48.8% | 20 | -10 | $556 | $98,156 | 3 | Ster-Kinekor Pictures | false | false |
| 16 | 10 | Killshot | $10,776 | -60.6% | 25 | - | $431 | $42,753 | 2 | Ster-Kinekor Pictures | false | false |
| 17 | - | Frost/Nixon | $9,243 | - | 10 | - | $924 | $9,243 | 1 | United International Pictures | true | false |
| 18 | 15 | Vicky Cristina Barcelona | $8,955 | -35.7% | 13 | -3 | $688 | $146,672 | 5 | United International Pictures | false | false |
| 19 | 13 | Madagascar: Escape 2 Africa | $8,194 | -52.8% | 21 | -24 | $390 | $2,025,899 | 9 | United International Pictures | false | false |
| 20 | 16 | The Tale of Despereaux | $6,870 | -44.8% | 21 | -9 | $327 | $288,035 | 5 | United International Pictures | false | false |
| 21 | 18 | Igor | $5,485 | -51.4% | 20 | - | $274 | $20,079 | 2 | Ster-Kinekor Pictures | false | false |
| 22 | - | Ghost Town | $5,202 | - | 10 | - | $520 | $5,202 | 1 | United International Pictures | true | false |
| 23 | 14 | The Other End of the Line | $4,507 | -68.1% | 8 | -12 | $563 | $66,558 | 3 | NuMetro Distribution | false | false |
| 24 | 19 | Pride and Glory | $2,958 | -65.2% | 14 | -11 | $211 | $212,571 | 5 | NuMetro Distribution | false | false |
| 25 | 21 | Vaatjie Sien sy Gat | $1,713 | -60.2% | 4 | -6 | $428 | $214,743 | 6 | Ster-Kinekor Pictures | false | false |
| 26 | 26 | Nick and Norah's Infinite Playlist | $152 | -78.7% | 1 | -3 | $152 | $50,433 | 7 | Ster-Kinekor Pictures | false | false |
