| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $649,316 | +48.2% | 75 | +24 | $8,657 | $1,190,872 | 2 | Warner Bros. | false | false |
| 2 | 11 | Twilight | $602,905 | +604.5% | 80 | +62 | $7,536 | $1,648,181 | 12 | Ascot Elite Entertainment Group | false | false |
| 3 | 6 | Bolt | $322,666 | +51.7% | 74 | +20 | $4,360 | $983,917 | 11 | Walt Disney Pictures | false | false |
| 4 | 4 | Slumdog Millionaire | $281,052 | -6.5% | 29 | +2 | $9,691 | $1,264,878 | 5 | Pathé | false | false |
| 5 | 2 | Revolutionary Road | $256,103 | -24.8% | 45 | -8 | $5,691 | $1,651,030 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 3 | Valkyrie | $207,521 | -37.6% | 61 | -11 | $3,401 | $943,364 | 3 | 20th Century Fox International | false | false |
| 7 | - | Hotel for Dogs | $180,918 | - | 44 | - | $4,111 | $180,918 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | - | Bride Wars | $179,118 | - | 32 | - | $5,597 | $179,118 | 1 | 20th Century Fox International | true | false |
| 9 | 5 | Australia | $165,933 | -25.6% | 50 | -12 | $3,318 | $4,932,941 | 7 | 20th Century Fox International | false | false |
| 10 | 7 | Transporter 3 | $127,929 | -31.2% | 12 | -2 | $10,660 | $434,256 | 6 | JMH Distribution | false | false |
| 11 | 9 | Changeling | $97,592 | -32.3% | 34 | -5 | $2,870 | $1,301,200 | 13 | Universal Pictures International (UPI) | false | false |
| 12 | 10 | Madagascar: Escape 2 Africa | $95,452 | -33.4% | 61 | -18 | $1,564 | $10,891,003 | 10 | Universal Pictures International (UPI) | false | false |
| 13 | - | Doubt | $66,628 | - | 9 | - | $7,403 | $67,209 | 2 | Walt Disney Pictures | false | false |
| 14 | 8 | Seven Pounds | $64,712 | -59.4% | 33 | -16 | $1,960 | $1,587,871 | 5 | Sony Pictures Releasing | false | false |
| 15 | 15 | The Class | $64,322 | +10.2% | 9 | +1 | $7,146 | $633,528 | 20 | Filmcoopi | false | false |
| 16 | - | The Spirit | $53,162 | - | 16 | - | $3,322 | $138,789 | 7 | Walt Disney Pictures | false | false |
| 17 | 12 | Yes Man | $47,384 | -41.6% | 13 | - | $3,644 | $327,434 | 5 | Warner Bros. | false | false |
| 18 | 16 | Vicky Cristina Barcelona | $39,310 | -7% | 13 | -5 | $3,023 | $2,435,699 | 18 | Frenetic Films | false | false |
| 19 | - | LOL (Laughing Out Loud) | $39,224 | - | 3 | - | $13,074 | $39,224 | 1 | Pathé | true | false |
| 20 | 14 | Wild Chicks and Life | $36,273 | -42% | 10 | - | $3,627 | $111,756 | 2 | Pathé | false | false |
| 21 | 20 | Welcome to the Sticks | $35,382 | +20.7% | 6 | - | $5,897 | $9,897,101 | 50 | Pathé | false | false |
| 22 | 17 | Buddenbrooks | $35,036 | -3.7% | 8 | -2 | $4,379 | $768,734 | 7 | Warner Bros. | false | false |
| 23 | 21 | Burn After Reading | $12,547 | -37.6% | 9 | -6 | $1,394 | $3,003,717 | 21 | Ascot Elite Entertainment Group | false | false |
| 24 | 25 | Fly Me to the Moon 3D | $3,669 | +15.7% | 1 | - | $3,669 | $88,360 | 15 | N/A | false | false |
| 25 | 24 | Milk | $3,420 | +6% | 1 | -1 | $3,420 | $14,051 | 3 | Ascot Elite Entertainment Group | false | false |
| 26 | 23 | Inkheart | $1,731 | -55.9% | 4 | -4 | $432 | $317,966 | 9 | Warner Bros. | false | false |
