| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Slumdog Millionaire | $177,983 | -41.9% | 17 | -6 | $10,469 | $571,050 | 2 | Gulf Film | false | false |
| 2 | - | The Spirit | $174,117 | - | 20 | - | $8,705 | $174,117 | 1 | N/A | true | false |
| 3 | - | Seven Pounds | $138,503 | - | 19 | - | $7,289 | $138,503 | 1 | N/A | true | false |
| 4 | - | The Tale of Despereaux | $125,437 | - | 20 | - | $6,271 | $125,437 | 1 | N/A | true | false |
| 5 | 1 | Yes Man | $115,228 | -63% | 16 | -4 | $7,201 | $537,948 | 2 | N/A | false | false |
| 6 | 3 | Underworld: Rise of the Lycans | $78,890 | -67.5% | 16 | -3 | $4,930 | $403,246 | 2 | N/A | false | false |
| 7 | 4 | Sorry to Disturb | $78,523 | -57.9% | 20 | - | $3,926 | $341,070 | 2 | N/A | false | false |
| 8 | - | My Mom's New Boyfriend | $75,835 | - | 14 | - | $5,416 | $75,835 | 1 | N/A | true | false |
| 9 | - | Amusement | $45,416 | - | 13 | - | $3,493 | $45,416 | 1 | N/A | true | false |
| 10 | 5 | Valkyrie | $29,250 | -67.9% | 4 | -13 | $7,312 | $551,409 | 3 | N/A | false | false |
| 11 | 7 | Bride Wars | $25,010 | -51% | 4 | -2 | $6,252 | $321,015 | 3 | N/A | false | false |
| 12 | 6 | Revolutionary Road | $15,390 | -73.5% | 5 | -14 | $3,078 | $98,171 | 2 | N/A | false | false |
| 13 | 8 | Bedtime Stories | $7,669 | -66.2% | 2 | - | $3,834 | $586,369 | 6 | N/A | false | false |
| 14 | 11 | Madagascar: Escape 2 Africa | $3,772 | -58.3% | 3 | - | $1,257 | $1,877,512 | 10 | N/A | false | false |
| 15 | 10 | Changeling | $3,364 | -66.4% | 1 | -2 | $3,364 | $272,158 | 4 | N/A | false | false |
| 16 | 15 | Twilight | $2,453 | -37.7% | 1 | -1 | $2,453 | $1,237,891 | 9 | N/A | false | false |
| 17 | 14 | City of Ember | $2,320 | -67.6% | 3 | - | $773 | $207,614 | 4 | N/A | false | false |
| 18 | 13 | Bolt | $1,985 | -73% | 1 | - | $1,985 | $463,007 | 9 | N/A | false | false |
| 19 | 20 | Righteous Kill | $570 | -19.1% | 1 | - | $570 | $328,816 | 7 | N/A | false | false |
| 20 | 9 | Mutant Chronicles | $452 | -96.9% | 1 | -12 | $452 | $179,431 | 3 | N/A | false | false |
| 21 | 12 | Harold & Kumar Escape from Guantanamo Bay | $348 | -95.8% | 1 | -5 | $348 | $128,302 | 3 | N/A | false | false |
