| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bride Wars | $178,562 | - | 60 | - | $2,976 | $178,562 | 1 | NuMetro Distribution | true | false |
| 2 | 1 | Transporter 3 | $108,024 | -44.8% | 69 | - | $1,565 | $367,531 | 2 | United International Pictures | false | false |
| 3 | 3 | Yes Man | $50,929 | -26.6% | 60 | +1 | $848 | $690,996 | 4 | NuMetro Distribution | false | false |
| 4 | - | Revolutionary Road | $43,984 | - | 18 | - | $2,443 | $43,984 | 1 | United International Pictures | true | false |
| 5 | 4 | Mr. Bones 2: Back from the Past | $43,487 | -31.5% | 68 | -11 | $639 | $3,276,382 | 9 | United International Pictures | false | false |
| 6 | 2 | Four Christmases | $42,741 | -44.3% | 50 | - | $854 | $362,343 | 3 | NuMetro Distribution | false | false |
| 7 | 7 | Twilight | $32,085 | -25.1% | 45 | - | $713 | $684,059 | 6 | NuMetro Distribution | false | false |
| 8 | 5 | Burn After Reading | $30,749 | -36.2% | 22 | - | $1,397 | $195,734 | 3 | Ster-Kinekor Pictures | false | false |
| 9 | 6 | Bolt | $28,413 | -38.2% | 44 | -11 | $645 | $861,705 | 5 | Ster-Kinekor Pictures | false | false |
| 10 | - | Killshot | $27,366 | - | 25 | - | $1,094 | $27,366 | 1 | Ster-Kinekor Pictures | true | false |
| 11 | 9 | Australia | $22,424 | -36.1% | 43 | -11 | $521 | $495,500 | 5 | NuMetro Distribution | false | false |
| 12 | 8 | Saw V | $21,707 | -45.4% | 30 | - | $723 | $76,493 | 2 | Ster-Kinekor Pictures | false | false |
| 13 | 10 | Madagascar: Escape 2 Africa | $17,366 | -49.2% | 45 | -20 | $385 | $1,992,922 | 8 | United International Pictures | false | false |
| 14 | 12 | The Other End of the Line | $14,117 | -46.3% | 20 | - | $705 | $50,483 | 2 | NuMetro Distribution | false | false |
| 15 | 14 | Vicky Cristina Barcelona | $13,923 | -31.6% | 16 | - | $870 | $128,498 | 4 | United International Pictures | false | false |
| 16 | 13 | The Tale of Despereaux | $12,455 | -48.8% | 30 | -6 | $415 | $277,255 | 4 | United International Pictures | false | false |
| 17 | 11 | CC2C | $12,389 | -58% | 13 | - | $953 | $49,682 | 2 | NuMetro Distribution | false | false |
| 18 | - | Igor | $11,282 | - | 20 | - | $564 | $11,282 | 1 | Ster-Kinekor Pictures | true | false |
| 19 | 16 | Pride and Glory | $8,500 | -26.9% | 25 | -8 | $340 | $205,156 | 4 | NuMetro Distribution | false | false |
| 20 | 15 | City of Ember | $7,020 | -54% | 17 | -13 | $412 | $80,346 | 3 | NuMetro Distribution | false | false |
| 21 | 18 | Vaatjie Sien sy Gat | $4,303 | -42.8% | 10 | -7 | $430 | $196,552 | 5 | Ster-Kinekor Pictures | false | false |
| 22 | 20 | Make It Happen | $2,965 | -23.1% | 12 | -5 | $247 | $271,101 | 6 | United International Pictures | false | false |
| 23 | 17 | Quantum of Solace | $2,545 | -72% | 6 | -10 | $424 | $1,957,830 | 10 | Ster-Kinekor Pictures | false | false |
| 24 | 19 | The Women | $2,030 | -62% | 7 | -6 | $290 | $375,199 | 8 | Ster-Kinekor Pictures | false | false |
| 25 | 23 | Wild Child | $1,146 | -38.9% | 7 | -3 | $163 | $459,542 | 11 | United International Pictures | false | false |
| 26 | 24 | Nick and Norah's Infinite Playlist | $712 | -51.2% | 4 | - | $178 | $49,921 | 6 | Ster-Kinekor Pictures | false | false |
| 27 | 25 | In Bruges | $157 | -54.5% | 1 | - | $157 | $153,705 | 19 | Ster-Kinekor Pictures | false | false |
