| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transporter 3 | $195,748 | - | 69 | - | $2,836 | $195,748 | 1 | United International Pictures | true | false |
| 2 | 1 | Four Christmases | $76,728 | -47% | 50 | - | $1,534 | $295,048 | 2 | NuMetro Distribution | false | false |
| 3 | 2 | Yes Man | $69,381 | -38.4% | 59 | -1 | $1,175 | $626,317 | 3 | NuMetro Distribution | false | false |
| 4 | 3 | Mr. Bones 2: Back from the Past | $63,485 | -34.5% | 79 | -3 | $803 | $3,295,241 | 8 | United International Pictures | false | false |
| 5 | 6 | Burn After Reading | $48,173 | -24.7% | 22 | - | $2,189 | $148,321 | 2 | Ster-Kinekor Pictures | false | false |
| 6 | 4 | Bolt | $45,942 | -40.7% | 55 | -13 | $835 | $836,339 | 4 | Ster-Kinekor Pictures | false | false |
| 7 | 7 | Twilight | $42,844 | -28.4% | 45 | -1 | $952 | $647,907 | 5 | NuMetro Distribution | false | false |
| 8 | - | Saw V | $39,736 | - | 30 | - | $1,324 | $39,736 | 1 | Ster-Kinekor Pictures | true | false |
| 9 | 8 | Australia | $35,103 | -30.6% | 54 | -3 | $650 | $467,011 | 4 | NuMetro Distribution | false | false |
| 10 | 5 | Madagascar: Escape 2 Africa | $34,208 | -50.3% | 65 | -14 | $526 | $2,013,295 | 7 | United International Pictures | false | false |
| 11 | - | CC2C | $29,506 | - | 13 | - | $2,269 | $29,506 | 1 | NuMetro Distribution | true | false |
| 12 | - | The Other End of the Line | $26,306 | - | 20 | - | $1,315 | $26,306 | 1 | NuMetro Distribution | true | false |
| 13 | 9 | The Tale of Despereaux | $24,319 | -48% | 36 | -13 | $675 | $263,858 | 3 | United International Pictures | false | false |
| 14 | 14 | Vicky Cristina Barcelona | $20,342 | +10.4% | 16 | -1 | $1,271 | $107,469 | 3 | United International Pictures | false | false |
| 15 | 10 | City of Ember | $15,260 | -52.4% | 30 | - | $508 | $68,298 | 2 | NuMetro Distribution | false | false |
| 16 | 11 | Pride and Glory | $11,621 | -62.2% | 33 | -7 | $352 | $183,508 | 3 | NuMetro Distribution | false | false |
| 17 | 12 | Quantum of Solace | $9,105 | -62.5% | 16 | -15 | $569 | $2,003,746 | 9 | Ster-Kinekor Pictures | false | false |
| 18 | 15 | Vaatjie Sien sy Gat | $7,519 | -58% | 17 | -6 | $442 | $194,787 | 4 | Ster-Kinekor Pictures | false | false |
| 19 | 17 | The Women | $5,344 | -33.8% | 13 | -3 | $411 | $370,380 | 7 | Ster-Kinekor Pictures | false | false |
| 20 | 16 | Make It Happen | $3,854 | -67.9% | 17 | -15 | $226 | $275,929 | 5 | United International Pictures | false | false |
| 21 | - | The Counterfeiters | $2,761 | - | 4 | - | $690 | $80,122 | 11 | Ster-Kinekor Pictures | false | false |
| 22 | 20 | Boy A | $2,395 | -7.1% | 3 | - | $798 | $20,882 | 4 | Ster-Kinekor Pictures | false | false |
| 23 | 19 | Wild Child | $1,876 | -57.7% | 10 | -3 | $187 | $469,270 | 10 | United International Pictures | false | false |
| 24 | 22 | Nick and Norah's Infinite Playlist | $1,460 | -33.9% | 4 | -1 | $365 | $48,131 | 5 | Ster-Kinekor Pictures | false | false |
| 25 | - | In Bruges | $345 | - | 1 | - | $345 | $153,420 | 18 | Ster-Kinekor Pictures | false | false |
