| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Marley & Me | $348,255 | - | 40 | - | $8,706 | $348,255 | 1 | N/A | true | false |
| 2 | - | Seven Pounds | $270,081 | - | 35 | - | $7,716 | $270,081 | 1 | N/A | true | false |
| 3 | 1 | Madagascar: Escape 2 Africa | $179,404 | -39.8% | 62 | -9 | $2,893 | $5,234,517 | 6 | N/A | false | false |
| 4 | 2 | Twilight | $163,800 | -30.3% | 51 | -5 | $3,211 | $2,386,474 | 5 | N/A | false | false |
| 5 | 3 | Bolt | $144,803 | -27.1% | 57 | - | $2,540 | $1,999,617 | 5 | N/A | false | false |
| 6 | - | Bangkok Dangerous | $117,592 | - | 24 | - | $4,899 | $133,082 | 1 | N/A | true | false |
| 7 | 5 | The Tale of Despereaux | $60,666 | -53.1% | 34 | -6 | $1,784 | $702,092 | 3 | N/A | false | false |
| 8 | 9 | The Abandoned | $56,130 | -28.7% | 13 | +1 | $4,317 | $192,615 | 2 | N/A | false | false |
| 9 | 4 | Four Christmases | $54,385 | -59.6% | 30 | -5 | $1,812 | $1,182,546 | 4 | N/A | false | false |
| 10 | 6 | Burn After Reading | $54,201 | -57% | 35 | +2 | $1,548 | $313,072 | 2 | N/A | false | false |
| 11 | 10 | The Marsh | $48,769 | -29.9% | 10 | - | $4,876 | $171,078 | 2 | N/A | false | false |
| 12 | - | RocknRolla | $47,879 | - | 25 | - | $1,915 | $47,879 | 1 | N/A | true | false |
| 13 | 7 | The Day the Earth Stood Still | $36,735 | -62.5% | 23 | -13 | $1,597 | $2,315,193 | 6 | N/A | false | false |
| 14 | 12 | A mi me gusta | $33,899 | -30% | 16 | +4 | $2,118 | $504,677 | 6 | N/A | false | false |
| 15 | 11 | Australia | $21,052 | -69.5% | 10 | -21 | $2,105 | $750,436 | 4 | N/A | false | false |
| 16 | 8 | Max Payne | $18,674 | -76.9% | 19 | -18 | $982 | $600,645 | 3 | N/A | false | false |
| 17 | 13 | The Boy in the Striped Pajamas | $14,394 | -37.5% | 9 | - | $1,599 | $266,289 | 9 | N/A | false | false |
| 18 | 15 | Body of Lies | $5,531 | -46.9% | 2 | -7 | $2,765 | $579,599 | 6 | N/A | false | false |
| 19 | 17 | Caramel | $3,885 | -21% | 2 | - | $1,942 | $50,846 | 5 | N/A | false | false |
| 20 | 16 | High School Musical 3: Senior Year | $2,113 | -74.6% | 6 | -12 | $352 | $1,448,347 | 8 | N/A | false | false |
| 21 | 18 | Beverly Hills Chihuahua | $1,875 | -59.4% | 5 | -2 | $375 | $1,431,937 | 10 | N/A | false | false |
| 22 | 19 | Awake | $1,165 | -71.9% | 3 | -1 | $388 | $716,133 | 8 | N/A | false | false |
| 23 | 14 | Quantum of Solace | $488 | -95.6% | 3 | -5 | $162 | $1,155,619 | 7 | N/A | false | false |
| 24 | 21 | Fierro | $9 | -99% | 1 | -1 | $9 | $1,208 | 2 | N/A | false | false |
