| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Yes Man | $167,997 | - | 40 | - | $4,199 | $167,997 | 1 | Warner Bros. | true | false |
| 2 | 2 | Bolt | $113,536 | -22.3% | 38 | -19 | $2,987 | $1,082,206 | 4 | Walt Disney Pictures | false | false |
| 3 | 1 | Twilight | $108,741 | -29.2% | 39 | -11 | $2,788 | $800,305 | 3 | Bazuca Films | false | false |
| 4 | 3 | Beverly Hills Chihuahua | $87,624 | -17.8% | 35 | -3 | $2,503 | $263,817 | 2 | Walt Disney Pictures | false | false |
| 5 | - | Marley & Me | $61,388 | - | 28 | - | $2,192 | $61,388 | 1 | 20th Century Fox International | true | false |
| 6 | 4 | Australia | $60,911 | -39.3% | 39 | -13 | $1,561 | $207,206 | 2 | 20th Century Fox International | false | false |
| 7 | - | The Boy in the Striped Pajamas | $37,746 | - | 8 | - | $4,718 | $37,746 | 1 | Walt Disney Pictures | true | false |
| 8 | 6 | Madagascar: Escape 2 Africa | $27,641 | -48% | 7 | -35 | $3,948 | $1,945,073 | 7 | United International Pictures | false | false |
| 9 | 7 | Burn After Reading | $22,763 | -51.3% | 15 | -5 | $1,517 | $91,106 | 2 | United International Pictures | false | false |
| 10 | 5 | The Day the Earth Stood Still | $18,139 | -66.8% | 18 | -28 | $1,007 | $1,043,249 | 6 | 20th Century Fox International | false | false |
| 11 | - | In Bruges | $17,175 | - | 9 | - | $1,908 | $17,175 | 1 | Bazuca Films | true | false |
| 12 | 8 | El Regalo | $4,077 | -39.7% | 2 | - | $2,038 | $713,663 | 16 | - | false | false |
| 13 | - | Lokas | $2,648 | - | 1 | - | $2,648 | $645,800 | 42 | Andes Films | false | false |
| 14 | 9 | Quantum of Solace | $1,414 | -64.1% | 1 | -2 | $1,414 | $949,223 | 11 | Sony Pictures Releasing | false | false |
| 15 | 12 | Body of Lies | $1,038 | -66.4% | 2 | +1 | $519 | $223,646 | 9 | Warner Bros. | false | false |
| 16 | 11 | Four Christmases | $694 | -79.9% | 1 | -1 | $694 | $89,290 | 5 | Warner Bros. | false | false |
| 17 | - | Muñeca | $226 | - | 1 | - | $226 | $68,205 | 7 | Bazuca Films | false | false |
| 18 | 15 | RocknRolla | $128 | -91.7% | 1 | - | $128 | $45,151 | 4 | Warner Bros. | false | false |
| 19 | - | El diario de Agustín | $24 | - | 1 | - | $24 | $5,675 | 5 | - | false | false |
