| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Yes Man | $380,166 | -35.3% | 60 | -42 | $6,336 | $1,089,906 | 2 | Warner Bros. | false | false |
| 2 | - | De l'autre côté du lit | $267,597 | - | 25 | - | $10,703 | $280,979 | 1 | Belga Films | true | false |
| 3 | 1 | Madagascar: Escape 2 Africa | $223,596 | -65.8% | 109 | -2 | $2,051 | $6,122,472 | 6 | Universal Pictures International (UPI) | false | false |
| 4 | 5 | Twilight | $209,857 | -13.6% | 54 | - | $3,886 | $2,407,708 | 7 | Belga Films | false | false |
| 5 | 3 | Loft | $188,877 | -34.7% | 32 | - | $5,902 | $9,051,462 | 12 | Independent Films | false | false |
| 6 | 4 | Australia | $151,415 | -39.4% | 90 | -12 | $1,682 | $1,483,576 | 4 | 20th Century Fox International | false | false |
| 7 | - | The Duchess | $133,650 | - | 30 | - | $4,455 | $137,135 | 1 | Cinéart | true | false |
| 8 | 8 | Burn After Reading | $98,638 | -31.4% | 33 | -2 | $2,989 | $1,354,709 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | The Day the Earth Stood Still | $93,799 | -49% | 70 | -10 | $1,339 | $1,994,901 | 5 | 20th Century Fox International | false | false |
| 10 | 6 | Bedtime Stories | $84,286 | -64.7% | 45 | -8 | $1,873 | $843,296 | 3 | Walt Disney Pictures | false | false |
| 11 | 9 | Transporter 3 | $80,431 | -41.2% | 28 | - | $2,872 | $1,233,601 | 5 | Belga Films | false | false |
| 12 | 13 | Two Lovers | $57,618 | -33.9% | 14 | - | $4,115 | $358,188 | 3 | Cinéart | false | false |
| 13 | 11 | The Heir Apparent: Largo Winch | $50,933 | -48.7% | 17 | -1 | $2,996 | $522,691 | 4 | Cinéart | false | false |
| 14 | 10 | The Flight Before Christmas | $38,123 | -68.3% | 33 | -1 | $1,155 | $534,202 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 15 | - | Appaloosa | $33,512 | - | 9 | - | $3,723 | $47,551 | 1 | Paradiso Entertainment | true | false |
| 16 | 15 | Trouble at Timpetill | $30,803 | -60.7% | 16 | - | $1,925 | $448,547 | 4 | Alternative Films | false | false |
| 17 | 16 | Saw V | $30,765 | -41.2% | 32 | - | $961 | $642,322 | 4 | Les Films de l'Elysée | false | false |
| 18 | 12 | Piet Piraat en het zwaard van Zilvertand | $28,285 | -67.6% | 32 | - | $883 | $524,670 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 19 | - | Incendiary | $25,480 | - | 12 | - | $2,123 | $25,703 | 1 | Kinepolis Film Distribution (KFD) | true | false |
| 20 | 14 | Four Christmases | $24,019 | -69.7% | 20 | -5 | $1,200 | $392,177 | 3 | Warner Bros. | false | false |
| 21 | 25 | Changeling | $18,882 | -19.2% | 17 | +2 | $1,110 | $1,006,500 | 9 | Universal Pictures International (UPI) | false | false |
| 22 | 22 | Winter in Wartime | $18,439 | -44% | 13 | +1 | $1,418 | $289,231 | 6 | Benelux Film Distributors | false | false |
| 23 | 18 | Quantum of Solace | $17,841 | -57.6% | 9 | -6 | $1,982 | $4,704,110 | 10 | Sony Pictures Releasing | false | false |
| 24 | 24 | Louise hires a contract killer | $16,210 | -38.9% | 9 | -2 | $1,801 | $120,283 | 3 | Les Films de l'Elysée | false | false |
| 25 | 19 | Wild Child | $14,782 | -62.3% | 12 | -4 | $1,231 | $189,906 | 3 | Universal Pictures International (UPI) | false | false |
| 26 | 20 | Anything for Her | $14,710 | -61.7% | 13 | - | $1,131 | $67,725 | 2 | Benelux Film Distributors | false | false |
| 27 | 17 | Blinker en de blixvaten | $14,010 | -67.3% | 31 | -2 | $451 | $252,648 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 28 | 26 | The Visitor | $13,198 | -34.5% | 10 | -1 | $1,319 | $130,596 | 4 | N/A | false | false |
| 29 | 28 | Vicky Cristina Barcelona | $11,508 | -31.9% | 7 | -3 | $1,644 | $1,140,871 | 11 | Cinéart | false | false |
| 30 | 29 | The Silent Army | $11,341 | -29.7% | 8 | -1 | $1,417 | $133,142 | 4 | N/A | false | false |
| 31 | 21 | High School Musical 3: Senior Year | $11,201 | -70.7% | 13 | -4 | $861 | $2,802,965 | 11 | Walt Disney Pictures | false | false |
| 32 | 31 | Pride and Glory | $7,734 | -20% | 3 | - | $2,578 | $198,117 | 6 | Kinepolis Film Distribution (KFD) | false | false |
| 33 | 23 | Christmas in Paris | $6,802 | -75.7% | 13 | -5 | $523 | $211,160 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 34 | - | Factory Girl | $5,806 | - | 8 | - | $725 | $5,806 | 1 | N/A | true | false |
| 35 | 30 | Body of Lies | $5,536 | -50.7% | 3 | -12 | $1,845 | $895,108 | 8 | Warner Bros. | false | false |
| 36 | 27 | Agathe Cléry | $5,087 | -71.7% | 11 | -1 | $462 | $301,850 | 6 | Alternative Films | false | false |
| 37 | 33 | Anubis en het Pad der 7 Zonden | $2,976 | -64.6% | 3 | - | $992 | $1,497,748 | 13 | Kinepolis Film Distribution (KFD) | false | false |
| 38 | 38 | Modern Life | $2,489 | -31.1% | 3 | -1 | $829 | $45,675 | 10 | Benelux Film Distributors | false | false |
| 39 | 37 | Elegy | $1,681 | -54.3% | 7 | - | $240 | $186,860 | 12 | Kinepolis Film Distribution (KFD) | false | false |
| 40 | - | The Beautiful Person | $1,619 | - | 1 | - | $1,619 | $2,475 | 1 | Centre national du cinéma et de l'image animée (CNC) | true | false |
| 41 | 47 | Mamma Mia! | $1,180 | +53% | 2 | -3 | $590 | $3,876,491 | 18 | Universal Pictures International (UPI) | false | false |
| 42 | 40 | Public Enemy | $987 | -37.6% | 5 | - | $197 | $316,996 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 43 | 45 | Home | $704 | -14.9% | 4 | +1 | $176 | $54,703 | 9 | Benelux Film Distributors | false | false |
| 44 | 50 | Hunger | $553 | -15.8% | 4 | +1 | $138 | $36,519 | 9 | Paradiso Entertainment | false | false |
| 45 | 49 | Son of Rambow | $309 | -58.9% | 4 | +1 | $77 | $5,091 | 3 | Universal Pictures International (UPI) | false | false |
| 46 | 41 | A Pain in the Ass | $305 | -77.2% | 2 | -4 | $152 | $76,536 | 5 | Benelux Film Distributors | false | false |
| 47 | 44 | The Wave | $279 | -66.9% | 2 | +1 | $139 | $50,849 | 12 | Paradiso Entertainment | false | false |
| 48 | 48 | Moscow, Belgium | $232 | -69.8% | 1 | -1 | $232 | $1,881,403 | 50 | Kinepolis Film Distribution (KFD) | false | false |
| 49 | 46 | The Edge of Love | $197 | -75.6% | 1 | - | $197 | $15,935 | 7 | Belga Films | false | false |
| 50 | 52 | W. | $53 | +783.3% | 1 | - | $53 | $139,848 | 11 | Paradiso Entertainment | false | false |
