| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Quantum of Solace | $427,005 | - | 79 | - | $5,405 | $427,005 | 1 | N/A | true | false |
| 2 | 1 | High School Musical 3: Senior Year | $285,554 | -42.5% | 60 | -2 | $4,759 | $951,202 | 2 | N/A | false | false |
| 3 | 3 | Awake | $136,785 | -5.4% | 22 | - | $6,217 | $403,134 | 2 | N/A | false | false |
| 4 | 2 | Beverly Hills Chihuahua | $133,015 | -30.5% | 40 | +1 | $3,325 | $1,263,710 | 4 | N/A | false | false |
| 5 | 4 | Death Race | $55,532 | -50.5% | 38 | - | $1,461 | $458,956 | 3 | N/A | false | false |
| 6 | 5 | Mirrors | $46,214 | -39.3% | 20 | -1 | $2,310 | $1,033,711 | 6 | N/A | false | false |
| 7 | 8 | Blindness | $31,996 | -42.2% | 14 | -1 | $2,285 | $127,811 | 2 | N/A | false | false |
| 8 | 7 | Before the Devil Knows You're Dead | $22,607 | -64.9% | 14 | -10 | $1,614 | $136,517 | 2 | N/A | false | false |
| 9 | 6 | Babylon A.D. | $21,068 | -68.7% | 17 | -10 | $1,239 | $693,870 | 4 | N/A | false | false |
| 10 | 9 | The Boy in the Striped Pajamas | $19,328 | -45.6% | 10 | -2 | $1,932 | $141,777 | 3 | N/A | false | false |
| 11 | 10 | Forgetting Sarah Marshall | $11,518 | -65.5% | 8 | -17 | $1,439 | $588,943 | 5 | N/A | false | false |
| 12 | 15 | Journey to the Center of the Earth | $11,339 | -27.4% | 10 | -1 | $1,133 | $2,104,581 | 11 | N/A | false | false |
| 13 | 11 | Space Chimps | $11,265 | -61.3% | 17 | -2 | $662 | $402,247 | 5 | N/A | false | false |
| 14 | 12 | Saw V | $8,810 | -57.5% | 10 | -5 | $881 | $1,411,628 | 7 | N/A | false | false |
| 15 | 14 | The Hitcher | $6,152 | -63% | 5 | -3 | $1,230 | $180,252 | 4 | N/A | false | false |
| 16 | 17 | Lovewrecked | $4,440 | -58.1% | 4 | -4 | $1,110 | $292,430 | 8 | N/A | false | false |
| 17 | 13 | Highlander: The Source | $4,405 | -74.6% | 6 | -8 | $734 | $90,856 | 3 | N/A | false | false |
| 18 | 20 | La Virgen Negra | $3,560 | -16.9% | 5 | +1 | $712 | $248,431 | 7 | N/A | false | false |
| 19 | 16 | Mamma Mia! | $2,679 | -79.1% | 7 | -8 | $382 | $777,863 | 7 | N/A | false | false |
| 20 | 21 | Shortbus | $2,050 | -35.6% | 1 | -1 | $2,050 | $54,857 | 4 | N/A | false | false |
| 21 | 19 | The Forbidden Kingdom | $1,612 | -68.6% | 3 | -5 | $537 | $412,981 | 6 | N/A | false | false |
| 22 | 18 | 3:10 to Yuma | $1,520 | -70.9% | 2 | -1 | $760 | $231,223 | 5 | N/A | false | false |
| 23 | 25 | We Own the Night | $789 | -53.6% | 3 | - | $263 | $136,068 | 6 | N/A | false | false |
| 24 | 22 | Lakeview Terrace | $524 | -80.2% | 2 | -2 | $262 | $255,813 | 5 | N/A | false | false |
