| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Madagascar: Escape 2 Africa | $842,144 | - | 115 | - | $7,322 | $1,656,911 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | Loft | $299,504 | -35.9% | 322 | +280 | $930 | $6,451,797 | 7 | Independent Films | false | false |
| 3 | 2 | Twilight | $234,040 | -33.9% | 54 | +2 | $4,334 | $634,637 | 2 | Belga Films | false | false |
| 4 | 3 | Quantum of Solace | $173,183 | -41% | 96 | -1 | $1,803 | $4,321,044 | 5 | Sony Pictures Releasing | false | false |
| 5 | 4 | Body of Lies | $108,343 | -42.1% | 50 | - | $2,166 | $649,840 | 3 | Warner Bros. | false | false |
| 6 | 6 | Changeling | $83,764 | -34.5% | 33 | - | $2,538 | $713,555 | 4 | Universal Pictures International (UPI) | false | false |
| 7 | - | Agathe Cléry | $83,341 | - | 13 | - | $6,410 | $83,341 | 1 | Alternative Films | true | false |
| 8 | 5 | Max Payne | $82,742 | -50% | 33 | -2 | $2,507 | $272,503 | 2 | 20th Century Fox International | false | false |
| 9 | - | A.R.O.G | $81,072 | - | 5 | - | $16,214 | $81,072 | 1 | Maxximum Film und Kunst GmbH | true | false |
| 10 | - | Pride and Glory | $71,445 | - | 19 | - | $3,760 | $74,020 | 1 | Kinepolis Film Distribution (KFD) | true | false |
| 11 | - | Winter in Wartime | $50,975 | - | 15 | - | $3,398 | $55,477 | 1 | Benelux Film Distributors | true | false |
| 12 | 7 | High School Musical 3: Senior Year | $43,269 | -46.6% | 61 | -3 | $709 | $2,299,668 | 6 | Walt Disney Pictures | false | false |
| 13 | 10 | The Bank Job | $37,102 | -34.3% | 15 | - | $2,473 | $112,575 | 2 | Benelux Film Distributors | false | false |
| 14 | - | Quarantine | $36,284 | - | 13 | - | $2,791 | $83,873 | 1 | Sony Pictures Releasing | true | false |
| 15 | 8 | Public Enemy | $34,282 | -45.6% | 19 | - | $1,804 | $237,406 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 16 | 11 | Vicky Cristina Barcelona | $34,116 | -29.7% | 20 | - | $1,705 | $911,847 | 6 | Cinéart | false | false |
| 17 | 12 | Le vilain | $22,156 | -45.3% | 12 | -1 | $1,846 | $210,443 | 4 | Victory Productions | false | false |
| 18 | 15 | Space Chimps | $20,979 | -22.2% | 43 | -4 | $487 | $1,169,274 | 7 | Belga Films | false | false |
| 19 | 9 | Nights in Rodanthe | $19,151 | -69.2% | 20 | -5 | $957 | $111,966 | 2 | Warner Bros. | false | false |
| 20 | - | Quiet Chaos | $17,505 | - | 10 | - | $1,750 | $25,359 | 1 | Cinéart | true | false |
| 21 | 13 | Journey to the Center of the Earth | $17,060 | -55.7% | 11 | - | $1,550 | $237,490 | 4 | Warner Bros. | false | false |
| 22 | 17 | Musée haut, musée bas | $11,854 | -51.7% | 6 | - | $1,975 | $44,209 | 2 | Cinéart | false | false |
| 23 | 18 | Brideshead Revisited | $11,323 | -42.2% | 11 | - | $1,029 | $37,142 | 2 | Cinéart | false | false |
| 24 | 21 | The Class | $9,461 | -32.8% | 33 | +14 | $286 | $691,159 | 10 | Cinéart | false | false |
| 25 | 16 | Anubis en het Pad der 7 Zonden | $8,999 | -64.5% | 25 | -4 | $359 | $1,294,002 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 26 | 14 | The Ottoman Republic | $8,275 | -71.4% | 5 | -1 | $1,655 | $82,966 | 3 | Maxximum Film und Kunst GmbH | false | false |
| 27 | 22 | Crime Is Our Business | $7,805 | -38.1% | 6 | - | $1,300 | $57,974 | 4 | Cinéart | false | false |
| 28 | 20 | Sinterklaas en het geheim van het grote boek | $7,334 | -52% | 8 | +1 | $916 | $79,019 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 29 | 26 | Rachel Getting Married | $5,845 | -45.1% | 2 | -1 | $2,922 | $18,731 | 2 | Sony Pictures Releasing | false | false |
| 30 | 32 | Seraphine | $5,685 | -28.1% | 6 | - | $947 | $134,335 | 7 | Cinéart | false | false |
| 31 | 23 | Mesrine: Killer Instinct | $5,554 | -54.3% | 12 | -4 | $462 | $521,619 | 7 | A-Film Distribution | false | false |
| 32 | 24 | Nowhere Man | $3,956 | -64.9% | 7 | -1 | $565 | $18,473 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 33 | 19 | RocknRolla | $3,837 | -75.6% | 3 | -7 | $1,279 | $68,340 | 3 | Universal Pictures International (UPI) | false | false |
| 34 | 36 | Elegy | $3,725 | -7.7% | 10 | +2 | $372 | $140,332 | 7 | Kinepolis Film Distribution (KFD) | false | false |
| 35 | 30 | Welcome to the Sticks | $3,718 | -57.6% | 8 | -1 | $464 | $10,627,838 | 41 | Alternative Films | false | false |
| 36 | 41 | Modern Life | $3,296 | +17.5% | 2 | - | $1,648 | $22,954 | 5 | Benelux Film Distributors | false | false |
| 37 | 27 | The Accidental Husband | $3,288 | -68.6% | 3 | -9 | $1,096 | $357,392 | 5 | Belga Films | false | false |
| 38 | - | Coquelicots | $3,023 | - | 5 | - | $604 | $3,931 | 1 | N/A | true | false |
| 39 | 29 | Mamma Mia! | $3,003 | -66.8% | 18 | -7 | $166 | $3,785,891 | 13 | Universal Pictures International (UPI) | false | false |
| 40 | 25 | Baby Blues | $2,440 | -77.6% | 4 | -4 | $610 | $18,602 | 2 | Les Films de l'Elysée | false | false |
| 41 | 31 | Righteous Kill | $2,330 | -71.4% | 6 | -22 | $388 | $580,189 | 6 | Benelux Film Distributors | false | false |
| 42 | 46 | Hunger | $2,183 | +18.9% | 5 | - | $436 | $25,394 | 4 | Paradiso Entertainment | false | false |
| 43 | 42 | The Edge of Love | $2,093 | -22% | 2 | - | $1,046 | $8,403 | 2 | Belga Films | false | false |
| 44 | 33 | Bouquet final | $1,837 | -76% | 8 | -4 | $229 | $101,873 | 4 | Belga Films | false | false |
| 45 | 38 | My Best Friend's Girl | $1,766 | -43.9% | 1 | - | $1,766 | $432,532 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 46 | 35 | WALL·E | $1,759 | -56.5% | 4 | -2 | $439 | $4,278,350 | 19 | Walt Disney Pictures | false | false |
| 47 | 37 | Kung Fu Panda | $1,656 | -53% | 3 | -5 | $552 | $5,827,314 | 22 | Universal Pictures International (UPI) | false | false |
| 48 | 34 | Home | $1,612 | -75.4% | 6 | - | $268 | $43,783 | 4 | Benelux Film Distributors | false | false |
| 49 | 28 | Sex Drive | $1,189 | -87.6% | 6 | -8 | $198 | $427,393 | 6 | Belga Films | false | false |
| 50 | 45 | Death Race | $923 | -52.4% | 1 | - | $923 | $531,678 | 9 | Universal Pictures International (UPI) | false | false |
| 51 | 50 | Happy-Go-Lucky | $900 | -16.7% | 6 | -4 | $150 | $215,330 | 15 | Kinepolis Film Distribution (KFD) | false | false |
| 52 | 56 | Tricks | $865 | +93.9% | 1 | - | $865 | $5,356 | 6 | Benelux Film Distributors | false | false |
| 53 | 54 | A French Gigolo | $672 | -1.3% | 2 | - | $336 | $166,104 | 9 | Benelux Film Distributors | false | false |
| 54 | 49 | Blindness | $411 | -65.1% | 5 | -3 | $82 | $167,646 | 9 | Kinepolis Film Distribution (KFD) | false | false |
| 55 | 52 | Cut Loose | $407 | -49.6% | 4 | +2 | $101 | $606,005 | 12 | Kinepolis Film Distribution (KFD) | false | false |
| 56 | 47 | Moscow, Belgium | $290 | -82.4% | 2 | - | $145 | $1,870,443 | 45 | Kinepolis Film Distribution (KFD) | false | false |
| 57 | 60 | The Zone | $255 | +3.2% | 1 | -1 | $255 | $59,233 | 11 | Paradiso Entertainment | false | false |
| 58 | 44 | W. | $202 | -91.5% | 1 | -2 | $202 | $124,454 | 6 | Paradiso Entertainment | false | false |
| 59 | 61 | The Wave | $54 | +54.3% | 1 | - | $54 | $42,201 | 7 | Paradiso Entertainment | false | false |
