| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Quantum of Solace | $127,213 | -47.2% | 118 | -6 | $1,078 | $912,440 | 3 | Sony Pictures Releasing | false | false |
| 2 | - | Righteous Kill | $125,985 | - | 44 | - | $2,863 | $125,985 | 1 | CDI Films | true | false |
| 3 | 2 | Che: Part One | $95,606 | -43.7% | 50 | +2 | $1,912 | $337,306 | 2 | Alfa Films | false | false |
| 4 | 3 | Saw V | $68,928 | -44% | 62 | +3 | $1,111 | $860,043 | 4 | Walt Disney Pictures | false | false |
| 5 | - | La leyenda | $60,948 | - | 47 | - | $1,296 | $78,833 | 1 | United International Pictures | true | false |
| 6 | - | Max Payne | $49,947 | - | 28 | - | $1,783 | $49,947 | 1 | 20th Century Fox International | true | false |
| 7 | - | Elegy | $47,285 | - | 22 | - | $2,149 | $47,285 | 1 | Distribution Company | true | false |
| 8 | 5 | Beverly Hills Chihuahua | $41,191 | -41.3% | 61 | +1 | $675 | $1,441,602 | 7 | Walt Disney Pictures | false | false |
| 9 | 4 | Burn After Reading | $36,746 | -49.5% | 50 | - | $734 | $785,413 | 5 | United International Pictures | false | false |
| 10 | 8 | The Bank Job | $27,737 | -26.2% | 33 | +1 | $840 | $521,271 | 6 | Alfa Films | false | false |
| 11 | 6 | Flawless | $19,905 | -56.7% | 21 | - | $947 | $162,427 | 3 | Distribution Company | false | false |
| 12 | 7 | My Mom's New Boyfriend | $16,910 | -58.4% | 16 | -1 | $1,056 | $71,136 | 2 | - | false | false |
| 13 | 10 | Black Christmas | $15,608 | -52.8% | 26 | - | $600 | $60,569 | 2 | Distribution Company | false | false |
| 14 | 9 | The Nightmare Before Christmas 2009 3D Release | $14,005 | -61.4% | 3 | - | $4,668 | $177,921 | 4 | Walt Disney Pictures | false | false |
| 15 | 11 | Blindness | $12,310 | -52.2% | 32 | +2 | $384 | $154,798 | 4 | 20th Century Fox International | false | false |
| 16 | 14 | Nights in Rodanthe | $8,762 | -49.1% | 37 | -11 | $236 | $879,637 | 8 | Warner Bros. | false | false |
| 17 | 12 | Mirrors | $6,133 | -67.2% | 31 | -2 | $197 | $606,548 | 8 | 20th Century Fox International | false | false |
| 18 | 15 | Taken | $4,685 | -55.2% | 18 | -9 | $260 | $523,092 | 10 | 20th Century Fox International | false | false |
| 19 | 16 | The Women | $3,219 | -64.8% | 13 | -3 | $247 | $125,784 | 4 | CDI Films | false | false |
| 20 | 18 | Shara | $3,045 | -38.6% | 6 | - | $507 | $38,888 | 4 | Zeta Films | false | false |
| 21 | 20 | Manual of Love 2008 Re-release | $2,404 | -43.5% | 6 | - | $400 | $122,834 | 9 | Notro Films | false | false |
| 22 | 28 | Hellboy II: The Golden Army | $1,856 | -24.9% | 10 | -10 | $185 | $284,705 | 7 | United International Pictures | false | false |
| 23 | 21 | The Heart Is Deceitful Above All Things 2008 Re-release | $1,734 | -45.5% | 3 | +1 | $578 | $6,144 | 2 | 791 Cine | false | false |
| 24 | 19 | You Don't Mess with the Zohan | $1,269 | -71.5% | 7 | -5 | $181 | $721,272 | 10 | Sony Pictures Releasing | false | false |
| 25 | 23 | Disco | $1,158 | -60.8% | 2 | -3 | $579 | $18,787 | 3 | Pachamama Cine | false | false |
| 26 | 22 | Mamma Mia! | $1,143 | -62.4% | 5 | -4 | $228 | $1,460,783 | 14 | United International Pictures | false | false |
| 27 | 29 | The Paranoids | $1,126 | -48% | 4 | +1 | $281 | $38,625 | 5 | Primer Plano Film Group | false | false |
| 28 | 25 | Tropic Thunder | $992 | -63.2% | 6 | -5 | $165 | $1,233,211 | 12 | United International Pictures | false | false |
| 29 | 24 | In Bruges | $931 | -67% | 5 | -7 | $186 | $253,839 | 8 | Distribution Company | false | false |
| 30 | 26 | The Camera Obscura 2008 Re-release | $842 | -67.8% | 4 | -3 | $210 | $63,490 | 6 | Distribution Company | false | false |
| 31 | 17 | Appaloosa | $840 | -87.9% | 8 | -18 | $105 | $319,838 | 7 | Distribution Company | false | false |
| 32 | 27 | Harold & Kumar Escape from Guantanamo Bay | $442 | -82.5% | 5 | -5 | $88 | $25,806 | 5 | Distribution Company | false | false |
| 33 | 31 | A Boyfriend for My Wife | $423 | -74.9% | 5 | -4 | $84 | $5,654,899 | 15 | Walt Disney Pictures | false | false |
| 34 | 38 | Incómodos | $411 | -19.4% | 3 | +1 | $137 | $13,711 | 4 | Primer Plano Film Group | false | false |
| 35 | 32 | Tinker Bell | $384 | -75.4% | 12 | -7 | $32 | $788,437 | 11 | Walt Disney Pictures | false | false |
| 36 | - | Luz de invierno | $301 | - | 1 | - | $301 | $861 | 2 | N/A | false | false |
| 37 | 33 | Don't Look Down | $268 | -80.3% | 1 | -3 | $268 | $16,311 | 4 | Primer Plano Film Group | false | false |
| 38 | 40 | The Magic Flute | $253 | -21.9% | 2 | - | $126 | $23,813 | 5 | Distribution Company | false | false |
| 39 | 37 | Reasons for Not Falling in Love | $253 | -53.2% | 1 | - | $253 | $541,276 | 12 | Distribution Company | false | false |
| 40 | 30 | Lakeview Terrace | $230 | -86.9% | 2 | -7 | $115 | $103,566 | 6 | Sony Pictures Releasing | false | false |
| 41 | 39 | Four Minutes | $210 | -40.2% | 1 | -1 | $210 | $159,565 | 13 | Alfa Films | false | false |
| 42 | 50 | Kill Them All | $156 | +194.3% | 1 | -10 | $156 | $2,285 | 3 | Primer Plano Film Group | false | false |
| 43 | 36 | My Brother is an Only Child | $99 | -83% | 2 | -4 | $49 | $224,946 | 10 | Alfa Films | false | false |
| 44 | 45 | La próxima estación | $99 | -41.1% | 1 | -2 | $99 | $117,476 | 12 | Primer Plano Film Group | false | false |
| 45 | 35 | REC | $93 | -91.5% | 3 | -2 | $31 | $225,119 | 11 | CDI Films | false | false |
| 46 | 41 | Days of Darkness | $62 | -80.5% | 1 | -1 | $62 | $14,445 | 6 | Alfa Films | false | false |
| 47 | 44 | Behind the Sun, More Sky | $54 | -71% | 1 | - | $54 | $1,184 | 3 | N/A | false | false |
| 48 | 34 | Fast Food Nation | $53 | -96% | 1 | -10 | $53 | $42,322 | 5 | Impacto Cine | false | false |
| 49 | 47 | Conversations with My Gardener | $6 | -94.2% | 1 | - | $6 | $221,688 | 31 | Alfa Films | false | false |
