| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Sex and the City | $397,024 | -38.3% | 89 | -14 | $4,460 | $2,748,507 | 3 | Warner Bros. | false | false |
| 2 | 2 | Indiana Jones and the Kingdom of the Crystal Skull | $351,030 | -41% | 73 | -57 | $4,808 | $4,981,319 | 4 | Universal Pictures International (UPI) | false | false |
| 3 | - | The Happening | $230,199 | - | 48 | - | $4,795 | $241,230 | 1 | 20th Century Fox International | true | false |
| 4 | 3 | 21 | $165,941 | -18% | 33 | - | $5,028 | $398,603 | 2 | Walt Disney Pictures | false | false |
| 5 | - | Forgetting Sarah Marshall | $135,091 | - | 30 | - | $4,503 | $143,886 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 4 | What Happens in Vegas | $46,373 | -63.1% | 20 | -26 | $2,318 | $2,069,809 | 6 | 20th Century Fox International | false | false |
| 7 | - | The Nanny Diaries | $34,313 | - | 9 | - | $3,812 | $37,031 | 1 | Ascot Elite Entertainment Group | true | false |
| 8 | 6 | The Wave | $31,642 | -29.3% | 21 | -2 | $1,506 | $789,611 | 7 | Rialto Distribution | false | false |
| 9 | 7 | The Game Plan | $28,961 | -17.7% | 20 | -2 | $1,448 | $346,035 | 7 | Walt Disney Pictures | false | false |
| 10 | 5 | Made of Honor | $27,115 | -45.5% | 23 | -9 | $1,178 | $683,395 | 5 | Walt Disney Pictures | false | false |
| 11 | 11 | Once | $13,527 | -23.7% | 8 | - | $1,690 | $460,796 | 10 | Ascot Elite Entertainment Group | false | false |
| 12 | 12 | Iron Man | $3,819 | -78.3% | 8 | -5 | $477 | $1,354,067 | 7 | Universal Pictures International (UPI) | false | false |
| 13 | 22 | The Other Boleyn Girl | $2,934 | -13.5% | 6 | +1 | $489 | $899,862 | 15 | Universal Pictures International (UPI) | false | false |
| 14 | 23 | No Country for Old Men | $1,328 | -54.2% | 2 | -1 | $664 | $2,208,762 | 21 | Universal Pictures International (UPI) | false | false |
| 15 | 24 | Superhero Movie | $1,255 | -51.8% | 1 | - | $1,255 | $26,294 | 5 | Ascot Elite Entertainment Group | false | false |
| 16 | 25 | Step Up 2: The Streets | $101 | -60.7% | 1 | -1 | $101 | $3,351,591 | 14 | Universal Pictures International (UPI) | false | false |
