| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Sex and the City | $148,206 | - | 15 | - | $9,880 | $148,206 | 1 | Alexandra Films | true | false |
| 2 | 1 | Indiana Jones and the Kingdom of the Crystal Skull | $70,290 | -45.6% | 19 | - | $3,699 | $516,317 | 3 | Prooptiki | false | false |
| 3 | 3 | What Happens in Vegas | $13,891 | -34% | 7 | - | $1,984 | $150,811 | 4 | Alexandra Films | false | false |
| 4 | 2 | 88 Minutes | $12,917 | -58.3% | 5 | - | $2,583 | $53,538 | 2 | Alexandra Films | false | false |
| 5 | 4 | Horton Hears a Who! | $7,105 | -34.7% | 9 | - | $789 | $166,647 | 7 | Alexandra Films | false | false |
| 6 | 5 | Love in the Time of Cholera | $4,387 | -54% | 4 | - | $1,096 | $17,309 | 2 | Prooptiki | false | false |
| 7 | 6 | 21 | $3,571 | -17.7% | 9 | - | $396 | $124,301 | 5 | Alexandra Films | false | false |
| 8 | 7 | Iron Man | $2,826 | -28.1% | 9 | - | $314 | $152,125 | 6 | Prooptiki | false | false |
| 9 | 8 | Fool's Gold | $2,006 | -26.5% | 4 | -4 | $501 | $136,930 | 6 | Alexandra Films | false | false |
| 10 | 10 | Speed Racer | $1,887 | -18.9% | 6 | - | $314 | $15,606 | 4 | Alexandra Films | false | false |
| 11 | 9 | Surviving with Wolves | $965 | -61.8% | 4 | - | $241 | $5,304 | 2 | Sunny Films | false | false |
| 12 | 11 | 99 Francs | $843 | -23.8% | 3 | - | $281 | $11,405 | 5 | Big Bang Media | false | false |
| 13 | 19 | The Eye | $431 | +172.8% | 5 | +2 | $86 | $40,167 | 7 | Alexandra Films | false | false |
| 14 | 17 | Forgetting Sarah Marshall | $387 | +117.4% | 4 | +2 | $96 | $42,500 | 7 | Prooptiki | false | false |
| 15 | 12 | The Spiderwick Chronicles | $293 | -42.9% | 1 | -2 | $293 | $73,566 | 10 | Prooptiki | false | false |
| 16 | 15 | Definitely, Maybe | $167 | -29.8% | 2 | - | $83 | $19,332 | 9 | Prooptiki | false | false |
| 17 | - | In the Name of the King: A Dungeon Siege Tale | $137 | - | 2 | - | $68 | $105,574 | 12 | - | false | false |
| 18 | 14 | The Bucket List | $131 | -64% | 3 | - | $43 | $102,946 | 9 | Alexandra Films | false | false |
| 19 | 22 | The Mist | $127 | +139.6% | 3 | +2 | $42 | $26,350 | 10 | Sunny Films | false | false |
| 20 | 13 | Street Kings | $42 | -90.6% | 2 | -1 | $21 | $128,092 | 8 | Alexandra Films | false | false |
| 21 | 16 | The Game Plan | $40 | -78.6% | 2 | -1 | $20 | $83,789 | 12 | Sunny Films | false | false |
| 22 | 21 | There Will Be Blood | $19 | -71.6% | 1 | - | $19 | $24,498 | 11 | Sunny Films | false | false |
| 23 | 27 | The Mosquito Problem and Other Stories | $18 | +63.6% | 2 | - | $9 | $2,864 | 13 | Sunny Films | false | false |
| 24 | - | Elizabeth: The Golden Age | $14 | - | 1 | - | $14 | $69,202 | 28 | Prooptiki | false | false |
| 25 | 26 | Georgi and the Butterflies | $10 | -28.6% | 1 | - | $10 | $7,727 | 165 | Sunny Films | false | false |
