| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Indiana Jones and the Kingdom of the Crystal Skull | $1,592,342 | - | 133 | - | $11,972 | $1,608,509 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | What Happens in Vegas | $511,094 | -28.1% | 93 | - | $5,495 | $2,085,304 | 3 | Warner Bros. | false | false |
| 3 | 2 | Iron Man | $138,891 | -47.5% | 75 | - | $1,851 | $1,738,041 | 4 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | Dunya & Desie | $90,260 | -36.5% | 75 | -5 | $1,203 | $1,889,007 | 6 | Independent Films | false | false |
| 5 | 4 | Taken | $79,866 | -32.6% | 35 | - | $2,281 | $625,303 | 4 | Independent Films | false | false |
| 6 | - | Over Her Dead Body | $65,154 | - | 20 | - | $3,257 | $99,250 | 1 | RCV Film Distribution | true | false |
| 7 | 6 | Into the Wild | $64,521 | -30.7% | 23 | - | $2,805 | $589,655 | 5 | A-Film Distribution | false | false |
| 8 | 5 | Fool's Gold | $52,840 | -48.7% | 39 | - | $1,354 | $720,388 | 4 | Warner Bros. | false | false |
| 9 | 7 | Happy-Go-Lucky | $51,294 | -29.2% | 21 | - | $2,442 | $151,231 | 2 | RCV Film Distribution | false | false |
| 10 | 10 | Morrison krijgt een zusje | $49,036 | -16.8% | 85 | - | $576 | $474,332 | 5 | Warner Bros. | false | false |
| 11 | 9 | Winx Club: The Secret of the Lost Kingdom | $35,236 | -40.2% | 107 | -2 | $329 | $585,671 | 6 | Independent Films | false | false |
| 12 | 14 | Horton Hears a Who! | $32,786 | -17% | 74 | -15 | $443 | $1,912,195 | 10 | Warner Bros. | false | false |
| 13 | 8 | Be Kind Rewind | $29,600 | -55.1% | 16 | - | $1,850 | $128,969 | 2 | A-Film Distribution | false | false |
| 14 | - | The Orphanage | $27,725 | - | 14 | - | $1,980 | $58,932 | 1 | A-Film Distribution | true | false |
| 15 | 18 | Dragon Hunters | $20,581 | -14.4% | 54 | -7 | $381 | $186,070 | 5 | Independent Films | false | false |
| 16 | 11 | Speed Racer | $20,578 | -57.5% | 83 | -5 | $247 | $152,146 | 3 | Warner Bros. | false | false |
| 17 | - | Elite Squad | $17,361 | - | 15 | - | $1,157 | $33,207 | 1 | Benelux Film Distributors | true | false |
| 18 | 15 | The Bucket List | $17,189 | -55.8% | 23 | -11 | $747 | $1,320,635 | 9 | Warner Bros. | false | false |
| 19 | 12 | Summer Heat | $16,366 | -66.1% | 44 | -35 | $371 | $3,283,980 | 10 | Independent Films | false | false |
| 20 | 19 | Paris | $13,990 | -33.7% | 10 | - | $1,399 | $45,159 | 2 | Cinéart | false | false |
| 21 | 17 | Vantage Point | $8,864 | -72.9% | 13 | -22 | $681 | $1,079,396 | 7 | Sony Pictures Releasing | false | false |
