| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Indiana Jones and the Kingdom of the Crystal Skull | $88,536 | - | 5 | - | $17,707 | $88,536 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | What Happens in Vegas | $20,855 | -39.7% | 3 | - | $6,951 | $149,535 | 3 | Universal Pictures International (UPI) | false | false |
| 3 | 3 | 21 | $5,321 | -32% | 3 | - | $1,773 | $174,891 | 6 | Universal Pictures International (UPI) | false | false |
| 4 | 2 | Iron Man | $4,287 | -61.7% | 3 | - | $1,429 | $103,593 | 4 | Universal Pictures International (UPI) | false | false |
| 5 | 6 | Fool's Gold | $3,766 | -23.5% | 2 | - | $1,883 | $121,938 | 7 | Universal Pictures International (UPI) | false | false |
| 6 | 9 | The Orphanage | $3,042 | -13.8% | 1 | - | $3,042 | $31,719 | 5 | ACME | false | false |
| 7 | 10 | Deception | $2,545 | -14.4% | 1 | - | $2,545 | $24,167 | 4 | ACME | false | false |
| 8 | 8 | Female Agents | $2,530 | -30.6% | 1 | - | $2,530 | $13,866 | 3 | ACME | false | false |
| 9 | 7 | Leatherheads | $2,519 | -36.6% | 1 | - | $2,519 | $48,440 | 5 | Universal Pictures International (UPI) | false | false |
| 10 | 4 | Speed Racer | $2,475 | -58.4% | 3 | - | $825 | $10,930 | 2 | Universal Pictures International (UPI) | false | false |
| 11 | 5 | Balls of Fury | $2,435 | -52.6% | 1 | - | $2,435 | $10,545 | 2 | Garsu Pasaulio Irasai | false | false |
| 12 | 13 | Horton Hears a Who! | $1,185 | -29.3% | 7 | - | $169 | $224,070 | 10 | Universal Pictures International (UPI) | false | false |
| 13 | 11 | Drillbit Taylor | $1,092 | -58.3% | 1 | - | $1,092 | $76,888 | 8 | Universal Pictures International (UPI) | false | false |
