| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Iron Man | $2,392,351 | -24.8% | 365 | - | $6,554 | $14,199,391 | 3 | Paramount Pictures International | false | false |
| 2 | 2 | What Happens in Vegas | $1,932,037 | -16% | 335 | - | $5,767 | $5,108,151 | 2 | 20th Century Fox International | false | false |
| 3 | - | 21 | $1,473,409 | - | 191 | - | $7,714 | $1,473,409 | 1 | Sony Pictures Releasing | true | false |
| 4 | 3 | Made of Honor | $599,816 | -34.2% | 252 | -3 | $2,380 | $3,882,547 | 3 | Sony Pictures Releasing | false | false |
| 5 | - | Shutter | $407,174 | - | 72 | - | $5,655 | $407,174 | 1 | 20th Century Fox International | true | false |
| 6 | - | Then She Found Me | $309,450 | - | 54 | - | $5,730 | $385,493 | 1 | Hopscotch Films | true | false |
| 7 | 4 | Forgetting Sarah Marshall | $231,528 | -30.9% | 148 | -64 | $1,564 | $6,107,382 | 5 | Universal Pictures International (UPI) | false | false |
| 8 | 5 | The Painted Veil | $225,075 | -18.8% | 54 | +1 | $4,168 | $1,923,466 | 4 | Paramount Pictures International | false | false |
| 9 | 6 | Miss Pettigrew Lives for a Day | $171,577 | -30.7% | 71 | - | $2,416 | $616,306 | 2 | Roadshow Films | false | false |
| 10 | 7 | The Counterfeiters | $162,310 | +6.6% | 19 | +2 | $8,542 | $388,225 | 2 | Madman Entertainment | false | false |
| 11 | 10 | Nim's Island | $110,128 | +0.6% | 136 | -11 | $809 | $5,656,670 | 7 | Universal Pictures International (UPI) | false | false |
| 12 | 11 | Gone Baby Gone | $76,248 | -20.3% | 36 | -3 | $2,118 | $1,114,143 | 5 | Walt Disney Pictures | false | false |
| 13 | - | A Secret | $70,813 | - | 18 | - | $3,934 | $145,524 | 1 | Icon Film Distribution | true | false |
| 14 | 14 | Lars and the Real Girl | $66,389 | -9% | 39 | +1 | $1,702 | $1,092,881 | 7 | Rialto Distribution | false | false |
| 15 | 8 | Deception | $65,928 | -47.3% | 55 | -30 | $1,198 | $1,369,173 | 4 | 20th Century Fox International | false | false |
| 16 | 16 | U2 3D | $63,720 | +2% | 9 | -4 | $7,080 | $1,190,909 | 6 | Roadshow Films | false | false |
| 17 | 9 | Street Kings | $62,231 | -49.6% | 65 | -51 | $957 | $3,810,865 | 5 | 20th Century Fox International | false | false |
| 18 | 17 | The Edge of Heaven | $50,174 | -19.3% | 16 | +2 | $3,135 | $429,433 | 4 | Sharmill Films | false | false |
| 19 | 18 | The Spiderwick Chronicles | $48,232 | -18.5% | 78 | -39 | $618 | $7,503,131 | 7 | Paramount Pictures International | false | false |
| 20 | - | Sharkwater | $46,866 | - | 41 | - | $1,143 | $57,779 | 1 | Walt Disney Pictures | true | false |
| 21 | 12 | Smother | $29,727 | -63.7% | 124 | -11 | $239 | $152,385 | 2 | Hoyts Distribution | false | false |
| 22 | 20 | The Black Balloon | $27,581 | -17.8% | 39 | -10 | $707 | $2,053,597 | 11 | Icon Film Distribution | false | false |
| 23 | 21 | Horton Hears a Who! | $27,218 | -16.6% | 50 | -33 | $544 | $11,158,676 | 9 | 20th Century Fox International | false | false |
| 24 | 24 | Before the Devil Knows You're Dead | $25,009 | -3.8% | 29 | -5 | $862 | $1,437,759 | 9 | Hopscotch Films | false | false |
| 25 | 23 | Prom Night | $23,075 | -20.9% | 33 | -4 | $699 | $2,566,794 | 6 | Sony Pictures Releasing | false | false |
| 26 | 22 | Molière | $22,574 | -30.3% | 15 | - | $1,504 | $288,085 | 3 | Hopscotch Films | false | false |
| 27 | 27 | Step Up 2: The Streets | $19,030 | -15.1% | 31 | -15 | $613 | $8,646,325 | 9 | Universal Pictures International (UPI) | false | false |
| 28 | 26 | Paris | $12,061 | -49.7% | 15 | -13 | $804 | $671,999 | 6 | Icon Film Distribution | false | false |
| 29 | 25 | Bhoothnath | $11,311 | -55.9% | 8 | - | $1,413 | $45,690 | 2 | Eros Worldwide | false | false |
| 30 | 28 | The Other Boleyn Girl | $10,650 | -46% | 32 | -6 | $332 | $3,899,816 | 10 | Universal Pictures International (UPI) | false | false |
| 31 | 30 | Superhero Movie | $9,328 | -48.7% | 20 | -20 | $466 | $3,272,513 | 6 | Roadshow Films | false | false |
| 32 | 42 | Black Water | $7,409 | +119.7% | 7 | +5 | $1,058 | $45,997 | 4 | All Interactive Distribution | false | false |
| 33 | 29 | Cactus | $6,545 | -64.4% | 28 | -10 | $233 | $142,530 | 3 | Hoyts Distribution | false | false |
| 34 | 34 | Brick Lane | $5,240 | -8.3% | 13 | +1 | $403 | $602,657 | 9 | Madman Entertainment | false | false |
| 35 | 37 | Be Kind Rewind | $5,235 | +2.9% | 8 | -7 | $654 | $909,739 | 9 | Roadshow Films | false | false |
| 36 | 35 | Closing the Ring | $4,971 | -11.2% | 11 | -1 | $451 | $371,528 | 11 | Hopscotch Films | false | false |
| 37 | 33 | 120 | $4,750 | -27.7% | 2 | - | $2,375 | $48,996 | 6 | N/A | false | false |
| 38 | 39 | Never Back Down | $3,931 | -2.4% | 9 | -6 | $436 | $3,032,582 | 8 | Roadshow Films | false | false |
| 39 | 32 | Semi-Pro | $3,353 | -49% | 8 | -10 | $419 | $3,883,845 | 7 | Roadshow Films | false | false |
| 40 | 36 | The Bucket List | $2,687 | -47.4% | 10 | -12 | $268 | $7,507,485 | 13 | Warner Bros. | false | false |
| 41 | 48 | 10,000 BC | $2,287 | +531.8% | 9 | +3 | $254 | $6,253,110 | 11 | Warner Bros. | false | false |
| 42 | 47 | Run Fatboy Run | $1,965 | +359.1% | 6 | -2 | $327 | $3,193,961 | 11 | Roadshow Films | false | false |
| 43 | 44 | In the Shadow of the Moon | $1,867 | +27.6% | 6 | - | $311 | $370,173 | 11 | Madman Entertainment | false | false |
| 44 | - | Tashan | $1,319 | - | 4 | - | $329 | $222,019 | 4 | MG Distribution | false | false |
| 45 | 40 | The Ten Commandments | $1,314 | -62.3% | 5 | -7 | $262 | $56,355 | 4 | - | false | false |
| 46 | 45 | U Me Aur Hum | $1,037 | -9.6% | 2 | -1 | $518 | $135,607 | 6 | Eros Worldwide | false | false |
| 47 | 31 | Captivity | $894 | -93.3% | 2 | -40 | $447 | $21,561 | 2 | Roadshow Films | false | false |
