| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Iron Man | $3,181,164 | -45% | 365 | - | $8,715 | $10,781,355 | 2 | Paramount Pictures International | false | false |
| 2 | - | What Happens in Vegas | $2,298,783 | - | 335 | - | $6,862 | $2,331,097 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Made of Honor | $911,877 | -36.6% | 255 | -1 | $3,575 | $2,948,538 | 2 | Sony Pictures Releasing | false | false |
| 4 | 3 | Forgetting Sarah Marshall | $334,820 | -49.2% | 212 | -36 | $1,579 | $5,665,337 | 4 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | The Painted Veil | $277,017 | -12.9% | 53 | +4 | $5,226 | $1,567,404 | 3 | Paramount Pictures International | false | false |
| 6 | - | Miss Pettigrew Lives for a Day | $247,659 | - | 71 | - | $3,488 | $332,538 | 1 | Roadshow Films | true | false |
| 7 | - | The Counterfeiters | $152,240 | - | 17 | - | $8,955 | $167,046 | 1 | Madman Entertainment | true | false |
| 8 | 6 | Deception | $125,071 | -49.8% | 85 | -27 | $1,471 | $1,234,442 | 3 | 20th Century Fox International | false | false |
| 9 | 5 | Street Kings | $123,458 | -58.1% | 116 | -100 | $1,064 | $3,644,812 | 4 | 20th Century Fox International | false | false |
| 10 | 7 | Nim's Island | $109,442 | -38.6% | 147 | -38 | $744 | $5,456,340 | 6 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Gone Baby Gone | $95,630 | -32.1% | 39 | -1 | $2,452 | $988,969 | 4 | Walt Disney Pictures | false | false |
| 12 | - | Smother | $81,942 | - | 135 | - | $606 | $82,254 | 1 | Hoyts Distribution | true | false |
| 13 | 8 | Untraceable | $74,216 | -55.2% | 85 | -37 | $873 | $943,007 | 3 | Universal Pictures International (UPI) | false | false |
| 14 | 12 | Lars and the Real Girl | $72,970 | -20.9% | 38 | +4 | $1,920 | $983,788 | 6 | Rialto Distribution | false | false |
| 15 | - | Then She Found Me | $64,753 | - | 53 | - | $1,221 | $70,830 | - | Hopscotch Films | - | false |
| 16 | 15 | U2 3D | $62,447 | -27.1% | 13 | -4 | $4,803 | $1,090,890 | 5 | Roadshow Films | false | false |
| 17 | 17 | The Edge of Heaven | $62,175 | -21.2% | 14 | +1 | $4,441 | $353,587 | 3 | Sharmill Films | false | false |
| 18 | 10 | The Spiderwick Chronicles | $59,216 | -54.2% | 117 | -83 | $506 | $7,343,465 | 6 | Paramount Pictures International | false | false |
| 19 | 11 | Smart People | $36,799 | -67.5% | 87 | -45 | $422 | $669,238 | 3 | Icon Film Distribution | false | false |
| 20 | 20 | The Black Balloon | $33,554 | -25.9% | 49 | -4 | $684 | $1,983,166 | 10 | Icon Film Distribution | false | false |
| 21 | 16 | Horton Hears a Who! | $32,651 | -61% | 83 | -101 | $393 | $10,984,035 | 8 | 20th Century Fox International | false | false |
| 22 | 24 | Molière | $32,368 | -15.2% | 15 | -20 | $2,157 | $247,900 | 2 | Hopscotch Films | false | false |
| 23 | 13 | Prom Night | $29,156 | -68.2% | 37 | -46 | $788 | $2,516,287 | 5 | Sony Pictures Releasing | false | false |
| 24 | 23 | Before the Devil Knows You're Dead | $25,984 | -37.8% | 34 | -2 | $764 | $1,384,041 | 8 | Hopscotch Films | false | false |
| 25 | - | Bhoothnath | $25,672 | - | 8 | - | $3,209 | $25,672 | 1 | Eros Worldwide | true | false |
| 26 | 19 | Paris | $23,982 | -52.3% | 28 | -2 | $856 | $639,724 | 5 | Icon Film Distribution | false | false |
| 27 | 21 | Step Up 2: The Streets | $22,425 | -49.5% | 46 | -26 | $487 | $8,511,657 | 8 | Universal Pictures International (UPI) | false | false |
| 28 | 26 | The Other Boleyn Girl | $19,721 | -39.2% | 38 | -25 | $518 | $3,832,815 | 9 | Universal Pictures International (UPI) | false | false |
| 29 | 22 | Cactus | $18,385 | -57% | 38 | -2 | $483 | $118,019 | 2 | Hoyts Distribution | false | false |
| 30 | 14 | Superhero Movie | $18,174 | -79.4% | 40 | -89 | $454 | $3,214,859 | 5 | Roadshow Films | false | false |
| 31 | - | Captivity | $13,379 | - | 42 | - | $318 | $13,379 | 1 | Roadshow Films | true | false |
| 32 | 25 | Semi-Pro | $6,573 | -81.7% | 18 | -53 | $365 | $3,828,578 | 6 | Roadshow Films | false | false |
| 33 | - | 120 | $6,573 | - | 2 | - | $3,286 | $39,424 | 5 | N/A | false | false |
| 34 | 32 | Brick Lane | $5,713 | -15% | 12 | -3 | $476 | $586,404 | 8 | Madman Entertainment | false | false |
| 35 | 33 | Closing the Ring | $5,597 | -4.6% | 12 | -10 | $466 | $358,071 | 10 | Hopscotch Films | false | false |
| 36 | 28 | The Bucket List | $5,107 | -53.9% | 22 | +11 | $232 | $7,403,440 | 12 | Warner Bros. | false | false |
| 37 | 30 | Be Kind Rewind | $5,085 | -46.4% | 15 | +8 | $339 | $889,291 | 8 | Roadshow Films | false | false |
| 38 | 36 | Two Days in Paris | $4,556 | +30.3% | 4 | +2 | $1,139 | $1,724,376 | 20 | Hopscotch Films | false | false |
| 39 | 27 | Never Back Down | $4,026 | -68.2% | 15 | -37 | $268 | $2,988,504 | 7 | Roadshow Films | false | false |
| 40 | - | The Ten Commandments | $3,486 | - | 12 | - | $290 | $54,023 | 3 | - | false | false |
| 41 | 29 | St. Trinian's | $3,393 | -66.1% | 11 | -12 | $308 | $2,508,342 | 7 | Sony Pictures Releasing | false | false |
| 42 | - | Black Water | $3,373 | - | 2 | - | $1,686 | $34,775 | 3 | All Interactive Distribution | false | false |
| 43 | - | The Secret of the Grain | $2,101 | - | 1 | - | $2,101 | $360,950 | 8 | Palace Films | false | false |
| 44 | 38 | In the Shadow of the Moon | $1,463 | -34.6% | 6 | - | $243 | $362,462 | 10 | Madman Entertainment | false | false |
| 45 | - | U Me Aur Hum | $1,147 | - | 3 | - | $382 | $132,343 | 5 | Eros Worldwide | false | false |
| 46 | - | Broken Sun | $488 | - | 1 | - | $488 | $4,799 | 3 | JackaFilms | false | false |
| 47 | 37 | Run Fatboy Run | $428 | -84.2% | 8 | -1 | $53 | $3,150,278 | 10 | Roadshow Films | false | false |
| 48 | 41 | 10,000 BC | $362 | -74% | 6 | -3 | $60 | $6,170,045 | 10 | Warner Bros. | false | false |
