| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Horton Hears a Who! | $108,784 | -26.1% | 83 | -3 | $1,310 | $742,975 | 3 | NuMetro Distribution | false | false |
| 2 | 2 | The Game Plan | $94,786 | -21.4% | 55 | - | $1,723 | $1,032,516 | 4 | Ster-Kinekor Pictures | false | false |
| 3 | 4 | Step Up 2: The Streets | $86,348 | -22.7% | 52 | - | $1,660 | $1,206,751 | 5 | NuMetro Distribution | false | false |
| 4 | - | Bakgat! | $79,763 | - | 41 | - | $1,945 | $79,763 | 1 | Ster-Kinekor Pictures | true | false |
| 5 | 3 | Vantage Point | $65,252 | -43.2% | 45 | - | $1,450 | $244,739 | 2 | United International Pictures | false | false |
| 6 | - | Rambo | $64,656 | - | 44 | - | $1,469 | $64,656 | 1 | NuMetro Distribution | true | false |
| 7 | 7 | Fool's Gold | $46,233 | -24.7% | 49 | -6 | $943 | $885,125 | 6 | NuMetro Distribution | false | false |
| 8 | 6 | The Nanny Diaries | $44,798 | -27.7% | 36 | -4 | $1,244 | $309,992 | 3 | Ster-Kinekor Pictures | false | false |
| 9 | - | I Could Never Be Your Woman | $42,670 | - | 20 | - | $2,133 | $42,670 | 1 | NuMetro Distribution | true | false |
| 10 | 5 | 10,000 BC | $41,179 | -37.3% | 46 | -9 | $895 | $650,794 | 4 | NuMetro Distribution | false | false |
| 11 | - | U Me Aur Hum | $28,033 | - | 7 | - | $4,004 | $34,060 | 1 | NuMetro Distribution | true | false |
| 12 | 8 | Why Did I Get Married? | $24,865 | -31.2% | 22 | -3 | $1,130 | $562,515 | 7 | Ster-Kinekor Pictures | false | false |
| 13 | 9 | Juno | $19,970 | -40.9% | 24 | -8 | $832 | $389,224 | 5 | NuMetro Distribution | false | false |
| 14 | - | Starter for 10 | $15,231 | - | 10 | - | $1,523 | $15,231 | 1 | Ster-Kinekor Pictures | true | false |
| 15 | 10 | The Spiderwick Chronicles | $15,083 | -55.2% | 20 | -29 | $754 | $330,533 | 4 | United International Pictures | false | false |
| 16 | 16 | The Kite Runner | $9,440 | -8.9% | 8 | - | $1,180 | $252,262 | 9 | United International Pictures | false | false |
| 17 | 14 | No Country for Old Men | $7,819 | -32.9% | 11 | - | $710 | $194,774 | 7 | United International Pictures | false | false |
| 18 | 13 | Scoop | $7,701 | -37.7% | 10 | - | $770 | $31,849 | 2 | Ster-Kinekor Pictures | false | false |
| 19 | - | The Diving Bell and the Butterfly | $5,272 | - | 3 | - | $1,757 | $46,984 | 4 | Ster-Kinekor Pictures | false | false |
| 20 | 21 | Atonement | $4,173 | -35.2% | 8 | -2 | $521 | $382,349 | 11 | United International Pictures | false | false |
| 21 | 20 | The Water Horse | $3,755 | -41.8% | 9 | -5 | $417 | $259,919 | 6 | United International Pictures | false | false |
| 22 | 22 | Charlie Wilson's War | $1,268 | -58% | 4 | -1 | $317 | $153,637 | 6 | United International Pictures | false | false |
| 23 | 23 | Love in the Time of Cholera | $329 | -84.7% | 2 | -4 | $164 | $68,406 | 5 | United International Pictures | false | false |
| 24 | 25 | Good Luck Chuck | $157 | -71.1% | 1 | -3 | $157 | $398,763 | 12 | United International Pictures | false | false |
