| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 10,000 BC | $309,515 | - | 34 | - | $9,103 | $309,515 | 1 | Warner Bros. | true | false |
| 2 | 1 | American Gangster | $47,619 | -40.9% | 32 | - | $1,488 | $164,756 | 2 | United International Pictures | false | false |
| 3 | 2 | The Water Horse | $44,970 | -39% | 26 | - | $1,729 | $548,765 | 5 | Sony Pictures Releasing | false | false |
| 4 | 4 | One Missed Call | $44,897 | -31% | 19 | -1 | $2,363 | $144,776 | 2 | Warner Bros. | false | false |
| 5 | 3 | The Game Plan | $38,057 | -42.6% | 21 | - | $1,812 | $947,584 | 8 | Walt Disney Pictures | false | false |
| 6 | 5 | No Country for Old Men | $37,433 | -36.8% | 10 | -1 | $3,743 | $266,685 | 4 | United International Pictures | false | false |
| 7 | 9 | The Bucket List | $29,199 | -20.1% | 15 | +1 | $1,946 | $447,992 | 6 | Warner Bros. | false | false |
| 8 | 8 | P.S. I Love You | $28,716 | -25.3% | 14 | -4 | $2,051 | $234,480 | 4 | Bazuca Films | false | false |
| 9 | 7 | Juno | $26,975 | -32.3% | 11 | -4 | $2,452 | $156,227 | 3 | Bazuca Films | false | false |
| 10 | 11 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $25,569 | -14.3% | 1 | - | $25,569 | $68,156 | 2 | Walt Disney Pictures | false | false |
| 11 | 13 | Atonement | $23,976 | -17.5% | 12 | +2 | $1,998 | $204,441 | 4 | United International Pictures | false | false |
| 12 | 10 | There Will Be Blood | $22,083 | -37.7% | 13 | -1 | $1,698 | $145,106 | 3 | Walt Disney Pictures | false | false |
| 13 | 6 | Sweeney Todd: The Demon Barber of Fleet Street | $20,022 | -52.9% | 17 | -1 | $1,177 | $454,575 | 5 | Warner Bros. | false | false |
| 14 | - | 3:10 to Yuma | $13,776 | - | 18 | - | $765 | $13,776 | 1 | Bazuca Films | true | false |
| 15 | 15 | Noah's Ark | $12,007 | -46.4% | 14 | -2 | $857 | $87,467 | 3 | Walt Disney Pictures | false | false |
| 16 | 14 | The Hitcher | $8,729 | -62.9% | 11 | -3 | $793 | $43,286 | 2 | Bazuca Films | false | false |
| 17 | - | The Kite Runner | $6,620 | - | 5 | - | $1,324 | $6,620 | 1 | United International Pictures | true | false |
| 18 | 12 | Cloverfield | $6,338 | -78.4% | 15 | -13 | $422 | $401,900 | 5 | United International Pictures | false | false |
| 19 | 18 | I Am Legend | $4,520 | -35.9% | 10 | -11 | $452 | $1,292,597 | 8 | Warner Bros. | false | false |
| 20 | 16 | 27 Dresses | $4,026 | -58.2% | 7 | -5 | $575 | $191,242 | 5 | 20th Century Fox International | false | false |
| 21 | 17 | Good Luck Chuck | $3,564 | -61.6% | 6 | -3 | $594 | $97,433 | 4 | Sony Pictures Releasing | false | false |
| 22 | 21 | Alvin and the Chipmunks | $1,781 | -48.6% | 6 | -5 | $296 | $863,199 | 12 | 20th Century Fox International | false | false |
| 23 | 19 | Enchanted | $1,488 | -59% | 6 | -1 | $248 | $1,425,339 | 13 | Walt Disney Pictures | false | false |
| 24 | 23 | National Treasure: Book of Secrets | $1,249 | -52.6% | 1 | -2 | $1,249 | $1,032,609 | 11 | Walt Disney Pictures | false | false |
| 25 | 22 | Love in the Time of Cholera | $1,104 | -67% | 3 | -2 | $368 | $366,229 | 8 | 20th Century Fox International | false | false |
| 26 | 24 | Hannibal Rising | $1,016 | -27.1% | 3 | -1 | $338 | $81,862 | 6 | United International Pictures | false | false |
| 27 | 20 | Aliens vs. Predator: Requiem | $593 | -82.9% | 5 | -1 | $118 | $426,416 | 7 | 20th Century Fox International | false | false |
| 28 | 26 | Bridge to Terabithia | $538 | -40.6% | 3 | - | $179 | $62,603 | 10 | United International Pictures | false | false |
| 29 | 32 | Gone Baby Gone | $245 | -25.8% | 1 | -1 | $245 | $30,438 | 7 | Walt Disney Pictures | false | false |
| 30 | 33 | The Mudboy | $22 | -86.6% | 1 | -1 | $22 | $218 | 2 | Walt Disney Pictures | false | false |
