| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Bucket List | $352,779 | - | 65 | - | $5,427 | $353,564 | 1 | Warner Bros. | true | false |
| 2 | - | Cloverfield | $224,135 | - | 40 | - | $5,603 | $224,135 | 1 | United International Pictures | true | false |
| 3 | - | The Water Horse | $173,462 | - | 38 | - | $4,564 | $173,462 | 1 | Sony Pictures Releasing | true | false |
| 4 | 1 | Explosive Brigade: Pirate Mission | $166,504 | -12% | 87 | +2 | $1,913 | $443,724 | 2 | Argentina Sono Film S.A.C.I. | false | false |
| 5 | - | Atonement | $153,773 | - | 38 | - | $4,046 | $153,773 | 1 | United International Pictures | true | false |
| 6 | 2 | National Treasure: Book of Secrets | $127,758 | -28.9% | 82 | +1 | $1,558 | $1,487,699 | 4 | Walt Disney Pictures | false | false |
| 7 | - | 27 Dresses | $115,220 | - | 50 | - | $2,304 | $115,220 | 1 | 20th Century Fox International | true | false |
| 8 | 4 | Enchanted | $114,486 | -16.3% | 108 | +2 | $1,060 | $2,636,056 | 6 | Walt Disney Pictures | false | false |
| 9 | 5 | An American Haunting | $98,102 | -22.1% | 35 | -3 | $2,802 | $276,729 | 2 | Distribution Company | false | false |
| 10 | 3 | Charlie Wilson's War | $95,472 | -43.7% | 42 | -3 | $2,273 | $661,990 | 3 | United International Pictures | false | false |
| 11 | 6 | I Am Legend | $55,819 | -37.8% | 72 | -19 | $775 | $2,021,969 | 7 | Warner Bros. | false | false |
| 12 | 10 | Alvin and the Chipmunks | $45,787 | -1% | 53 | -10 | $863 | $713,920 | 6 | 20th Century Fox International | false | false |
| 13 | 7 | Love in the Time of Cholera | $38,339 | -35.7% | 28 | -4 | $1,369 | $391,948 | 4 | 20th Century Fox International | false | false |
| 14 | 8 | Aliens vs. Predator: Requiem | $35,354 | -29.8% | 35 | -4 | $1,010 | $613,072 | 5 | 20th Century Fox International | false | false |
| 15 | 11 | American Gangster | $24,944 | -35.4% | 24 | -20 | $1,039 | $741,636 | 6 | United International Pictures | false | false |
| 16 | 14 | The Heartbreak Kid | $13,438 | -20.2% | 19 | -9 | $707 | $884,359 | 14 | United International Pictures | false | false |
| 17 | 9 | 1408 | $12,916 | -72.4% | 14 | -23 | $922 | $205,760 | 3 | United International Pictures | false | false |
| 18 | 12 | Hitman | $11,316 | -60.5% | 16 | -10 | $707 | $139,988 | 3 | 20th Century Fox International | false | false |
| 19 | 19 | Gone Baby Gone | $10,246 | +3% | 13 | -1 | $788 | $399,788 | 12 | Walt Disney Pictures | false | false |
| 20 | 28 | Beowulf | $7,553 | +709.5% | 2 | -6 | $3,776 | $858,415 | 12 | Warner Bros. | false | false |
| 21 | 13 | I Do: How to Get Married and Stay Single | $6,240 | -65.4% | 7 | - | $891 | $61,803 | 3 | Alfa Films | false | false |
| 22 | - | Possible Lives | $5,558 | - | 5 | - | $1,111 | $5,558 | 1 | Primer Plano Film Group | true | false |
| 23 | 16 | The Cave of the Yellow Dog 2008 Re-release | $4,946 | -55.5% | 4 | - | $1,236 | $21,126 | 2 | IFA | false | false |
| 24 | 18 | Sleuth | $3,925 | -60.6% | 10 | -1 | $392 | $145,515 | 5 | Sony Pictures Releasing | false | false |
| 25 | 21 | My Best Friend | $2,434 | -68.8% | 5 | -7 | $486 | $120,570 | 6 | Alfa Films | false | false |
| 26 | 15 | The Golden Compass | $2,280 | -81.5% | 12 | -30 | $190 | $1,385,273 | 9 | Distribution Company | false | false |
| 27 | 22 | Giants of Valdes | $1,845 | -64.4% | 5 | -5 | $369 | $78,872 | 4 | Primer Plano Film Group | false | false |
| 28 | 20 | I Could Never Be Your Woman | $1,623 | -82.1% | 4 | -10 | $405 | $292,796 | 6 | CDI Films | false | false |
| 29 | 25 | Bee Movie | $1,333 | -46.2% | 7 | -7 | $190 | $1,466,351 | 10 | United International Pictures | false | false |
| 30 | 24 | 4 Months, 3 Weeks and 2 Days | $1,281 | -59.3% | 2 | -3 | $640 | $201,614 | 10 | Pachamama Cine | false | false |
| 31 | 29 | Café Lumière 2007 Re-release | $1,016 | +12.9% | 2 | - | $508 | $49,660 | 9 | 791 Cine | false | false |
| 32 | - | Shortbus | $821 | - | 1 | - | $821 | $30,712 | 15 | Distribution Company | false | false |
| 33 | 23 | Goya's Ghosts | $804 | -75.7% | 2 | -2 | $402 | $14,176 | 3 | Alfa Films | false | false |
| 34 | 27 | The Assassination of Jesse James by the Coward Robert Ford | $569 | -66.5% | 4 | -8 | $142 | $153,033 | 11 | Warner Bros. | false | false |
| 35 | 34 | After the Wedding | $325 | -23% | 2 | -1 | $162 | $106,138 | 12 | Alfa Films | false | false |
| 36 | - | Rendition | $311 | - | 1 | - | $311 | $420,070 | 15 | Distribution Company | false | false |
| 37 | 26 | Bordertown | $256 | -89.4% | 2 | -5 | $128 | $58,779 | 4 | Distribution Company | false | false |
| 38 | 52 | Encarnacion | $168 | +380% | 2 | -2 | $84 | $40,696 | 18 | Distribution Company | false | false |
| 39 | 17 | Miss Potter | $135 | -98.7% | 1 | -5 | $135 | $14,923 | 2 | United International Pictures | false | false |
| 40 | 47 | Underdog | $120 | +69% | 3 | -1 | $40 | $850,408 | 19 | Walt Disney Pictures | false | false |
| 41 | - | Suspiros del corazón | $120 | - | 1 | - | $120 | $6,763 | 5 | Primer Plano Film Group | false | false |
| 42 | - | Estrellas | $87 | - | 1 | - | $87 | $14,426 | 9 | Primer Plano Film Group | false | false |
| 43 | 49 | Black Book | $68 | +47.8% | 1 | - | $68 | $469,117 | 25 | Pachamama Cine | false | false |
| 44 | 42 | Lights in the Dusk | $51 | -62.8% | 1 | - | $51 | $51,519 | 20 | Alfa Films | false | false |
| 45 | - | Quiéreme | $34 | - | 1 | - | $34 | $62,172 | 13 | Alfa Films | false | false |
| 46 | 53 | Saw IV | $33 | +3.1% | 1 | -3 | $33 | $1,013,075 | 15 | Walt Disney Pictures | false | false |
| 47 | - | At Five in the Afternoon | $23 | - | 1 | - | $23 | $15,911 | 11 | 791 Cine | false | false |
| 48 | 50 | Vitus | $11 | -72.5% | 1 | - | $11 | $48,522 | 13 | CDI Films | false | false |
