| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Explosive Brigade: Pirate Mission | $189,243 | - | 85 | - | $2,226 | $189,243 | 1 | Argentina Sono Film S.A.C.I. | true | false |
| 2 | 1 | National Treasure: Book of Secrets | $179,778 | -37.6% | 81 | +10 | $2,219 | $1,268,981 | 3 | Walt Disney Pictures | false | false |
| 3 | 2 | Charlie Wilson's War | $169,531 | -31.2% | 45 | +5 | $3,767 | $509,168 | 2 | United International Pictures | false | false |
| 4 | 3 | Enchanted | $136,702 | -41% | 106 | +19 | $1,289 | $2,436,301 | 5 | Walt Disney Pictures | false | false |
| 5 | - | An American Haunting | $125,986 | - | 38 | - | $3,315 | $125,986 | 1 | Distribution Company | true | false |
| 6 | 4 | I Am Legend | $89,754 | -43.9% | 91 | +12 | $986 | $1,921,468 | 6 | Warner Bros. | false | false |
| 7 | 7 | Love in the Time of Cholera | $59,631 | -14% | 32 | +2 | $1,863 | $321,570 | 3 | 20th Century Fox International | false | false |
| 8 | 5 | Aliens vs. Predator: Requiem | $50,335 | -42.2% | 39 | +3 | $1,290 | $549,804 | 4 | 20th Century Fox International | false | false |
| 9 | 6 | 1408 | $46,827 | -44.5% | 37 | +5 | $1,265 | $172,819 | 2 | United International Pictures | false | false |
| 10 | 8 | Alvin and the Chipmunks | $46,268 | -32.9% | 63 | +9 | $734 | $639,842 | 5 | 20th Century Fox International | false | false |
| 11 | 9 | American Gangster | $38,636 | -35.7% | 44 | -8 | $878 | $700,063 | 5 | United International Pictures | false | false |
| 12 | 10 | Hitman | $28,649 | -47.6% | 26 | +1 | $1,101 | $115,156 | 2 | 20th Century Fox International | false | false |
| 13 | 13 | I Do: How to Get Married and Stay Single | $18,010 | -19.4% | 7 | - | $2,572 | $49,402 | 2 | Alfa Films | false | false |
| 14 | 11 | The Heartbreak Kid | $16,839 | -45.8% | 28 | - | $601 | $872,979 | 13 | United International Pictures | false | false |
| 15 | 12 | The Golden Compass | $12,297 | -55.8% | 42 | -6 | $292 | $1,375,421 | 8 | Distribution Company | false | false |
| 16 | - | The Cave of the Yellow Dog 2008 Re-release | $11,109 | - | 4 | - | $2,777 | $11,109 | 1 | IFA | true | false |
| 17 | - | Miss Potter | $10,676 | - | 6 | - | $1,779 | $10,676 | 1 | United International Pictures | true | false |
| 18 | 16 | Sleuth | $9,959 | -36.6% | 11 | +1 | $905 | $137,206 | 4 | Sony Pictures Releasing | false | false |
| 19 | 15 | Gone Baby Gone | $9,952 | -47.9% | 14 | - | $710 | $385,533 | 11 | Walt Disney Pictures | false | false |
| 20 | 14 | I Could Never Be Your Woman | $9,079 | -53.8% | 14 | -4 | $648 | $287,764 | 5 | CDI Films | false | false |
| 21 | 19 | My Best Friend | $7,790 | +1% | 12 | +5 | $649 | $114,644 | 5 | Alfa Films | false | false |
| 22 | 17 | Giants of Valdes | $5,184 | -60.1% | 10 | -6 | $518 | $74,088 | 3 | Primer Plano Film Group | false | false |
| 23 | 22 | Goya's Ghosts | $3,315 | -40.1% | 4 | - | $828 | $11,798 | 2 | Alfa Films | false | false |
| 24 | 20 | 4 Months, 3 Weeks and 2 Days | $3,144 | -54.7% | 5 | -7 | $628 | $198,857 | 9 | Pachamama Cine | false | false |
| 25 | 21 | Bee Movie | $2,476 | -56.9% | 14 | -7 | $176 | $1,463,091 | 9 | United International Pictures | false | false |
| 26 | 18 | Bordertown | $2,415 | -78.9% | 7 | -15 | $345 | $58,189 | 3 | Distribution Company | false | false |
| 27 | 24 | The Assassination of Jesse James by the Coward Robert Ford | $1,697 | -28.7% | 12 | +4 | $141 | $151,590 | 10 | Warner Bros. | false | false |
| 28 | 23 | Beowulf | $933 | -62.9% | 8 | -4 | $116 | $703,896 | 11 | Warner Bros. | false | false |
| 29 | 25 | Café Lumière 2007 Re-release | $900 | -54.3% | 2 | - | $450 | $47,364 | 8 | 791 Cine | false | false |
| 30 | 29 | Lions for Lambs | $867 | -46.7% | 8 | +2 | $108 | $506,256 | 12 | 20th Century Fox International | false | false |
| 31 | - | The Bucket List | $786 | - | 1 | - | $786 | $786 | - | Warner Bros. | - | false |
| 32 | 27 | Bridge to Terabithia | $495 | -72.2% | 5 | -2 | $99 | $93,273 | 4 | United International Pictures | false | false |
| 33 | 33 | Retribution | $451 | -57.2% | 1 | -2 | $451 | $115,072 | 8 | Pachamama Cine | false | false |
| 34 | 34 | After the Wedding | $422 | -19.8% | 3 | +1 | $140 | $105,732 | 11 | Alfa Films | false | false |
| 35 | 32 | The Flock | $270 | -75.1% | 3 | -3 | $90 | $187,073 | 9 | CDI Films | false | false |
| 36 | 40 | Hechos, No Palabras | $259 | +27.6% | 1 | - | $259 | $2,749 | 4 | Primer Plano Film Group | false | false |
| 37 | 38 | Days of Glory | $253 | -25.4% | 2 | - | $126 | $18,890 | 5 | Alfa Films | false | false |
| 38 | 28 | The Hitcher | $215 | -87.2% | 1 | -4 | $215 | $138,291 | 9 | Distribution Company | false | false |
| 39 | 41 | ¿De quién es el portaligas? | $202 | +26.2% | 1 | -1 | $202 | $86,948 | 20 | Primer Plano Film Group | false | false |
| 40 | 54 | Fierro | $153 | +84.3% | 4 | +1 | $38 | $155,289 | 13 | Primer Plano Film Group | false | false |
| 41 | 49 | The Other | $148 | +51% | 2 | +1 | $74 | $118,075 | 39 | Distribution Company | false | false |
| 42 | 47 | Lights in the Dusk | $137 | +10.5% | 1 | - | $137 | $51,616 | 19 | Alfa Films | false | false |
| 43 | 45 | Who Says It's Easy? | $106 | -17.8% | 1 | -1 | $106 | $1,265,601 | 52 | Primer Plano Film Group | false | false |
| 44 | 48 | A Stray Girlfriend | $99 | -13.2% | 1 | -1 | $99 | $48,453 | 35 | Primer Plano Film Group | false | false |
| 45 | 26 | August Rush | $84 | -95.6% | 1 | -4 | $84 | $69,551 | 4 | Distribution Company | false | false |
| 46 | 53 | The Bow | $72 | -19.1% | 3 | +2 | $24 | $931,554 | 54 | Alfa Films | false | false |
| 47 | 36 | Underdog | $71 | -83.4% | 4 | -1 | $17 | $850,139 | 18 | Walt Disney Pictures | false | false |
| 48 | 64 | Música nocturna | $62 | +93.8% | 4 | +3 | $15 | $25,650 | 12 | Primer Plano Film Group | false | false |
| 49 | 57 | Black Book | $46 | -17.9% | 1 | - | $46 | $471,098 | 24 | Pachamama Cine | false | false |
| 50 | 60 | Vitus | $40 | -11.1% | 1 | - | $40 | $48,465 | 12 | CDI Films | false | false |
| 51 | 42 | City in Heat | $37 | -73.6% | 1 | -2 | $37 | $32,697 | 46 | Alfa Films | false | false |
| 52 | 56 | Encarnacion | $35 | -51.4% | 4 | +2 | $8 | $40,443 | 17 | Distribution Company | false | false |
| 53 | 39 | Saw IV | $32 | -90.1% | 4 | +2 | $8 | $1,012,948 | 14 | Walt Disney Pictures | false | false |
| 54 | 30 | Superbad | $23 | -98.4% | 1 | -9 | $23 | $396,122 | 11 | Sony Pictures Releasing | false | false |
| 55 | 66 | Hacer patria | $11 | -47.6% | 1 | - | $11 | $9,149 | 26 | Distribution Company | false | false |
