| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | National Treasure: Book of Secrets | $163,932 | - | 42 | - | $3,903 | $224,710 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Enchanted | $141,733 | +50.9% | 37 | +5 | $3,830 | $498,513 | 3 | Walt Disney Pictures | false | false |
| 3 | 2 | The Golden Compass | $116,091 | +30.2% | 50 | +11 | $2,321 | $497,097 | 3 | Warner Bros. | false | false |
| 4 | 3 | Alvin and the Chipmunks | $108,449 | +35.6% | 35 | +3 | $3,098 | $235,659 | 2 | 20th Century Fox International | false | false |
| 5 | 8 | The Heartbreak Kid | $95,405 | +651.6% | 28 | - | $3,407 | $212,881 | 2 | United International Pictures | false | false |
| 6 | 4 | Bee Movie | $75,814 | +34.1% | 57 | +15 | $1,330 | $564,780 | 4 | United International Pictures | false | false |
| 7 | - | 1408 | $50,635 | - | 14 | - | $3,616 | $64,977 | 1 | United International Pictures | true | false |
| 8 | - | Pulentos, la película | $45,610 | - | 38 | - | $1,200 | $52,219 | 1 | Bazuca Films | true | false |
| 9 | 5 | Saw IV | $27,060 | +18.9% | 18 | -8 | $1,503 | $235,944 | 4 | Walt Disney Pictures | false | false |
| 10 | - | The Assassination of Jesse James by the Coward Robert Ford | $20,145 | - | 10 | - | $2,014 | $26,377 | 1 | Warner Bros. | true | false |
| 11 | 7 | Michael Clayton | $15,694 | +16.1% | 7 | -1 | $2,242 | $108,506 | 4 | Bazuca Films | false | false |
| 12 | 6 | Beowulf | $15,565 | -30% | 1 | -24 | $15,565 | $593,505 | 6 | Warner Bros. | false | false |
| 13 | 9 | Che Kopete: La película | $5,459 | -14.5% | 10 | -7 | $545 | $901,514 | 7 | - | false | false |
| 14 | 11 | Knocked Up | $3,374 | -15.9% | 1 | -2 | $3,374 | $136,193 | 7 | United International Pictures | false | false |
| 15 | 10 | Resident Evil: Extinction | $2,995 | -27.5% | 5 | -5 | $599 | $405,001 | 9 | Sony Pictures Releasing | false | false |
| 16 | 13 | I Now Pronounce You Chuck & Larry | $1,665 | -0.1% | 4 | -2 | $416 | $112,667 | 6 | United International Pictures | false | false |
| 17 | - | Orchestra Seats | $722 | - | 1 | - | $722 | $70,887 | 8 | Transeuropa | false | false |
| 18 | 15 | Underdog | $644 | -30.2% | 3 | -6 | $214 | $495,026 | 10 | Walt Disney Pictures | false | false |
| 19 | 17 | Next | $325 | -49% | 1 | - | $325 | $116,813 | 8 | United International Pictures | false | false |
| 20 | 18 | Premonition | $163 | -51.9% | 1 | - | $163 | $275,246 | 12 | Bazuca Films | false | false |
