| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Golden Compass | $370,262 | -32.9% | 87 | -21 | $4,255 | $2,010,979 | 3 | Warner Bros. | false | false |
| 2 | 6 | Enchanted | $299,874 | +325.3% | 96 | +73 | $3,123 | $719,238 | 4 | Walt Disney Pictures | false | false |
| 3 | - | I Am Legend | $237,360 | - | 27 | - | $8,791 | $267,788 | 1 | Warner Bros. | true | false |
| 4 | 2 | Bee Movie | $203,610 | -46.1% | 78 | -12 | $2,610 | $732,732 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | - | Elizabeth: The Golden Age | $190,502 | - | 36 | - | $5,291 | $257,361 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | - | Alvin and the Chipmunks | $130,244 | - | 42 | - | $3,101 | $137,521 | 1 | 20th Century Fox International | true | false |
| 7 | 3 | Hitman | $116,298 | -32.4% | 24 | -5 | $4,845 | $328,935 | 2 | 20th Century Fox International | false | false |
| 8 | - | Rabbit Without Ears | $106,997 | - | 19 | - | $5,631 | $106,997 | 1 | Warner Bros. | true | false |
| 9 | 15 | Natale in crociera | $97,029 | +247.1% | 14 | +11 | $6,930 | $134,895 | 2 | - | false | false |
| 10 | 7 | The Band's Visit | $82,914 | +20.4% | 18 | +7 | $4,606 | $302,909 | 3 | Xenix Filmdistribution | false | false |
| 11 | 5 | Why Men Don't Listen and Women Can't Read Maps | $82,658 | -27.8% | 22 | - | $3,757 | $396,046 | 3 | Rialto Distribution | false | false |
| 12 | 4 | American Gangster | $64,446 | -44.4% | 25 | -12 | $2,577 | $2,051,851 | 6 | Universal Pictures International (UPI) | false | false |
| 13 | - | A Beautiful Wife | $45,256 | - | 9 | - | $5,028 | $45,256 | 1 | - | true | false |
| 14 | 8 | Ratatouille | $42,578 | -35.9% | 19 | -14 | $2,240 | $8,948,049 | 21 | Walt Disney Pictures | false | false |
| 15 | 13 | Gone Baby Gone | $39,152 | +21.1% | 10 | +1 | $3,915 | $210,819 | 4 | Walt Disney Pictures | false | false |
| 16 | 10 | The Fox and the Child | $31,630 | -6.9% | 12 | +3 | $2,635 | $84,731 | 2 | Frenetic Films | false | false |
| 17 | - | Animals in Love | $31,445 | - | 40 | - | $786 | $42,098 | 1 | JMH Distribution | true | false |
| 18 | 16 | Earth | $28,236 | +13% | 18 | -4 | $1,568 | $1,133,034 | 11 | Frenetic Films | false | false |
| 19 | 11 | Atonement | $17,601 | -46.5% | 8 | -5 | $2,200 | $682,177 | 7 | Universal Pictures International (UPI) | false | false |
| 20 | 18 | The Secret of the Grain | $14,956 | -24.3% | 3 | - | $4,985 | $40,974 | 2 | Pathé | false | false |
