| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: At World's End | $219,554 | -36.4% | 98 | -3 | $2,240 | $1,422,174 | 3 | Buena Vista International | false | false |
| 2 | 2 | Next | $101,476 | -28% | 59 | - | $1,719 | $308,785 | 2 | NuMetro Distribution | false | false |
| 3 | 3 | Spider-Man 3 | $77,693 | -27.9% | 83 | -13 | $936 | $2,336,763 | 6 | Sony Pictures Releasing | false | false |
| 4 | - | Alpha Dog | $44,512 | - | 30 | - | $1,483 | $44,512 | 1 | NuMetro Distribution | true | false |
| 5 | 4 | Fracture | $36,515 | -28.4% | 45 | - | $811 | $491,913 | 5 | NuMetro Distribution | false | false |
| 6 | - | The Reaping | $35,297 | - | 25 | - | $1,411 | $35,297 | 1 | Warner Bros. | true | false |
| 7 | 5 | Employee of the Month | $22,867 | -40.4% | 24 | -11 | $952 | $277,397 | 5 | Ster-Kinekor Pictures | false | false |
| 8 | 7 | I Think I Love My Wife | $20,153 | -25% | 12 | - | $1,679 | $62,942 | 2 | 20th Century Fox International | false | false |
| 9 | 6 | Blades of Glory | $19,039 | -35.7% | 27 | -6 | $705 | $261,104 | 5 | United International Pictures | false | false |
| 10 | 8 | Akeelah and the Bee | $17,816 | -17.1% | 20 | - | $890 | $49,040 | 2 | Ster-Kinekor Pictures | false | false |
| 11 | 11 | As It Is in Heaven | $14,741 | +6% | 2 | -5 | $7,370 | $131,574 | 7 | Ster-Kinekor Pictures | false | false |
| 12 | - | Goal II: Living the Dream | $13,200 | - | 10 | - | $1,320 | $13,200 | 1 | Buena Vista International | true | false |
| 13 | 9 | Perfect Stranger | $11,957 | -35.6% | 18 | -8 | $664 | $583,080 | 8 | Sony Pictures Releasing | false | false |
| 14 | - | Samoan Wedding | $9,748 | - | 15 | - | $649 | $9,478 | 1 | Ster-Kinekor Pictures | true | false |
| 15 | 13 | The Reef | $8,969 | -29.9% | 17 | -3 | $527 | $282,938 | 8 | NuMetro Distribution | false | false |
| 16 | - | Reno 911!: Miami | $8,258 | - | 10 | - | $825 | $8,258 | 1 | United International Pictures | true | false |
| 17 | 15 | Freedom Writers | $8,144 | -4.3% | 4 | -19 | $2,036 | $88,237 | 4 | United International Pictures | false | false |
| 18 | 16 | Perfume: The Story of a Murderer | $5,271 | -27.3% | 5 | - | $1,054 | $28,199 | 3 | NuMetro Distribution | false | false |
| 19 | 10 | The Number 23 | $4,585 | -71.6% | 8 | -14 | $573 | $114,389 | 4 | NuMetro Distribution | false | false |
| 20 | 17 | Mr. Bean's Holiday | $3,517 | -49.4% | 10 | -3 | $351 | $2,255,425 | 11 | United International Pictures | false | false |
| 21 | 19 | Shooter | $3,420 | -35.7% | 10 | -5 | $342 | $388,503 | 7 | United International Pictures | false | false |
| 22 | 20 | Hot Fuzz | $707 | -27.4% | 3 | +1 | $235 | $264,817 | 8 | United International Pictures | false | false |
