| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: At World's End | $350,994 | -34.5% | 100 | +57 | $3,509 | $2,252,696 | 3 | Buena Vista International | false | false |
| 2 | 2 | Papelucho y el marciano | $85,877 | -27.2% | 33 | - | $2,602 | $734,091 | 4 | Bazuca Films | false | false |
| 3 | 3 | Spider-Man 3 | $55,186 | -37.5% | 58 | -13 | $951 | $2,878,214 | 6 | Sony Pictures Releasing | false | false |
| 4 | 4 | Zodiac | $34,937 | -11.6% | 12 | - | $2,911 | $95,952 | 2 | Warner Bros. | false | false |
| 5 | 5 | Scoop | $16,400 | -25.6% | 7 | - | $2,342 | $166,333 | 5 | CDI Films | false | false |
| 6 | 6 | The Queen | $7,595 | -30.7% | 8 | - | $949 | $245,913 | 7 | Bazuca Films | false | false |
| 7 | 12 | The Good Shepherd | $6,587 | +27.2% | 6 | - | $1,097 | $107,343 | 7 | United International Pictures | false | false |
| 8 | 10 | A Prairie Home Companion | $5,128 | -18.1% | 5 | -1 | $1,025 | $14,260 | 2 | N/A | false | false |
| 9 | 9 | Hoodwinked! | $4,498 | -28.2% | 8 | +1 | $562 | $255,896 | 7 | Transeuropa | false | false |
| 10 | 7 | The Reaping | $3,827 | -56.4% | 5 | -5 | $765 | $469,168 | 10 | Warner Bros. | false | false |
| 11 | 11 | Sunshine | $3,461 | -33.4% | 5 | -2 | $692 | $112,090 | 7 | 20th Century Fox International | false | false |
| 12 | 24 | Happily N'Ever After | $2,107 | +2,072.2% | 4 | +3 | $526 | $144,606 | 8 | Bazuca Films | false | false |
| 13 | 13 | Hard Candy | $1,962 | -45.7% | 2 | -1 | $981 | $30,108 | 4 | Bazuca Films | false | false |
| 14 | 14 | Apocalypto | $1,758 | -43.3% | 2 | -1 | $879 | $364,065 | 14 | 20th Century Fox International | false | false |
| 15 | 15 | Shooter | $1,240 | -41.9% | 3 | - | $413 | $105,151 | 9 | United International Pictures | false | false |
| 16 | 18 | Meet the Robinsons | $943 | +6.7% | 3 | -1 | $314 | $519,115 | 10 | Buena Vista International | false | false |
| 17 | 19 | TMNT | $777 | -8.6% | 4 | - | $194 | $234,670 | 10 | Bazuca Films | false | false |
| 18 | 16 | Epic Movie | $242 | -86% | 2 | -3 | $121 | $166,404 | 8 | 20th Century Fox International | false | false |
| 19 | 22 | Ghost Rider | $195 | +32.7% | 1 | - | $195 | $268,740 | 10 | Sony Pictures Releasing | false | false |
| 20 | 8 | Pulse | $181 | -97.6% | 1 | -7 | $181 | $173,249 | 8 | Bazuca Films | false | false |
| 21 | 21 | Pathfinder | $162 | -20.6% | 3 | - | $54 | $122,882 | 9 | 20th Century Fox International | false | false |
| 22 | 23 | Music and Lyrics | $118 | +8.3% | 1 | - | $118 | $209,768 | 13 | Warner Bros. | false | false |
