| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: At World's End | $536,012 | -43.7% | 43 | +5 | $12,465 | $1,688,504 | 2 | Buena Vista International | false | false |
| 2 | 3 | Papelucho y el marciano | $118,040 | +25.1% | 33 | +1 | $3,576 | $596,141 | 3 | Bazuca Films | false | false |
| 3 | 2 | Spider-Man 3 | $88,263 | -33% | 71 | -12 | $1,243 | $2,789,683 | 5 | Sony Pictures Releasing | false | false |
| 4 | - | Zodiac | $39,518 | - | 12 | - | $3,293 | $39,518 | 1 | Warner Bros. | true | false |
| 5 | 4 | Scoop | $22,044 | +10.3% | 7 | +1 | $3,149 | $143,726 | 4 | CDI Films | false | false |
| 6 | 5 | The Queen | $10,961 | +15.8% | 8 | +2 | $1,370 | $235,422 | 6 | Bazuca Films | false | false |
| 7 | 6 | The Reaping | $8,782 | -5% | 10 | - | $878 | $458,851 | 9 | Warner Bros. | false | false |
| 8 | 10 | Pulse | $7,648 | +189.4% | 8 | +1 | $956 | $173,068 | 7 | Bazuca Films | false | false |
| 9 | 8 | Hoodwinked! | $6,265 | +27.7% | 7 | -6 | $895 | $249,440 | 6 | Transeuropa | false | false |
| 10 | - | A Prairie Home Companion | $6,265 | - | 6 | - | $1,044 | $6,265 | 1 | N/A | true | false |
| 11 | 12 | Sunshine | $5,195 | +175% | 7 | +2 | $742 | $106,894 | 6 | 20th Century Fox International | false | false |
| 12 | 7 | The Good Shepherd | $5,178 | -31% | 6 | - | $863 | $99,634 | 6 | United International Pictures | false | false |
| 13 | 9 | Hard Candy | $3,614 | -20.1% | 3 | - | $1,204 | $26,692 | 3 | Bazuca Films | false | false |
| 14 | 15 | Apocalypto | $3,101 | +204.3% | 3 | +1 | $1,033 | $361,565 | 13 | 20th Century Fox International | false | false |
| 15 | - | Shooter | $2,134 | - | 3 | - | $711 | $102,840 | 8 | United International Pictures | false | false |
| 16 | 13 | Epic Movie | $1,726 | -1% | 5 | -2 | $345 | $165,480 | 7 | 20th Century Fox International | false | false |
| 17 | 11 | Mr. Bean's Holiday | $1,398 | -46.6% | 3 | -6 | $466 | $309,265 | 9 | United International Pictures | false | false |
| 18 | 14 | Meet the Robinsons | $884 | -46.4% | 4 | -2 | $221 | $516,798 | 9 | Buena Vista International | false | false |
| 19 | 20 | TMNT | $850 | +28.2% | 4 | -1 | $212 | $233,658 | 9 | Bazuca Films | false | false |
| 20 | 16 | Man About Town | $495 | -47.1% | 3 | - | $165 | $19,326 | 4 | Andes Films | false | false |
| 21 | 17 | Pathfinder | $204 | -76.8% | 3 | -1 | $68 | $122,429 | 8 | 20th Century Fox International | false | false |
| 22 | 22 | Ghost Rider | $147 | +14% | 1 | - | $147 | $268,452 | 9 | Sony Pictures Releasing | false | false |
| 23 | 21 | Music and Lyrics | $109 | -72.6% | 1 | -1 | $109 | $209,591 | 12 | Warner Bros. | false | false |
| 24 | 18 | Happily N'Ever After | $97 | -88.6% | 1 | -3 | $97 | $142,459 | 7 | Bazuca Films | false | false |
