| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Spider-Man 3 | $518,537 | -54.8% | 90 | - | $5,761 | $1,909,383 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Scoop | $30,869 | - | 7 | - | $4,409 | $30,869 | 1 | CDI Films | true | false |
| 3 | 2 | Hoodwinked! | $24,626 | -38.2% | 20 | - | $1,231 | $187,705 | 3 | Transeuropa | false | false |
| 4 | 3 | The Queen | $22,987 | -38% | 9 | - | $2,554 | $161,105 | 3 | Bazuca Films | false | false |
| 5 | 4 | 300 | $16,944 | -43.1% | 28 | -5 | $605 | $1,467,406 | 7 | Warner Bros. | false | false |
| 6 | 5 | Meet the Robinsons | $16,743 | -36.1% | 33 | -2 | $507 | $496,087 | 6 | Buena Vista International | false | false |
| 7 | 6 | The Reaping | $13,984 | -29.8% | 17 | -2 | $822 | $379,734 | 6 | Warner Bros. | false | false |
| 8 | 10 | Happily N'Ever After | $11,501 | -14.9% | 13 | -2 | $884 | $126,068 | 4 | Bazuca Films | false | false |
| 9 | 7 | Mr. Bean's Holiday | $11,357 | -29.8% | 16 | -4 | $709 | $280,911 | 6 | United International Pictures | false | false |
| 10 | 8 | Pulse | $10,959 | -29.3% | 13 | -1 | $843 | $121,719 | 4 | Bazuca Films | false | false |
| 11 | 9 | The Good Shepherd | $10,437 | -27.4% | 5 | -1 | $2,087 | $62,776 | 3 | United International Pictures | false | false |
| 12 | 11 | Epic Movie | $9,535 | -21% | 13 | -1 | $733 | $130,936 | 4 | 20th Century Fox International | false | false |
| 13 | 12 | Sunshine | $6,764 | -38.3% | 12 | -2 | $563 | $74,091 | 3 | 20th Century Fox International | false | false |
| 14 | - | Man About Town | $5,881 | - | 7 | - | $840 | $5,881 | 1 | Andes Films | true | false |
| 15 | 16 | Pathfinder | $4,010 | -7.1% | 9 | +1 | $445 | $111,890 | 5 | 20th Century Fox International | false | false |
| 16 | 14 | Apocalypto | $3,857 | -19.4% | 3 | -3 | $1,285 | $344,477 | 10 | 20th Century Fox International | false | false |
| 17 | 13 | TMNT | $2,585 | -58.8% | 13 | -4 | $198 | $225,901 | 6 | Bazuca Films | false | false |
| 18 | 17 | Music and Lyrics | $2,515 | -40.7% | 2 | - | $1,257 | $204,012 | 9 | Warner Bros. | false | false |
| 19 | 18 | Shooter | $1,879 | -21.6% | 6 | +1 | $313 | $95,227 | 5 | United International Pictures | false | false |
| 20 | 15 | Ghost Rider | $1,279 | -70.6% | 7 | -5 | $182 | $266,592 | 6 | Sony Pictures Releasing | false | false |
| 21 | 19 | The Pursuit of Happyness | $610 | -45.4% | 2 | -1 | $305 | $237,182 | 14 | Sony Pictures Releasing | false | false |
| 22 | 23 | The Last King of Scotland | $221 | -56.7% | 1 | - | $221 | $106,993 | 13 | 20th Century Fox International | false | false |
| 23 | 21 | The Road to Guantanamo | $177 | -75.7% | 1 | - | $177 | $7,614 | 3 | Transeuropa | false | false |
| 24 | 22 | Curse of the Golden Flower | $146 | -73.4% | 1 | -2 | $146 | $116,610 | 8 | Sony Pictures Releasing | false | false |
