| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Spider-Man 3 | $1,147,009 | - | 90 | - | $12,744 | $1,147,009 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Hoodwinked! | $39,840 | - | 20 | - | $1,992 | $156,398 | 2 | Transeuropa | false | false |
| 3 | - | The Queen | $37,085 | - | 9 | - | $4,120 | $125,110 | 2 | Bazuca Films | false | false |
| 4 | - | 300 | $29,769 | - | 33 | - | $902 | $1,434,064 | 6 | Warner Bros. | false | false |
| 5 | - | Meet the Robinsons | $26,188 | - | 35 | - | $748 | $470,503 | 5 | Buena Vista International | false | false |
| 6 | - | The Reaping | $19,912 | - | 19 | - | $1,048 | $356,665 | 5 | Warner Bros. | false | false |
| 7 | - | Mr. Bean's Holiday | $16,183 | - | 20 | - | $809 | $264,846 | 5 | United International Pictures | false | false |
| 8 | - | Pulse | $15,507 | - | 14 | - | $1,107 | $105,742 | 3 | Bazuca Films | false | false |
| 9 | - | The Good Shepherd | $14,367 | - | 6 | - | $2,394 | $47,972 | 2 | United International Pictures | false | false |
| 10 | - | Happily N'Ever After | $13,508 | - | 15 | - | $900 | $111,985 | 3 | Bazuca Films | false | false |
| 11 | - | Epic Movie | $12,065 | - | 14 | - | $861 | $117,668 | 3 | 20th Century Fox International | false | false |
| 12 | - | Sunshine | $10,962 | - | 14 | - | $783 | $62,420 | 2 | 20th Century Fox International | false | false |
| 13 | - | TMNT | $6,275 | - | 17 | - | $369 | $222,314 | 5 | Bazuca Films | false | false |
| 14 | - | Apocalypto | $4,788 | - | 6 | - | $798 | $339,039 | 9 | 20th Century Fox International | false | false |
| 15 | - | Ghost Rider | $4,344 | - | 12 | - | $362 | $264,296 | 5 | Sony Pictures Releasing | false | false |
| 16 | - | Pathfinder | $4,318 | - | 8 | - | $539 | $104,867 | 4 | 20th Century Fox International | false | false |
| 17 | - | Music and Lyrics | $4,242 | - | 2 | - | $2,121 | $200,741 | 8 | Warner Bros. | false | false |
| 18 | - | Shooter | $2,397 | - | 5 | - | $479 | $92,446 | 4 | United International Pictures | false | false |
| 19 | - | The Pursuit of Happyness | $1,118 | - | 3 | - | $372 | $236,246 | 13 | Sony Pictures Releasing | false | false |
| 20 | - | Pan's Labyrinth | $866 | - | 1 | - | $866 | $245,640 | 11 | Warner Bros. | false | false |
| 21 | - | The Road to Guantanamo | $727 | - | 1 | - | $727 | $7,020 | 2 | Transeuropa | false | false |
| 22 | - | Curse of the Golden Flower | $549 | - | 3 | - | $183 | $116,234 | 7 | Sony Pictures Releasing | false | false |
| 23 | - | The Last King of Scotland | $510 | - | 1 | - | $510 | $106,637 | 12 | 20th Century Fox International | false | false |
| 24 | - | Infection 2006 Re-release | $55 | - | 1 | - | $55 | $42,955 | 10 | Andes Films | false | false |
