| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Ho voglia di te | $8,214,552 | - | 575 | - | $14,286 | $8,214,552 | 1 | Warner Bros. | true | false |
| 2 | - | Saw III | $1,866,151 | - | 305 | - | $6,118 | $1,866,151 | 1 | 20th Century Fox International | true | false |
| 3 | 1 | Borat | $1,718,308 | -43.3% | 393 | -14 | $4,372 | $5,841,107 | 2 | 20th Century Fox International | false | false |
| 4 | 2 | Saturn in Opposition | $1,205,472 | -29.4% | 329 | -70 | $3,664 | $7,895,309 | 3 | Medusa Distribuzione | false | false |
| 5 | 4 | Music and Lyrics | $654,744 | -32% | 210 | -116 | $3,117 | $4,171,324 | 3 | Warner Bros. | false | false |
| 6 | 3 | Notte prima degli esami - Oggi | $569,725 | -51.5% | 209 | -182 | $2,725 | $15,443,078 | 4 | 01 Distribution | false | false |
| 7 | 7 | One Out of Two | $377,758 | -7.1% | 154 | -22 | $2,452 | $1,009,211 | 2 | 01 Distribution | false | false |
| 8 | 6 | Alpha Dog | $302,290 | -36.1% | 124 | -66 | $2,437 | $2,139,020 | 3 | Moviemax | false | false |
| 9 | 5 | Night at the Museum | $276,310 | -41.9% | 126 | -69 | $2,192 | $14,802,356 | 6 | 20th Century Fox International | false | false |
| 10 | 10 | Notes on a Scandal | $251,837 | +3.1% | 93 | - | $2,707 | $1,212,051 | 3 | 20th Century Fox International | false | false |
| 11 | 13 | Barnyard | $205,205 | +5.7% | 148 | -2 | $1,386 | $907,973 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 12 | The Good German | $200,236 | -6.5% | 80 | +1 | $2,502 | $504,645 | 2 | Warner Bros. | false | false |
| 13 | - | In Memory of Me | $184,865 | - | 88 | - | $2,100 | $186,334 | 1 | Medusa Distribuzione | true | false |
| 14 | 9 | The Holiday | $93,737 | -61.9% | 51 | -82 | $1,837 | $5,735,530 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | 14 | Arthur and the Invisibles | $93,019 | -17.9% | 45 | -97 | $2,067 | $644,284 | 5 | 01 Distribution | false | false |
| 16 | 16 | The Last King of Scotland | $83,856 | -6.6% | 87 | +40 | $963 | $2,346,359 | 4 | 20th Century Fox International | false | false |
| 17 | 15 | The Painted Veil | $81,812 | -19.7% | 42 | -17 | $1,947 | $458,146 | 3 | Eagle Pictures | false | false |
| 18 | 17 | Letters from Iwo Jima | $77,684 | -12.8% | 34 | -6 | $2,284 | $762,379 | 4 | Warner Bros. | false | false |
| 19 | 11 | The Departed | $74,465 | -65.4% | 36 | -87 | $2,068 | $12,237,244 | 20 | Medusa Distribuzione | false | false |
| 20 | 8 | Hannibal Rising | $64,483 | -75.6% | 44 | -87 | $1,465 | $7,566,213 | 5 | Filmauro | false | false |
