| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Notte prima degli esami - Oggi | $3,100,136 | -48.3% | 589 | -15 | $5,263 | $12,680,774 | 2 | 01 Distribution | false | false |
| 2 | - | Saturn in Opposition | $3,035,165 | - | 379 | - | $8,008 | $3,035,165 | 1 | Medusa Distribuzione | true | false |
| 3 | - | Music and Lyrics | $1,669,084 | - | 325 | - | $5,135 | $1,669,084 | 1 | Warner Bros. | true | false |
| 4 | 2 | Night at the Museum | $1,112,968 | -35.1% | 263 | -101 | $4,231 | $13,750,648 | 4 | 20th Century Fox International | false | false |
| 5 | - | Alpha Dog | $855,992 | - | 185 | - | $4,626 | $855,992 | 1 | Moviemax | true | false |
| 6 | 3 | Hannibal Rising | $750,604 | -51.8% | 228 | -130 | $3,292 | $6,897,364 | 3 | Filmauro | false | false |
| 7 | 4 | The Holiday | $631,938 | -50% | 224 | -95 | $2,821 | $5,104,847 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | - | Notes on a Scandal | $422,429 | - | 94 | - | $4,493 | $422,429 | 1 | 20th Century Fox International | true | false |
| 9 | - | Barnyard | $403,041 | - | 150 | - | $2,686 | $403,041 | 1 | Universal Pictures International (UPI) | true | false |
| 10 | 6 | Arthur and the Invisibles | $276,204 | -45.6% | 176 | -144 | $1,569 | $2,090,535 | 3 | 01 Distribution | false | false |
| 11 | 11 | Letters from Iwo Jima | $184,507 | -13.3% | 55 | +8 | $3,354 | $491,800 | 2 | Warner Bros. | false | false |
| 12 | 9 | Blood Diamond | $152,366 | -59.1% | 71 | -64 | $2,146 | $5,468,627 | 5 | Warner Bros. | false | false |
| 13 | - | The Painted Veil | $151,068 | - | 65 | - | $2,324 | $151,068 | 1 | Eagle Pictures | true | false |
| 14 | 7 | A Dinner for Them to Meet | $131,551 | -72.6% | 74 | -131 | $1,777 | $3,821,047 | 4 | Medusa Distribuzione | false | false |
| 15 | 8 | The Pursuit of Happyness | $130,144 | -65.5% | 64 | -74 | $2,033 | $20,129,248 | 7 | Medusa Distribuzione | false | false |
| 16 | 5 | Manual of Love 2 | $130,012 | -75.8% | 73 | -113 | $1,780 | $24,888,990 | 6 | Filmauro | false | false |
| 17 | 13 | The Last King of Scotland | $105,214 | -39.2% | 48 | -1 | $2,191 | $357,240 | 2 | 20th Century Fox International | false | false |
| 18 | 10 | Mi fido di te | $85,153 | -64% | 53 | -57 | $1,606 | $830,828 | 3 | Medusa Distribuzione | false | false |
| 19 | 15 | The Page Turner | $48,607 | -44.7% | 26 | -3 | $1,869 | $285,469 | 3 | Mikado Film | false | false |
| 20 | 17 | Inland Empire | $46,008 | -39.2% | 23 | -3 | $2,000 | $332,125 | 3 | BIM Distribuzione | false | false |
