| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Ghost Rider | $3,121,567 | - | 415 | - | $7,521 | $3,121,567 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Blood Diamond | $1,411,588 | -39.3% | 348 | -3 | $4,056 | $4,412,514 | 2 | Warner Bros. | false | false |
| 3 | 2 | Night at the Museum | $1,123,042 | -45.7% | 427 | -41 | $2,630 | $14,235,953 | 4 | 20th Century Fox International | false | false |
| 4 | 3 | The Pursuit of Happyness | $1,050,084 | -33.2% | 290 | - | $3,620 | $5,998,411 | 3 | Sony Pictures Releasing | false | false |
| 5 | 4 | John Tucker Must Die | $588,627 | -34.6% | 250 | +1 | $2,354 | $1,631,244 | 2 | 20th Century Fox International | false | false |
| 6 | 5 | Babel | $446,678 | -23.6% | 212 | - | $2,106 | $12,148,123 | 8 | United International Pictures | false | false |
| 7 | - | Manual of Love 2 | $408,260 | - | 165 | - | $2,474 | $408,260 | 1 | DeAPlaneta | true | false |
| 8 | - | Letters from Iwo Jima | $368,967 | - | 68 | - | $5,425 | $368,967 | 1 | Warner Bros. | true | false |
| 9 | - | The Lives of Others | $282,881 | - | 77 | - | $3,673 | $282,881 | 1 | Alta Films | true | false |
| 10 | 10 | Little Children | $221,328 | -29.7% | 110 | - | $2,012 | $643,293 | 2 | TriPictures | false | false |
| 11 | 8 | Apocalypto | $212,580 | -44.4% | 215 | -52 | $988 | $5,638,051 | 5 | - | false | false |
| 12 | 9 | Miss Potter | $210,037 | -39.5% | 185 | +1 | $1,135 | $675,205 | 2 | - | false | false |
| 13 | 6 | Pulse | $158,930 | -64.9% | 202 | -49 | $786 | $1,705,829 | 3 | DeAPlaneta | false | false |
| 14 | 12 | Pan's Labyrinth | $154,177 | -17.5% | 92 | -3 | $1,675 | $10,574,026 | 19 | Warner Bros. | false | false |
| 15 | 7 | Días de cine | $147,500 | -62.5% | 250 | +2 | $590 | $636,029 | 2 | Buena Vista International | false | false |
| 16 | 11 | Black Book | $138,987 | -36.7% | 74 | -7 | $1,878 | $877,152 | 3 | Manga Entertainment | false | false |
| 17 | - | The Backwoods | $123,881 | - | 120 | - | $1,032 | $123,913 | 1 | Filmax | true | false |
| 18 | 19 | Little Miss Sunshine | $74,213 | -18.2% | 38 | -1 | $1,952 | $3,489,091 | 18 | 20th Century Fox International | false | false |
| 19 | 14 | Dreamgirls | $74,067 | -51.4% | 114 | -43 | $649 | $1,514,259 | 4 | Universal Pictures International (UPI) | false | false |
