| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Ghost Rider | $1,945,956 | - | 208 | - | $9,355 | $1,945,956 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Music and Lyrics | $1,781,536 | - | 275 | - | $6,478 | $2,385,492 | 1 | Warner Bros. | true | false |
| 3 | - | Notes on a Scandal | $796,480 | - | 101 | - | $7,885 | $1,115,860 | 1 | 20th Century Fox International | true | false |
| 4 | - | The Good Shepherd | $766,235 | - | 197 | - | $3,889 | $766,235 | 1 | Paramount Pictures International | true | false |
| 5 | 2 | Miss Potter | $382,590 | -34.4% | 227 | -13 | $1,685 | $4,252,043 | 4 | Icon Film Distribution | false | false |
| 6 | 1 | Hannibal Rising | $261,655 | -57.6% | 131 | - | $1,997 | $1,125,013 | 2 | Roadshow Films | false | false |
| 7 | 3 | Deja Vu | $243,160 | -52.1% | 163 | -87 | $1,491 | $6,815,738 | 5 | Buena Vista International | false | false |
| 8 | 5 | The Pursuit of Happyness | $228,053 | -52.4% | 176 | -41 | $1,295 | $10,337,262 | 6 | Sony Pictures Releasing | false | false |
| 9 | 4 | Epic Movie | $218,496 | -54.5% | 177 | -26 | $1,234 | $4,909,380 | 4 | 20th Century Fox International | false | false |
| 10 | 9 | Babel | $192,869 | -27.5% | 91 | - | $2,119 | $4,766,675 | 8 | United International Pictures | false | false |
| 11 | 6 | Smokin' Aces | $185,576 | -60.3% | 140 | - | $1,325 | $874,545 | 2 | Paramount Pictures International | false | false |
| 12 | 12 | The Queen | $180,429 | -22.7% | 129 | - | $1,398 | $6,327,086 | 8 | Icon Film Distribution | false | false |
| 13 | 7 | Stranger Than Fiction | $179,098 | -54% | 122 | - | $1,468 | $1,581,373 | 3 | Roadshow Films | false | false |
| 14 | 10 | Blood Diamond | $135,784 | -45.8% | 102 | -31 | $1,331 | $5,942,701 | 7 | Warner Bros. | false | false |
| 15 | 13 | The Last King of Scotland | $124,222 | -30% | 57 | -1 | $2,179 | $803,489 | 3 | 20th Century Fox International | false | false |
| 16 | 8 | Dreamgirls | $96,279 | -65.3% | 101 | -58 | $953 | $3,556,913 | 5 | Paramount Pictures International | false | false |
| 17 | 14 | Casino Royale | $91,341 | -48.2% | 63 | -48 | $1,449 | $24,993,221 | 11 | Sony Pictures Releasing | false | false |
| 18 | 18 | Pan's Labyrinth | $77,284 | -32.5% | 27 | -4 | $2,862 | $1,126,260 | 6 | Hopscotch Films | false | false |
| 19 | 17 | Little Children | $77,039 | -45.5% | 41 | - | $1,879 | $324,913 | 2 | Roadshow Films | false | false |
| 20 | 11 | Employee of the Month | $74,790 | -69.7% | 129 | -14 | $579 | $420,359 | 2 | Hoyts Distribution | false | false |
| 21 | - | Eklavya: The Royal Guard | $66,228 | - | 12 | - | $5,519 | $66,228 | 1 | Eros Worldwide | true | false |
| 22 | - | Flyboys | $41,059 | - | 55 | - | $746 | $41,059 | 1 | Hoyts Distribution | true | false |
| 23 | - | Venus | $16,295 | - | 20 | - | $814 | $16,295 | - | Icon Film Distribution | - | false |
