| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Blood Diamond | $349,251 | -26.5% | 79 | - | $4,420 | $1,690,252 | 3 | Warner Bros. | false | false |
| 2 | 2 | The Pursuit of Happyness | $230,821 | -13.7% | 33 | - | $6,994 | $607,847 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | The Prestige | $194,283 | - | 30 | - | $6,476 | $195,189 | 1 | Warner Bros. | true | false |
| 4 | 3 | Smokin' Aces | $144,155 | -28.1% | 40 | +1 | $3,603 | $449,394 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Casino Royale | $118,163 | -25% | 90 | -6 | $1,312 | $10,221,952 | 12 | Sony Pictures Releasing | false | false |
| 6 | 6 | Arthur and the Invisibles | $105,596 | +2.8% | 86 | - | $1,227 | $259,291 | 2 | Independent Films | false | false |
| 7 | 7 | Happy Feet | $100,273 | +6.3% | 120 | -16 | $835 | $6,988,700 | 10 | Warner Bros. | false | false |
| 8 | 5 | The Holiday | $72,964 | -38.8% | 80 | -9 | $912 | $4,611,035 | 9 | United International Pictures | false | false |
| 9 | 10 | Babel | $69,654 | -3.6% | 36 | +2 | $1,934 | $1,808,363 | 15 | Independent Films | false | false |
| 10 | - | The Last King of Scotland | $60,957 | - | 15 | - | $4,063 | $65,268 | 1 | 20th Century Fox International | true | false |
| 11 | - | Miss Potter | $56,060 | - | 51 | - | $1,099 | $87,978 | 1 | RCV Film Distribution | true | false |
| 12 | 8 | Apocalypto | $46,330 | -47.6% | 62 | -17 | $747 | $1,121,164 | 5 | A-Film Distribution | false | false |
| 13 | 9 | Deja Vu | $44,715 | -38.8% | 52 | -9 | $859 | $2,563,987 | 9 | Buena Vista International | false | false |
| 14 | 18 | Happy Family | $44,389 | +7.8% | 52 | -4 | $853 | $1,170,367 | 9 | RCV Film Distribution | false | false |
| 15 | 16 | Crusade in Jeans | $43,108 | -9% | 93 | -5 | $463 | $3,906,766 | 13 | Benelux Film Distributors | false | false |
| 16 | 11 | Little Children | $40,560 | -30.8% | 17 | - | $2,385 | $214,793 | 3 | A-Film Distribution | false | false |
| 17 | 19 | Charlotte's Web | $40,213 | +17% | 89 | -1 | $451 | $1,589,375 | 8 | United International Pictures | false | false |
| 18 | 12 | Perfume: The Story of a Murderer | $39,681 | -32% | 39 | -11 | $1,017 | $1,680,176 | 10 | RCV Film Distribution | false | false |
| 19 | 17 | The Queen | $39,295 | -10.9% | 24 | +1 | $1,637 | $962,875 | 11 | A-Film Distribution | false | false |
| 20 | 15 | Black Book | $36,754 | -25.7% | 46 | -3 | $799 | $9,588,375 | 22 | A-Film Distribution | false | false |
