| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Hannibal Rising | $617,708 | - | 131 | - | $4,715 | $617,708 | 1 | Roadshow Films | true | false |
| 2 | 2 | Miss Potter | $583,558 | -27% | 240 | - | $2,431 | $3,518,841 | 3 | Icon Film Distribution | false | false |
| 3 | 3 | Deja Vu | $507,372 | -34.5% | 250 | -21 | $2,029 | $6,273,432 | 4 | Buena Vista International | false | false |
| 4 | 1 | Epic Movie | $480,135 | -44.5% | 203 | -3 | $2,365 | $4,516,163 | 3 | 20th Century Fox International | false | false |
| 5 | 4 | The Pursuit of Happyness | $478,735 | -34.8% | 217 | -3 | $2,206 | $9,765,149 | 5 | Sony Pictures Releasing | false | false |
| 6 | - | Smokin' Aces | $467,855 | - | 140 | - | $3,341 | $467,855 | 1 | Paramount Pictures International | true | false |
| 7 | 5 | Stranger Than Fiction | $389,186 | -35% | 122 | -2 | $3,190 | $1,235,855 | 2 | Roadshow Films | false | false |
| 8 | 6 | Dreamgirls | $277,455 | -39.7% | 159 | -10 | $1,745 | $3,300,672 | 4 | Paramount Pictures International | false | false |
| 9 | 12 | Babel | $265,984 | +2.3% | 91 | +21 | $2,922 | $4,394,982 | 7 | United International Pictures | false | false |
| 10 | 10 | Blood Diamond | $250,418 | -24% | 133 | -11 | $1,882 | $5,626,999 | 6 | Warner Bros. | false | false |
| 11 | - | Employee of the Month | $247,045 | - | 143 | - | $1,727 | $247,045 | 1 | Hoyts Distribution | true | false |
| 12 | 7 | The Queen | $233,478 | -33.1% | 129 | - | $1,809 | $5,905,182 | 7 | Icon Film Distribution | false | false |
| 13 | 13 | The Last King of Scotland | $177,465 | -27.6% | 58 | - | $3,059 | $581,747 | 2 | 20th Century Fox International | false | false |
| 14 | 8 | Casino Royale | $176,331 | -49.5% | 111 | -48 | $1,588 | $24,506,728 | 10 | Sony Pictures Releasing | false | false |
| 15 | 9 | Night at the Museum | $173,426 | -48% | 216 | -29 | $802 | $18,361,918 | 7 | 20th Century Fox International | false | false |
| 16 | 11 | Happy Feet | $164,897 | -49% | 271 | +1 | $608 | $24,190,417 | 7 | Roadshow Films | false | false |
| 17 | - | Little Children | $141,443 | - | 41 | - | $3,449 | $172,748 | 1 | Roadshow Films | true | false |
| 18 | 14 | Pan's Labyrinth | $114,421 | -27.7% | 31 | +2 | $3,691 | $986,558 | 5 | Hopscotch Films | false | false |
| 19 | - | Tenacious D in the Pick of Destiny | $110,032 | - | 41 | - | $2,683 | $110,032 | 1 | Roadshow Films | true | false |
| 20 | 15 | Perfume: The Story of a Murderer | $80,624 | -40.7% | 46 | - | $1,752 | $319,464 | 2 | Hoyts Distribution | false | false |
