| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Pursuit of Happyness | $174,407 | -33.9% | 51 | - | $3,419 | $573,099 | 2 | Sony Pictures Releasing | false | false |
| 2 | 2 | Epic Movie | $132,105 | -45.3% | 40 | - | $3,302 | $505,239 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | Blood Diamond | $98,218 | -30.3% | 43 | - | $2,284 | $583,748 | 3 | Warner Bros. | false | false |
| 4 | - | Rocky Balboa | $95,333 | - | 40 | - | $2,383 | $95,333 | 1 | 20th Century Fox International | true | false |
| 5 | 4 | Happy Feet | $84,244 | -20.9% | 72 | -3 | $1,170 | $2,830,297 | 6 | Roadshow Films | false | false |
| 6 | 5 | Open Season | $79,886 | -21.3% | 65 | -2 | $1,229 | $851,442 | 4 | Sony Pictures Releasing | false | false |
| 7 | 6 | Casino Royale | $55,106 | -41.8% | 59 | -11 | $934 | $3,954,640 | 9 | Sony Pictures Releasing | false | false |
| 8 | - | Stranger Than Fiction | $54,897 | - | 20 | - | $2,744 | $54,897 | 1 | Roadshow Films | true | false |
| 9 | 7 | The Queen | $53,145 | -35.8% | 52 | -6 | $1,022 | $1,301,963 | 7 | Icon Film Distribution | false | false |
| 10 | 8 | Night at the Museum | $50,181 | -32.1% | 54 | -9 | $929 | $1,765,275 | 6 | 20th Century Fox International | false | false |
| 11 | 9 | Dreamgirls | $43,808 | -40.3% | 34 | -1 | $1,288 | $364,079 | 3 | Paramount Pictures International | false | false |
| 12 | 13 | The History Boys | $43,730 | +19% | 9 | -1 | $4,858 | $101,344 | 2 | 20th Century Fox International | false | false |
| 13 | 10 | Apocalypto | $41,207 | -31.3% | 34 | +2 | $1,211 | $563,980 | 4 | Hoyts Distribution | false | false |
| 14 | 11 | Babel | $31,317 | -21.9% | 14 | -1 | $2,236 | $335,910 | 5 | United International Pictures | false | false |
| 15 | - | A Prairie Home Companion | $26,403 | - | 24 | - | $1,100 | $27,024 | 1 | - | true | false |
| 16 | 14 | Borat | $25,451 | -14% | 37 | +3 | $687 | $2,306,989 | 11 | 20th Century Fox International | false | false |
| 17 | 15 | The Valet | $22,976 | +9.4% | 17 | - | $1,351 | $409,658 | 7 | Rialto Distribution | false | false |
| 18 | 12 | Arthur and the Invisibles | $22,334 | -39.3% | 29 | -5 | $770 | $170,307 | 3 | Roadshow Films | false | false |
| 19 | 17 | Charlotte's Web | $13,829 | -27.6% | 37 | -9 | $373 | $655,825 | 7 | United International Pictures | false | false |
| 20 | 18 | Volver | $13,360 | -26.9% | 15 | +2 | $890 | $74,239 | 3 | Dendy Films | false | false |
