| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum | $4,725,640 | - | 471 | - | $10,033 | $4,725,640 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Manual of Love 2 | $2,691,400 | -49.7% | 494 | -94 | $5,448 | $21,537,251 | 3 | Filmauro | false | false |
| 3 | 2 | The Pursuit of Happyness | $1,567,611 | -40.6% | 339 | -81 | $4,624 | $17,712,596 | 4 | Medusa Distribuzione | false | false |
| 4 | - | A Dinner for Them to Meet | $1,364,020 | - | 262 | - | $5,206 | $1,364,020 | 1 | Medusa Distribuzione | true | false |
| 5 | 4 | Blood Diamond | $1,192,271 | -23.4% | 266 | +2 | $4,482 | $3,435,020 | 2 | Warner Bros. | false | false |
| 6 | 3 | Step Up | $1,177,953 | -24.9% | 238 | +2 | $4,949 | $3,447,026 | 2 | Medusa Distribuzione | false | false |
| 7 | - | Miss Potter | $231,853 | - | 146 | - | $1,588 | $231,853 | 1 | Eagle Pictures | true | false |
| 8 | 7 | Bobby | $221,109 | -40.4% | 76 | -65 | $2,909 | $1,425,308 | 3 | 01 Distribution | false | false |
| 9 | 5 | Rocky Balboa | $167,988 | -75.1% | 91 | -162 | $1,846 | $8,287,514 | 4 | 20th Century Fox International | false | false |
| 10 | - | Stranger Than Fiction | $155,226 | - | 96 | - | $1,616 | $155,226 | 1 | Sony Pictures Releasing | true | false |
| 11 | 6 | Casino Royale | $151,996 | -67.7% | 67 | -99 | $2,268 | $10,146,663 | 5 | Sony Pictures Releasing | false | false |
| 12 | - | Black Book | $135,389 | - | 69 | - | $1,962 | $139,114 | 1 | DNC Entertainment | true | false |
| 13 | 8 | Dreamgirls | $107,249 | -70.1% | 98 | -74 | $1,094 | $611,862 | 2 | Universal Pictures International (UPI) | false | false |
| 14 | 12 | The Science of Sleep | $79,670 | -39.3% | 35 | -13 | $2,276 | $572,561 | 3 | Mikado Film | false | false |
| 15 | 13 | The Boss of It All | $66,538 | -34% | 27 | -9 | $2,464 | $1,156,661 | 5 | Lucky Red | false | false |
| 16 | 11 | Flushed Away | $55,879 | -63.5% | 73 | -52 | $765 | $8,377,731 | 7 | United International Pictures | false | false |
| 17 | 9 | Apocalypto | $46,600 | -84% | 27 | -101 | $1,725 | $8,495,465 | 5 | Eagle Pictures | false | false |
| 18 | 14 | Little Red Flowers | $36,790 | -37.2% | 16 | -6 | $2,299 | $254,600 | 4 | Istituto Luce | false | false |
| 19 | 17 | A Good Year | $32,256 | -23.1% | 17 | -13 | $1,897 | $704,675 | 8 | Medusa Distribuzione | false | false |
| 20 | 18 | After the Wedding | $28,490 | -31.8% | 15 | -7 | $1,899 | $614,345 | 7 | Teodora Film | false | false |
