| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Casino Royale | $260,799 | -24.1% | 109 | -13 | $2,392 | $9,651,276 | 9 | Sony Pictures Releasing | false | false |
| 2 | 1 | Apocalypto | $243,013 | -34.9% | 81 | - | $3,000 | $706,475 | 2 | A-Film Distribution | false | false |
| 3 | - | Rocky Balboa | $235,457 | - | 58 | - | $4,059 | $241,484 | 1 | 20th Century Fox International | true | false |
| 4 | 4 | The Holiday | $216,797 | -26.5% | 95 | -1 | $2,282 | $4,153,060 | 6 | United International Pictures | false | false |
| 5 | 5 | Happy Feet | $189,825 | -20.5% | 158 | -11 | $1,201 | $6,588,183 | 7 | Warner Bros. | false | false |
| 6 | 3 | Saw III | $155,861 | -50% | 62 | +1 | $2,513 | $1,446,745 | 3 | Independent Films | false | false |
| 7 | 6 | Deja Vu | $149,154 | -24.4% | 67 | -3 | $2,226 | $2,280,057 | 6 | Buena Vista International | false | false |
| 8 | 8 | Crusade in Jeans | $88,490 | -13% | 120 | +23 | $737 | $3,676,369 | 10 | Benelux Film Distributors | false | false |
| 9 | 7 | Perfume: The Story of a Murderer | $84,516 | -27.9% | 51 | +1 | $1,657 | $1,434,749 | 7 | RCV Film Distribution | false | false |
| 10 | 10 | Happy Family | $69,960 | -9.8% | 56 | -2 | $1,249 | $997,155 | 6 | RCV Film Distribution | false | false |
| 11 | 16 | Babel | $67,176 | +41.3% | 24 | +3 | $2,799 | $1,508,227 | 12 | Independent Films | false | false |
| 12 | 12 | Charlotte's Web | $62,653 | <0.1% | 94 | - | $666 | $1,467,456 | 5 | United International Pictures | false | false |
| 13 | - | Bobby | $57,074 | - | 18 | - | $3,170 | $77,295 | 1 | Benelux Film Distributors | true | false |
| 14 | 11 | Black Book | $56,926 | -11.6% | 51 | -2 | $1,116 | $9,339,620 | 19 | A-Film Distribution | false | false |
| 15 | 15 | Flushed Away | $53,824 | +6.5% | 100 | -9 | $538 | $1,555,073 | 8 | United International Pictures | false | false |
| 16 | 14 | The Queen | $52,725 | +4.3% | 21 | -2 | $2,510 | $747,376 | 8 | A-Film Distribution | false | false |
| 17 | 13 | The Illusionist | $50,004 | -17.9% | 15 | - | $3,333 | $258,303 | 3 | Independent Films | false | false |
| 18 | 9 | Eragon | $44,462 | -53.7% | 86 | -11 | $517 | $2,072,987 | 6 | 20th Century Fox International | false | false |
| 19 | 18 | Plop in de stad | $34,171 | -7.2% | 96 | -5 | $355 | $830,801 | 6 | Independent Films | false | false |
| 20 | - | Nacho Libre | $32,924 | - | 12 | - | $2,743 | $53,346 | 1 | Universal Pictures International (UPI) | true | false |
