| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Happy Feet | $37,945,000 | $37,038,046 | -$906,954 | -2.4% | 3,804 | $100,126,000 | $99,256,766 | 2 | Warner Bros. | - |
| 2 | 2 | - | Casino Royale | $31,000,000 | $30,785,874 | -$214,126 | -0.7% | 3,443 | $94,223,000 | $94,053,658 | 2 | Sony Pictures Releasing | - |
| 3 | 3 | - | Deja Vu | $20,836,000 | $20,574,802 | -$261,198 | -1.3% | 3,108 | $29,029,000 | $28,649,398 | 1 | Walt Disney Studios Motion Pictures | - |
| 4 | 4 | - | Deck the Halls | $12,000,000 | $12,001,256 | +$1,256 | <0.1% | 3,205 | $16,882,000 | $16,916,923 | 1 | Twentieth Century Fox | - |
| 5 | 5 | - | Borat | $10,400,000 | $10,304,802 | -$95,198 | -0.9% | 2,552 | $109,280,000 | $109,136,807 | 4 | Twentieth Century Fox | - |
| 6 | 6 | - | The Santa Clause 3: The Escape Clause | $10,016,000 | $9,929,029 | -$86,971 | -0.9% | 3,043 | $67,199,000 | $67,073,095 | 4 | Walt Disney Studios Motion Pictures | - |
| 7 | 8 | +1 | Stranger Than Fiction | $6,000,000 | $5,726,536 | -$273,464 | -4.6% | 2,258 | $32,761,000 | $32,504,604 | 3 | Sony Pictures Releasing | - |
| 8 | 7 | -1 | Flushed Away | $5,841,000 | $5,756,455 | -$84,545 | -1.4% | 2,621 | $57,366,000 | $57,266,350 | 4 | DreamWorks | - |
| 9 | 9 | - | Bobby | $4,909,000 | $4,857,736 | -$51,264 | -1% | 1,667 | $6,157,000 | $6,100,358 | 2 | - | - |
| 10 | 10 | - | The Fountain | $3,725,000 | $3,768,702 | +$43,702 | +1.2% | 1,472 | $5,400,000 | $5,456,908 | 1 | Warner Bros. | - |
| 11 | 11 | - | Tenacious D in the Pick of Destiny | $3,110,000 | - | - | - | 1,919 | $5,185,000 | - | 1 | New Line Cinema | - |
| 12 | 12 | - | The Queen | $2,559,000 | - | - | - | 653 | $20,965,000 | - | 9 | Miramax | - |
| 13 | 14 | +1 | For Your Consideration | $1,985,000 | $1,924,071 | -$60,929 | -3.1% | 623 | $3,101,000 | $3,017,715 | 2 | Warner Independent Pictures (WIP) | - |
| 14 | 13 | -1 | Babel | $1,943,000 | $1,968,883 | +$25,883 | +1.3% | 902 | $15,169,000 | $15,194,482 | 5 | Paramount Vantage | - |
| 15 | 15 | - | The Departed | $1,805,000 | $1,709,135 | -$95,865 | -5.3% | 910 | $116,800,000 | $116,748,722 | 8 | Warner Bros. | - |
| 16 | 19 | +3 | The Prestige | $902,000 | $861,024 | -$40,976 | -4.5% | 565 | $51,150,000 | $51,099,913 | 6 | Walt Disney Studios Motion Pictures | - |
| 17 | 20 | +3 | Volver | $519,000 | $512,127 | -$6,873 | -1.3% | 30 | $1,339,000 | $1,331,883 | 4 | Sony Pictures Classics | - |
| 18 | 21 | +3 | The Return | $319,000 | - | - | - | 421 | $7,619,000 | - | 3 | Rogue Pictures | - |
| 19 | 23 | +4 | Flags of Our Fathers | $311,000 | $309,265 | -$1,735 | -0.6% | 362 | $33,307,000 | $33,306,143 | 6 | DreamWorks | - |
| 20 | 29 | +9 | Fast Food Nation | $196,000 | $200,278 | +$4,278 | +2.2% | 252 | $780,000 | $780,641 | 2 | - | - |
| 21 | 36 | +15 | The Wedding Weekend | $129,000 | $127,328 | -$1,672 | -1.3% | 68 | - | $637,546 | 5 | The Weinstein Company | - |
| 22 | 41 | +19 | One Night with the King | $114,000 | $100,015 | -$13,985 | -12.3% | 83 | $13,344,000 | $13,329,757 | 7 | 8x Entertainment | - |
| 23 | 40 | +17 | The History Boys | $101,000 | $100,803 | -$197 | -0.2% | 7 | $142,000 | $142,379 | 1 | - | - |
| 24 | 47 | +23 | Jackass Number Two | $68,000 | $67,601 | -$399 | -0.6% | 152 | $72,756,000 | $72,755,517 | 10 | Paramount Pictures | - |
